Postdoctoral researcher at Wageningen University | Plant pathogens | (epi)Genomics | Evolution | he/him
Joined January 2011
- Tweets 2,018
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25 Feb 2024
Im so happy to share this part of my PhD thesis just right now in @NatureComms. Check it out! Implications of the 3D chromatin organization for genome evolution in a fungal plant pathogen Special thanks to @MFSeidl and @Team_Thomma nature.com/articles/s41467-0…
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This is very awesome. Open source AlphaFold. From @ChanZuckerberg
nature.com/articles/d41586-0…
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Thrilled to see this finally out!!
Our new work suggests #Starships helped #Colletotrichum acquire the genes needed to infect lupin.
A glimpse into how fungal pathogens emerge through horizontal transfer and genome reshaping.
biorxiv.org/content/10.64898…
#Fungi #Genomics
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🚨 EffectorGeneP is finally here! Stop missing small, single-exon or orphan genes from your favourite pathogen genome. Current tools only annotate 15%-78% of effector genes, EffectorGeneP finds 95% - including the large AvrSr26 family in stem rust. biorxiv.org/content/10.64898…
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Apr 30
🎉 📰 Very happy to share the journal publication of our manuscript "Plant-associated fungi co-opt ancient antimicrobials for host manipulation"! #ScienceAdvancesResearch @ScienceMagazine
@Team_Thomma
science.org/doi/10.1126/scia…
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Nature research paper: Ancient co-option of LTR retrotransposons as yeast centromeres
go.nature.com/404vd9X
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Feb 13
Vorholt Lab re-created endosymbiosis in the lab: injected bacteria into a fungus and evolved a heritable partnership.
Evolution, fast-forwarded.
doi.org/10.1038/s41586-024-0…
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Feb 6
Check out our recent preprint on the structure of a non C-JID TNL resistosome from flax.
We are very proud of the persistence of Natsumi who got this long running project over the line and a congratulations to all involved.
Check it out... doi.org/10.64898/2026.02.03.…
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Feb 3
Genome contamination may lead to an overestimation of horizontal gene transfer inferences | Nature Communications nature.com/articles/s41467-0…
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Jan 21
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
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Big congrats to PhD @Ken_M_Mugambi for pulling together this amazing piece of work 🫡
This study details the genome biology of the largest #AMF genome (G. margarita) and its intricate links with its🦠 endosymbiont and 🌱hosts 😀
biorxiv.org/content/10.64898…
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Join us in Norwich this July for the TSL Summer Conference in Plant-Microbe Interactions! ☀️🌱🧬
Discuss the latest approaches & discoveries in plant health with international keynote and local speakers.
APPLY by 30 March '26 ⬇️ Click link for more info
tsl.ac.uk/tsl-summer-conf-20…
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New online! Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription dlvr.it/TQKgsH
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Jan 8
Can we design mutations that predictably bias proteins towards desired conformational states?
Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
science.org/doi/10.1126/scie…
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Epigenetics Update - Stress controls heterochromatin inheritance via histone H3 ubiquitylation go.nature.com/4pwTxvp
Shiv I. S. Grewal reporting in Nature
#Epigenetics #Heterochromatin #Ubiquitylation
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Gain deeper insights into gene regulation; epigenometech.com
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Salicylic acid contributes to plant defense against a necrotroph: evidence from a transgenic NahG-expressing strain in Botrytis cinerea. biorxiv.org/content/10.64898… #biorxiv_plants
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How does AlphaFold select protein conformations? Its transformer model (Evoformer) associates them with sparse sequence patterns. We developed a method to identify these patterns readily🧵
biorxiv.org/content/10.64898…
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New online! A genomic and epigenomic view of human centromeres bit.ly/4jvn3A8
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Jan 6
Evolutionary transcriptomics unveils rapid changes of gene expression patterns in flowering plants
cell.com/cell/fulltext/S0092…
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The one that abstained: Psilocybe fuscofulva genome suggests two recent origins of the psilocybin gene cluster in Psilocybe biorxiv.org/content/10.64898… #biorxiv_evobio
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26 Dec 2025
Well done, Akie! Identification of a peptide hormone-receptor module bypassing the ABA signaling to close stomata upon drought. A big breakthrough🍃😊
-Local peptide signalling induces stomatal closure under drought stress @NatureComms
nature.com/articles/s41467-0…
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