Opioids cause dependence, tolerance, and ultimately because of those, an awful lot of overdose death. Journavx, the first non-opioid painkiller, may allow us to avoid an awful lot of this worksinprogress.news/p/the-f…

The approval of Journavx (suzetrigine) marks a major step in non-opioid pain management. Could this shift pain treatment strategies? Explore its potential impact: bit.ly/433EbqH #PainRelief #FDAApproval

The best thing might be to simply go to the other worlds ourselves (or send our robot proxies) to do gardening directly - spreading life, but also keeping it from turning too painful.

Our view is that a temporary moratorium on directed panspermia is a good idea. It is early days in space, time is cheap, we need to figure out more about the balance between suffering risk and value of life, or how to make life that tends to evolve to high wellbeing.

Thank you for the interview, @slatestarcodex! This is an excellent primer into many aspects of our exploratory work and the emerging suffering abolitionist ecosystem. astralcodexten.com/p/profile…

I hope Jo’s entire genome can be put in the public domain.

Latigo Biotherapeutics launched Wednesday with $135 million and plans to compete with Vertex Pharmaceuticals. trib.al/7HeHU8D

Weirdly, my aggressively-pro-this thing tweet which I expected to generate tons of pushback instead largely led to agreement 🤷‍♂️

Hot take, but ~this should probably be like the second biggest EA cause area, after X-risk. The fact that things like this are approximately totally neglected by EA makes me think worse of the non-X-risk parts of EA.

Far Out goes far out near @nearcyan. Thank you for the exposure! We started an FAQ section to answer common questions: faroutinitiative.com/FAQ

Congratulations to The Far Out Initiative on receiving its first @slatestarcodex grant! The initiative is heavily inspired by Jo Cameron, a woman born with a genetic condition resulting in immunity to physical and psychological pain (fear, anxiety, etc.). Unlike other forms of congenital pain insensitivity, her condition does not carry the same negative side effects. This discovery revealed a possible path to abolishing suffering — the path the initiative is pursuing from the following angles: The Anandaimonia Project: Research into solving human suffering by targeting the genetic basis of pain, both physical and mental. This would involve genetic and pharmacological interventions. The Ananda Lines: Creating lines of gene-edited livestock animals who possess the same resistance to physical and psychological pain. This aims to transform factory farming practices and reduce the vast suffering endured by these animals. The Far Out Initiative's goals are heavily aligned with QRI's mission statement. We highly encourage everyone to check them out! @cease_suffering

possibly the best use of $50,000 I've seen in my life

We seem grossly oversupplied on suffering, overall. I mean a little suffering now and then for good cause, that’s one of the spices of life, but this is absurd. Who ordered all this suffering? What were they even thinking? This is like, suffering for 10 trillion beings.

I think it's important to emphasize just how lucky we are to have been born into a timeline with someone with Jo Cameron's condition and how insane we would be not to take this opportunity and run with it. Reflexive and unreflective incredulity is the biggest problem that Suffering Abolitionism faces. How can something that has been plaguing life for billions of years be ended now with a simple genetic intervention? Well, we got lucky. Incredibly lucky. We could've spent centuries exploring the genome for a solution to suffering. Instead, we happened to discover someone with a naturally occurring genetic condition that eliminates physical and psychological suffering, which can be transferred to others using existing gene editing techniques. We would be mad not to seize this opportunity and run with it. The Far Out Initiative is taking the lead on doing the foundational research required to create anti-suffering therapies for humans and human-exploited animals. Find out more at: faroutinitiative.com - Michael Spark, founder of the initiative Guys, please check them out! And donate if you can. They're one of the absolutely most promising ideas/and groups to radically reduce suffering worldwide.

In honor of #IASP50, IASP proudly presents a special edition of #PAIN. Delve into this compendium of articles that reflect on the advances made by IASP members within pain research. Access for free: bit.ly/40aliyD

Ignorant question: how efficient is CRISPR editing in vivo? How far are we from being able to edit every cell in a complex organism? Is that a distant pipe dream?

Kevin Esvelt: “I want to live in a world where we’ve obviated material scarcity, where no one has to suffer unless they want to, where no one has to wither away and cease to exist involuntarily.” 80000hours.org/podcast/episo…

Why isn’t there an annual international meeting to solve wild animal suffering?