Personal account, mostly retweets and stuff. Occasional radiology gems

Joined September 2008
108 Photos and videos
Brad 🧠💀☢️ retweeted
🚨BREAKING: OpenAI published a paper proving that ChatGPT will always make things up. Not sometimes. Not until the next update. Always. They proved it with math. Even with perfect training data and unlimited computing power, AI models will still confidently tell you things that are completely false. This isn't a bug they're working on. It's baked into how these systems work at a fundamental level. And their own numbers are brutal. OpenAI's o1 reasoning model hallucinates 16% of the time. Their newer o3 model? 33%. Their newest o4-mini? 48%. Nearly half of what their most recent model tells you could be fabricated. The "smarter" models are actually getting worse at telling the truth. Here's why it can't be fixed. Language models work by predicting the next word based on probability. When they hit something uncertain, they don't pause. They don't flag it. They guess. And they guess with complete confidence, because that's exactly what they were trained to do. The researchers looked at the 10 biggest AI benchmarks used to measure how good these models are. 9 out of 10 give the same score for saying "I don't know" as for giving a completely wrong answer: zero points. The entire testing system literally punishes honesty and rewards guessing. So the AI learned the optimal strategy: always guess. Never admit uncertainty. Sound confident even when you're making it up. OpenAI's proposed fix? Have ChatGPT say "I don't know" when it's unsure. Their own math shows this would mean roughly 30% of your questions get no answer. Imagine asking ChatGPT something three times out of ten and getting "I'm not confident enough to respond." Users would leave overnight. So the fix exists, but it would kill the product. This isn't just OpenAI's problem. DeepMind and Tsinghua University independently reached the same conclusion. Three of the world's top AI labs, working separately, all agree: this is permanent. Every time ChatGPT gives you an answer, ask yourself: is this real, or is it just a confident guess?
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Brad 🧠💀☢️ retweeted
The math on this project should mass-humble every AI lab on the planet. 1 cubic millimeter. One-millionth of a human brain. Harvard and Google spent 10 years mapping it. The imaging alone took 326 days. They sliced the tissue into 5,000 wafers each 30 nanometers thick, ran them through a $6 million electron microscope, then needed Google’s ML models to stitch the 3D reconstruction because no human team could process the output. The result: 57,000 cells, 150 million synapses, 230 millimeters of blood vessels, compressed into 1.4 petabytes of raw data. For context, 1.4 petabytes is roughly 1.4 million gigabytes. From a speck smaller than a grain of rice. Now scale that. The full human brain is one million times larger. Mapping the whole thing at this resolution would produce approximately 1.4 zettabytes of data. That’s roughly equal to all the data generated on Earth in a single year. The storage alone would cost an estimated $50 billion and require a 140-acre data center, which would make it the largest on the planet. And they found things textbooks don’t contain. One neuron had over 5,000 connection points. Some axons had coiled themselves into tight whorls for completely unknown reasons. Pairs of cell clusters grew in mirror images of each other. Jeff Lichtman, the Harvard lead, said there’s “a chasm between what we already know and what we need to know.” This is why the next step isn’t a human brain. It’s a mouse hippocampus, 10 cubic millimeters, over the next five years. Because even a mouse brain is 1,000x larger than what they just mapped, and the full mouse connectome is the proof of concept before anyone attempts the human one. We’re building AI systems that loosely mimic neural networks while still unable to fully read the wiring diagram of a single cubic millimeter of the thing we’re trying to imitate. The original is 1.4 petabytes per millionth of its volume. Every AI model on Earth fits in a fraction of that. The brain runs on 20 watts and fits in your skull. The data center required to merely describe one-millionth of it would span 140 acres.
🚨: Scientists mapped 1 mm³ of a human brain ─ less than a grain of rice ─ and a microscopic cosmos appeared.
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One of the coolest things I’ve seen on X
In medical school, we are taught a golden rule: "When you hear hoofbeats, think horses, not zebras." It is a reminder to look for the common explanation before the exotic one. But after decades in cardiology, I’ve learned that if a patient is still suffering after the "horses" have been ruled out, a doctor must have the courage—and the curiosity—to go hunting for the zebra. Sarah was a thirty-four-year-old marathon runner and a devoted mother who came to me after six months of being told she was "fine." She had been bounced from one specialist to another, each one pointing to her normal EKG and standard blood tests as proof that her crushing fatigue and racing heart were simply the result of "new mom stress." By the time she reached my office, she didn't just look tired; she looked invisible, as if the medical system had stopped seeing the woman and only saw the data. Instead of re-reading the normal test results that had already failed her, I asked Sarah to walk me through her life. We talked about her training and her family, eventually landing on a backpacking trip she took to the Mendoza province of rural Argentina. She described staying in a charming, rustic cottage made of sun-dried mud bricks. She mentioned waking up one morning with a strangely swollen, purple eyelid that she assumed was a simple spider bite. As she spoke, a memory surfaced from a biography I had read years ago about Charles Darwin. Most people know Darwin for his theories on evolution, but medical historians have long puzzled over the mysterious, debilitating illness that plagued him for decades after he returned from his voyage on the HMS Beagle. Darwin had written in his journals about being bitten by the "great black bug of the Pampas" while sleeping in mud-walled huts in South America. He spent the rest of his life suffering from heart palpitations and exhaustion that the Victorian doctors of his time could never explain. I realized then that Sarah wasn't suffering from stress; she was likely hosting the same "silent killer" that may have haunted Darwin: Chagas Disease. The "Kissing Bug" lives in the cracks of those mud-brick walls. It bites its victims—often near the eyes or mouth—while they sleep, passing a parasite called Trypanosoma cruzi into the blood. The danger of Chagas is that the initial symptoms disappear quickly, but the parasite can hide in the body for years, slowly weaving itself into the muscle and electrical "wiring" of the heart. To confirm this, I moved beyond the standard tests. I ordered a specialized "Strain Rate" ultrasound, which doesn't just look at whether the heart is pumping, but at how the individual muscle fibers are stretching. We saw that while her heart looked strong to the naked eye, the fibers were "stuttering," a sign of early parasite-induced scarring. A specific blood test for the parasite's antibodies confirmed the diagnosis. Treatment required a difficult, sixty-day course of anti-parasitic medication to stop the infection, paired with a protective heart regimen to keep her electrical system stable while the inflammation settled. Because we caught it before her heart was physically damaged or enlarged, the recovery was a success. Months later, Sarah returned to my office, her vibrant energy restored. She brought me a leather-bound copy of The Voyage of the Beagle with a note tucked inside. She wrote that while other doctors had looked at her charts, I had looked at her. This case remains a vital reminder for my memoir: in a world of high-tech scans and AI, the most sophisticated diagnostic tool we possess is still the human story. When we truly listen, we don't just find the disease—we find the patient. Good morning.
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Brad 🧠💀☢️ retweeted
BREAKING: STATEMENT BY PRESIDENT OBAMA AND MRS. OBAMA The killing of Alex Pretti is a heartbreaking tragedy. It should also be a wake-up call to every American, regardless of party, that many of our core values as a nation are increasingly under assault. Federal law enforcement and immigration agents have a tough job. But Americans expect them to carry out their duties in a lawful, accountable way, and to work with, rather than against, state and local officials to ensure public safety. That’s not what we’re seeing in Minnesota. In fact, we’re seeing the opposite. For weeks now, people across the country have been rightly outraged by the spectacle of masked ICE recruits and other federal agents acting with impunity and engaging in tactics that seem designed to intimidate, harass, provoke and endanger the residents of a major American city. These unprecedented tactics—which even the former top lawyer of the Department of Homeland Security in the first Trump administration has characterized as embarrassing, lawless and cruel—have now resulted in the fatal shootings of two U.S. citizens. And yet rather than trying to impose some semblance of discipline and accountability over the agents they’ve deployed, the President and current administration officials seem eager to escalate the situation, while offering public explanations for the shootings of Mr. Pretti and Renee Good that aren’t informed by any serious investigation—and that appear to be directly contradicted by video evidence. This has to stop. I would hope that after this most recent tragedy, administration officials will reconsider their approach, and start finding ways to work constructively with Governor Walz and Mayor Frey as well as state and local police to avert more chaos and achieve legitimate law enforcement goals. In the meantime, every American should support and draw inspiration from the wave of peaceful protests in Minneapolis and other parts of the country. They are a timely reminder that ultimately it’s up to each of us as citizens to speak out against injustice, protect our basic freedoms, and hold our government accountable.
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Brad 🧠💀☢️ retweeted
10 Sep 2025
I disagreed with Charlie Kirk on just about everything. But, we shared an opposition to "gender identity" and the abolition of sex. He once had me on his show to discuss it. He was polite, outgoing, and funny. During the interview, I said something about the "TQIA." He exclaimed, "I don't know what any of that means!" I said, "Don't worry, nobody does." He and his entire audience laughed. I am not a Republican, and I am certainly not MAGA. But I am grieving his death in part because he was a human being, in part because he leaves behind a wife and two children, and in part because of what this says about American society. I will not take any part in any political violence, and I will stand with anyone, wherever they stand on the political spectrum, who will denounce it. I hope America can recover from this. #RIP EDIT: I will block anyone who comes on here to glorify violence.
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Brad 🧠💀☢️ retweeted
10 Sep 2025
The assassination of Charlie Kirk is truly disturbing. I'm in shock. There should be no place for political violence in this country. This is not what America is about. We are better than this. Rest in Peace Charlie 🙏
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Brad 🧠💀☢️ retweeted
We don’t yet know what motivated the person who shot and killed Charlie Kirk, but this kind of despicable violence has no place in our democracy. Michelle and I will be praying for Charlie’s family tonight, especially his wife Erika and their two young children.
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Brad 🧠💀☢️ retweeted
29 Jul 2025
Being overly political is a sign of mental illness and an unstable life. You are emotionally invested into things you have practically 0 impact on, which constantly impacts your mood. I couldn’t imagine following this stuff daily, subjecting myself to whatever nonsense the current thing is. If you have responsibilities and things to do in your social life, there’s no reason you should be religiously following every little thing which happens, you simply don’t have time, and would not want to subject yourself to unneeded negativity energy.
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RT @sapinker: Trump's assault on foreign students at Harvard is truly depraved. It harms thousands of the smartest people in the country fo…
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Brad 🧠💀☢️ retweeted
17 Apr 2025
Difficult to overstate how remarkable the Wilkinson opinion is. For seasoned readers of these opinions, the tone and substance are unmistakably unique and severe. This was not a normal opinion for Wilkinson. He knew and clearly hoped the entire country would read this—and I think it will easily be a legacy-defining opinion for his entire career. It reads as if he knew it would be when he wrote it. He delivered. I hope the country heeds his warning.
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Brad 🧠💀☢️ retweeted
The federal government doesn’t ‘give’ money to Harvard. The $2.2 billion in frozen payments isn’t for Harvard sophomores’ tuition or library books. The US government is buying services from Harvard: scientific & medical research & development. These aren’t ‘woke donations.’ They are contracts. Proposed, reviewed, awarded, with metrics and deadlines and standards of performance. Harvard is a government contractor in that sense — lab by lab, scientist by scientist — just the way any other company is a contractor. That’s true of Columbia’s $400 million in ‘frozen’ contracts — and all the rest. R1 research universities do crucial research the federal government can’t do itself, but that we as a nation have decided we need done. Mission driven. Pioneering. Essential. They can’t be done — as Sean Hannity just suggested — at community colleges & vocational schools. That’s not what the $2.2 billion is being spent on. …You could Google it. Of course.
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Brad 🧠💀☢️ retweeted
The country is 100% behind the president on fixing a global system of tariffs that has disadvantaged the country. But, business is a confidence game and confidence depends on trust. President @realDonaldTrump has elevated the tariff issue to the most important geopolitical issue in the world, and he has gotten everyone’s attention. So far, so good. And yes, other nations have taken advantage of the U.S. by protecting their home industries at the expense of millions of our jobs and economic growth in our country. But, by placing massive and disproportionate tariffs on our friends and our enemies alike and thereby launching a global economic war against the whole world at once, we are in the process of destroying confidence in our country as a trading partner, as a place to do business, and as a market to invest capital. The president has an opportunity to call a 90-day time out, negotiate and resolve unfair asymmetric tariff deals, and induce trillions of dollars of new investment in our country. If, on the other hand, on April 9th we launch economic nuclear war on every country in the world, business investment will grind to a halt, consumers will close their wallets and pocket books, and we will severely damage our reputation with the rest of the world that will take years and potentially decades to rehabilitate. What CEO and what board of directors will be comfortable making large, long-term, economic commitments in our country in the middle of an economic nuclear war? I don’t know of one who will do so. When markets crash, new investment stops, consumers stop spending money, and businesses have no choice but to curtail investment and fire workers. And it is not just the big companies that will suffer. Small and medium size businesses and entrepreneurs will experience much greater pain. Almost no business can pass through an overnight massive increase in costs to their customers. And that’s true even if they have no debt, and, unfortunately, there is a massive amount of leverage in the system. Business is a confidence game. The president is losing the confidence of business leaders around the globe. The consequences for our country and the millions of our citizens who have supported the president — in particular low-income consumers who are already under a huge amount of economic stress — are going to be severely negative. This is not what we voted for. The President has an opportunity on Monday to call a time out and have the time to execute on fixing an unfair tariff system. Alternatively, we are heading for a self-induced, economic nuclear winter, and we should start hunkering down. May cooler heads prevail.
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Without a blue check, might as well be talking to myself. But I’ll post this anyway, because Applebaum gets it. It’s not about liberal vs conservative or Democrat vs Republican-the real battle playing out right now is democracy vs autocracy/kleptocracy: apple.news/A1qo_OMqPS06XhDfn…
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Brad 🧠💀☢️ retweeted
A sobering message from a history teacher: I’ve spent years teaching American and international government — from strong democracies like the UK to authoritarian regimes like russia and China. But lately, the most alarming lesson comes from home. 1/n
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Brad 🧠💀☢️ retweeted
Giving infectious disease research a break, as promised by the MAHA agenda. Let's break down what exactly this Executive Order is *really* saying. Fortunately, I speak fluent anti-vax grifterese & can translate. whitehouse.gov/presidential-…
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Brad 🧠💀☢️ retweeted
Social media is the opiate of the masses
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Brad 🧠💀☢️ retweeted
I don’t want to connect my coffee machine to the wifi network. I don’t want to share the file with OneDrive. I don’t want to download an app to check my car’s fluid levels. I don’t want to scan a QR code to view the restaurant menu. I don’t want to let Google know my location before showing me the search results. I don’t want to include a Teams link on the calendar invite. I don’t want to pay 50 different monthly subscription fees for all my software. I don’t want to upgrade to TurboTax platinum plus audit protection. I don’t want to install the Webex plugin to join the meeting. I don’t want to share my car’s braking data with the actuaries at State Farm. I don’t want to text with your AI chatbot. I don’t want to download the Instagram app to look at your picture. I don’t want to type in my email address to view the content on your company’s website. I don’t want text messages with promo codes. I don’t want to leave your company a five-star Google review in exchange for the chance to win a $20 Starbucks gift card. I don’t want to join your exclusive community in the metaverse. I don’t want AI to help me write my comments on LinkedIn. I don’t even want to be on LinkedIn in the first place. I just want to pay for a product one time (and only one time), know that it’s going to work flawlessly, press 0 to speak to an operator if I need help, and otherwise be left alone and treated with some small measure of human dignity, if that’s not too much to ask anymore.
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Brad 🧠💀☢️ retweeted
6 Feb 2025
If the people doing this, from @elonmusk on down, are honest about their intentions, they should have zero problem publishing EVERYTHING they are doing on a daily basis i absolutely want to see @Doge reduce wasteful spending. But i want the process to be transparent.. I don't want to have to guess which media reports are accurate or not. If this is the result of a detailed plan. I want to see the plan. If this is legal. I want to see the law that supports it. If there are questions about whether it is, I want to see the opposition. This isn't a shock and awe attack on foreign soil. This is a shock and awe attack on American Systems and Economics. That doesn't mean it shouldn't happen. But if it should, then it should be 100 pct transparent. If they hide anything, they are doing it wrong. If they hide anything, that means the goals is not the interest of the American People. We were promised transparency. We should see everything
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Brad 🧠💀☢️ retweeted
“The dumbest trade war in history” The WSJ Editorial Board slams Trump’s trade war with Camada and Mexico: “Mr. Trump sometimes sounds as if the U.S. shouldn’t import anything at all, that America can be a perfectly closed economy making everything at home. This is called autarky, and it isn’t the world we live in, or one that we should want to live in, as Mr. Trump may soon find out… None of this is supposed to happen under the U.S.-Mexico-Canada trade agreement that Mr. Trump negotiated and signed in his first term. The U.S. willingness to ignore its treaty obligations, even with friends, won’t make other countries eager to do deals. Maybe Mr. Trump will claim victory and pull back if he wins some token concessions. But if a North American trade war persists, it will qualify as one of the dumbest in history."
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Brad 🧠💀☢️ retweeted
21 Jan 2025
Rev. Mariann Edgar Budde to Trump: "I ask you to have mercy upon the people in our country who are scared now. There are gay, lesbian, and transgender people in Democratic, Republican, and independent families, some who fear for their lives ... and the vast majority of immigrants are not criminals"
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