Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen…  and how you can join me on this journey 🧵(1/7)

To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics. I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com  🧵(6/7)

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.

RT @RecursionPharma: Join us for Recursion’s (L)earnings Call today, 8/8 at 6:30am MT / 8:30am ET. Submit questions at t.co/DpwLr1…

🚨🦇🫒🚨 Alerta de espécie nova de morcego frugívoro - um dos menores do mundo (5g) que comem frutas. Vou contar aqui um pouco de como foi a descoberta e descrição dessa espécie nova descrita por dois pesquisadores brasileiros e dois mexicanos. doi.org/10.1093/jmammal/gyae… 1/9

Exscientia will start a new #AI drug discovery collaboration with @MerckHealthcare, combining our AI-driven precision design capabilities with Merck’s oncology & I&I expertise, clinical capabilities. ($20M u/f, $674M total to $EXAI); investors.exscientia.ai/pres…

More than the global pandemic or getting a permanent job or Musk buying Twitter, this is the most compelling evidence that I fell into a coma sometime in 2019 and none of this is real.

Looking to benchmark a model-guided protein design method? Running into the limitations of existing datasets? Excited to present SLIP (Synthetic Landscape Inference for Proteins), a suite of tuned fitness landscapes. Preprint: biorxiv.org/content/10.1101/…

Pretty wild that there have been at least 4-5 antibody-specific structure prediction tools this year, all based on #deeplearning 1. DeepAb/IgFold (@jeffruffolo) 2. ABLooper/ImmuneBuilder (@brennanaba) 3. Equifold (@jaehyeon_lee_ml) 4. t-AbFold What does this mean? 🧵(1/6)

Introducing Grove - a Discord server for synthetic biology developers

Você sabia que existe um termo técnico para "cutucar o nariz", que é "rinotilexia"? Um estudo recente mostrou que pelo menos 12 primatas cutucam o nariz rotineiramente. Um deles, o lêmure ai-ai faz praticamente um teste de covid enfiando o dedo 3 até a faringe 👀 Segue o🧵

We report that simply clustering a MSA lets #AlphaFold predict multiple states of fold-switching proteins. We used this to screen for alt states in proteins without known fold-switching, and describe one such predicted novel state for the DsbE enzyme. 1/n tinyurl.com/4ewfxf7x

We are excited to present PropertyDAG: Multi-objective Bayesian optimization of partially ordered, mixed-variable properties for biological sequence design! 🧵 arxiv.org/abs/2210.04096

Does anyone know how $AMRS, $CDXS, @Genomatica, LS9 went about engineering 🦠’s in 2008-2010? Were they designing pathways by drawing them out on paper, building by hand & measuring by hand? Little software/automation? No assembly of thousands of pathways from standard parts?

Ticketing systems, for all their faults and failures in being leaky abstractions, are unsung wonders of the world in that they allow bureaucracies to not immediately forget about things when passed between hands.

(not mine)

"Open the pod bay doors, HAL." "I'm sorry, Dave. I'm afraid I can't -" "Open the pod bay doors, best pod bay door openings, Olympic level door opening performance, best open bay doors of 1999, Yahoo featured site, daily pod bay -" "Dave -" "Let's reason step by step."