We make people (and technology) better at Mount Sinai. Opinions are my own.

Joined June 2014
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With some new followers on board, I wanted to take the time to re-introduce myself to the #LongCovid community (and everyone else). I’m David Putrino: Director of Rehab Innovation at @MountSinaiNYC, Associate Prof at @MountSinaiRehab for @IcahnMountSinai 1/
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Concerning story about #COVID, #LongCOVID and cancer risk. Dovetails with the work we have been been doing with @drmfreire's team showing that persistent SARS-CoV-2 antigen found in the GI tract of pwLC is pro-inflammatory and oncogenic: biorxiv.org/content/10.64898… Stay safe 🙏
“When lab mice with dormant breast cancer cells were infected with either influenza or SARS-CoV-2, the animals were significantly more likely to develop aggressive lung tumors.” “something similar appeared to be going on in the human population.”
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Putrino Lab retweeted
🚨 Major news for ME/CFS research: WE&ME has launched a new research call worth over €1 million in total funding, supporting around 7 biomedical ME/CFS projects. What makes this especially notable, alongside the substantial funding volume from a foundation in a small country, is the degree of patient involvement. Members of the Science for ME (@s4me_info) community were heavily involved in shaping the call and will also play a major role in the review and jury process, helping guide funding decisions themselves. At the same time, the process includes internationally respected ME/CFS experts whose judgment and expertise I trust deeply. I may be wrong, but this could be one of the most patient-driven biomedical ME/CFS research funding calls of this scale to date. A huge thank you to everyone involved: the patients, patient advocates, researchers, WE&ME, the WWTF team around Benjamin Missbach, and all partners who helped make this possible. Most importantly, thank you to everyone who fundraised for or donated to WE&ME. This is where your money is going: directly into new biomedical ME/CFS research. Please share as much as possible! 🙏
📢 New funding opportunity in ME/CFS research. The WE&ME FOUNDATION has launched its first independent Call for Proposals to support research on the biological mechanisms of ME/CFS. Applications will be evaluated by an independent international expert jury. More information: weandmecfs.org/weme-projects…
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A thread today about Immunoglobulin G (IgG) antibodies to various pathogens and why they seem to be elevated a lot in people with #LongCOVID, #MECFS, chronic #lyme/tick- and vector-borne illnesses and other complex chronic illnesses. First, let's start basic: what is IgG? 1/
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more susceptible to molecular mimicry and we know these variants to be overrepresented in #LongCOVID, #MECFS, #fibromyalgia and some primary autoimmune diagnoses. And many other genes that affect immune function as well have been seen to cause a propensity for an outsized IgG 24/
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response to herpesviruses: TNF-alpha promotor genes, IL-6 and IL-10 promoter genes, IRF5, STAT4, KIR, C4A and probably more. TLDR: An abnormally elevated set of herpesvirus titers in a chronically ill person should be the START of a detailed investigation, not the end. 🙏 /end
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