NCCN POTENTIAL ACTIONABLE THERAPEUTIC BIOMARKERES: PART 1 #NCCN #BIOMAKERS #Therapeutics #FDA #ASCO #IASLC #WHO #NEET #NEETSS #pathology #pathognosis

Cervical spinal lesion in a middle-aged woman. Diagnosis? (Feel free to snack on some CAPNON Crunch cereal while you're thinking about it.) #pathology #neuropath #PathTwitter

40s M with testicular swelling. Diagnosis? #PathX #PathTwitter @MGBpathology @MGHPathology

Orchidectomy, adult #GUpath #GIpath #Pathresidents #pathwtitter

#MMR IHC interpretation guideline from #BAGP #pathology #IHC #MSI #pMMR #dMMR #pathognosis #genetics

A primer on Splenogonadal Fusion: mayoclinicproceedings.org/ar…

Hypercalcemia in sarcoidosis

Low-grade B-cell lymphomas may present with prominent reactive inflammatory infiltrates or coexist with autoimmune disorders ⚠️ Increased IgG4:IgG ratio? Stop and think before diagnosing IgG4-related disease. Always exclude an associated lymphoproliferative disorder What is the cause of abundant IgG4 in lymphomas?Possible explanations... 1. Non-neoplastic IgG4 cells within the tumor microenviroment 2. Monoclonal IgG4 production by lymphoma 3. Lymphoma can coexist with IgG4-related disease and other autoimmune disease Dr. Herrera Hernandez #USCAP2026 #pathology #PathX #PathTwitter

Utility of p53 IHC in daily routine practice ! #p53 #IHC #pathology #pathognosis #NEET #NEETSS

💡 Mastering Hamartomatous Polyps & Syndromes! Keeping your polyposis syndromes straight is absolutely high-yield for pathology boards. These essential clusters split cleanly by inheritance and type

🧬 Next-Generation Sequencing (NGS) has revolutionized modern oncology. From identifying actionable mutations and tumor-agnostic biomarkers to detecting minimal residual disease (MRD) and resistance mechanisms, NGS is the cornerstone of precision cancer medicine. 🎯 What can NGS detect? ✅ EGFR, ALK, ROS1, RET, NTRK alterations ✅ MSI-H & TMB-high biomarkers ✅ Germline mutations (BRCA1/2, TP53, PALB2) ✅ MRD and ctDNA ✅ Resistance mutations such as EGFR T790M 💡 Remember: TARGET MRD 🔹 T – Targetable mutations 🔹 A – Agnostic biomarkers 🔹 R – Resistance mechanisms 🔹 G – Germline mutations 🔹 E – Evaluation of prognosis 🔹 T – Tissue of origin 🔹 M – MRD detection 🔹 R – Recurrence monitoring 🔹 D – Drug selection Precision oncology is shifting treatment decisions from “where the cancer started” to “which molecular alteration is driving it.” #NGS #PrecisionOncology #CancerGenomics #MedicalOncology #MolecularOncology #LiquidBiopsy #ctDNA #MRD #TargetedTherapy #Immunotherapy #GenomicMedicine #CancerEducation #OncologyTraining #OncologyPearls #DrRupamManna #CancerConceptsExplained

A Systemic Approach to Histopathology Slides 🔬

Lung **Reactive pneumocytes vs malignant cells** Reactive - Spectrum of atypia - Cytoplasmic vacuolization - Maintained N/C ratios - Cytology: Napoleon hat sign Dr. Sauter #USCAP2026 #pathology #PathX #PathTwitter

**Pediatric acinar cell carcinomas** - 10% of pediatric ACC can be associated with Cushing syndrome - They are associated with increases in AFP serum levels - Aggressive neoplasms - Morphologically they look like neuroendocrine tumors Dr. La Rosa #USCAP2026 #pathology #PathX #PathTwitter

Adult male. Retroperitoneal mass. #PathX #PathTwitter #BSTPath

'Feelin' Groovy' - florid urothelial metaplasia in a prostate needle biopsy, mimicking basal cell hyperplasia and HGPIN at low magnification; at high magnification cytoplasmic vacuoles (upper R) & nuclear grooves (lower R) in the metaplastic cells aid in identification #gupath

Epithelioid features can be seen in a variety of lesions- let's review: What is your interpretation? A. Epithelioid sarcoma B. Epithelioid histiocytoma C. Epithelioid angiosarcoma D. Epithelioid hemangioendothelioma #PathPearls #PathQuiz

Esophagitis dissecans (sloughing esophagitis). The detached portion of the epithelium loses its glycogen!

Mastocytosis (seen here) is often sought by naive colleagues and seldom seen. Mod Pathol offers a great review: Panarelli NC, Hornick JL, Yantiss RK. What Is the Value of Counting Mast Cells in Gastrointestinal Mucosal Biopsies? Mod Pathol. 2023 Feb;36(2):100005. PMID: 36853780.

🧬 ANA Patterns at a Glance 🔵 Homogeneous → Lupus 🟣 Speckled → Mixed autoimmune disease 🟢 Centromere → Limited scleroderma 🟠 Nucleolar → Systemic sclerosis 🔴 Cytoplasmic → Myositis ⚠️ ANA pattern alone does NOT diagnose disease. #MedTwitter #Rheumatology #ANA #Autoimmunity #MedicalEducation #FOAMed