I am pleased to tell you that a Frontiers e-book, comprising all the articles featured in the Research Topic titled Research Topic Ketogenic Metabolic Therapies in Prevention & Treatment of Non-communicable Diseases has been compiled and is now available online on the @FrontNutrition website! frontiersin.org/research-top…

Thiamine is not used to build the enzyme protein alpha-ketoglutarate needed to make ketones. It is used to make thiamine pyrophosphate, TPP, which is a required cofactor for the alpha-ketoglutarate dehydrogenase complex. With low thiamine, alpha-ketoglutarate dehydrogenase may still be present, but its activity can fall because it does not have enough TPP. That complex helps move carbon through the TCA cycle and generate reducing equivalents for mitochondrial energy production. Thiamine → TPP → TPP sits on E1 → TPP TPP is the “carbon-handling” cofactor for the E1 step. It does not build the enzyme alpha-ketoglutarate dehydrogenase. It lets the enzyme perform the difficult chemistry of alpha-keto acid decarboxylation. Keto does not bypass the thiamine-dependent downstream mitochondrial oxidation step. That means a person can still make ketones, measure ketones, be “in ketosis” and yet still have impaired energy extraction from that fuel if thiamine-dependent mitochondrial enzymes are not working due to thiamine insufficency or deficiency. Thiamine insufficiency and even deficiency is common. Its treated based on symptoms more than testing. I put people on good quality supplementation as supports to their ketogenic diet for healing in my online program for this reason. So in closing, no low thiamine will not impair your ketone levels the way carnitine insufficiency will. But it will impair the energy production you were hoping to experience in your ketogenic diet. And as we all know from dear @MitoPsychoBio with his latest substack this morning, energy matters.

In a world where you can be anything, be a number 50

This line from Carl Jung may contain the most wisdom in the fewest words ever

Even though I knew his death was coming, as he told us it would, I still can’t believe he has died. Rest in peace, good and great man, rest in peace.

We loved you back, Scott.

Convincing your girlfriend she's crazy or paranoid is called gaslighting, and it's a dick move. But convincing her she's a robot with artificially implanted human emotions is called Bladerunning. It's a Phillip K. Dick move.

The official new Dietary Guidelines food pyramid Revolutionary. Grains now at the bottom

Some people think ketogenic diets are restrictive and that any kind of restriction is bad. But I think we need a short thread defining what food is and is not. 🧵(1/11)

Evidence-Based Medicine Was Never Meant to Silence Patients. If you have been told “not enough evidence” when you asked for ketogenic metabolic therapy support, this is for you. Real evidence based medicine includes your values, shared decisions under uncertainty, and N of 1 logic. mentalhealthketo.com/2025/12…

your brain wants to hear your newest favorite song over & over, not just because you like it, but because it's fixing something

The only real test of intelligence is if you get what you want out of life.

Rest in peace Doc! Thanks for taking the time to look into this subject that affects so many. Your presence will be missed but not forgotten

One of the best uses of your time on this planet is to help other people avoid the same mistakes you did. If you can't be a great inspiration, be a terrible warning.

Caught my mom listening to something while walking on the treadmill. I was wondering why she was listening to a podcast speaking about olive oil in glowing terms. "What is that?" .. Turns out she finally decided to listen to @drcateshanahan's book "Deep Nutrition"!

And Microsoft is still submitting more requests for H-1Bs.

It's published! The energy model of insulin resistance: A unifying theory linking seed oils to metabolic disease and cancer Here’s the link to the full text. Let’s make this the most downloaded paper on their website!! Here’s my summary: The paper proposes that seed oils, by causing oxidative stress, force cells to change their fueling strategy. The result of that is metabolic disease and cancer. It works like this: Oxidative stress suffocates cells. It puts them into a kind of survival mode, and activates genes for bringing sugar into the cell. That's called aerobic glycolysis, which is now understood to be the main mechanism driving cancer! At the whole-person level, many cells stealing sugar from the bloodstream all at once lower our blood sugar. That causes hypoglycemia, and then you get a flood of stress hormones. This is immediately practical. Wonder why you feel hangry? That's why. And yes it means you have insulin resistance. Cancer and insulin resistance share the same root cause. So if you get hangry, you are at higher risk of cancer. This paper explains why insulin resistance and cancer are rampant among youth. They were tragically born and raised on more processed foods than any previous generation. Seed oils are the worst ingredient in processed foods. I tried to make the theory airtight. But I appreciate anyone who wants to poke holes. Writing this paper consumed many hours over the past few months. Keeping me away from terribly important things, like posting on X. Read the full text here: frontiersin.org/journals/nut…

My academic paper has been accepted for publication! I hope this will shake up the conversation on seed oils. They are the most harmful toxin in our food supply. Savvy food consumers are way ahead of doctors, nutrition researchers, and dietitians on this, and these academics also deserve to know the truth they've been denied.

Tomorrow Feb 10 is the deadline for weighing in on the @USDANutrition guidelines by signing this petition and/or leaving a public comment. Let your voice be heard.

People who appear a little too perfect followed the rules and didn’t take enough risks. A man in his prime should have some scars.