Hold on to your🧦! In this trailblazing study @CellStemCell, we engineered a super-reprogramming factor that induces higher developmentally potent cells across species. Check out our super-SOX, how it works, and how many species we reprogrammed and reset to naive pluripotency.

Great listen with @dwarkesh_sp and @jacobkimmel. Thanks for explaining super-SOX and the potential of synthetic reprogramming factors for age reversal!

Excited about @geochurch lab's latest paper at @emboreports, where I collaborated with @mpsmela1 to combine super-SOX naïve reset with his new set of factors to improve production of human oogonia - advancing towards iPSC-derived in vitro egg generation 🥚👶 embopress.org/doi/full/10.10…

Proud to see this out now. We tried to give this topic a different perspective, put more weight on the MD simulations and NMR and look forward to the future that we believe should focus on dynamics. link.springer.com/article/10…

But can it run a gel?

Our Matters Arising preprint highlights the following issues with the Transient Naive Treatment (TNT) method for improved generation of human iPSCs published @Nature : 1. Characterization of bulk iPSCs rather than clonal iPSC lines; 2. Persistent Sendai virus expression in most samples even as late as passage 17; 3. Naive medium selects for high levels of Sendai resulting in overexpression of SKM @thermofisher , we need a better CytoTune design! #notmySendai biorxiv.org/content/10.1101/… thanks to @delosangeles520 , @clemens_hug , @VadimGladyshev , @geochurch @harvardmed @MIT TNT paper : nature.com/articles/s41586-0… by @sambuckberry , @ry_lister , Jose Polo & colleagues

And in the roundup: 1) A GENtoniK cocktail 🍸 @ejhergenreder @studerl @MSK_CSCB 2) Pancreatic organoids ♋️ @WCMSurgery @CellStemCell 3) Mammary organoids 🧫 @NCIResearchCtr @Dev_Cell 4) Chimeric super-SOX 🧦 @velychko_s @seemaccarthy

Super thrilled to announce our latest breakthrough! Introducing gamechanger #supersox that enhances iPSC quality & generation from various species🐁🐖 🐄🐒👴🏼👵🏼 thnx @velychko_s @seemaccarthy @jauchr @geochurch Hans Scholer #StemCellResearch #breakthrough sciencedirect.com/science/ar…

1. In the beginning there was Sox, and the Sox was Sox2. A billion years later we created super-SOX: dlvr.it/T0V194 Merry SOXmas! 🚀🧦

Online Now! Highly cooperative chimeric super-SOX induces naive pluripotency across species dlvr.it/T0V194 #stemcells

Congrats to @haoqing_hu who led a team to show why it needs SOX17 rather than SOX2 to generate pluripotent and multipotent stem cells with high efficiency and quality @NAR_Open @hkumed academic.oup.com/nar/article…

Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. elifesciences.org/inside-eli…

Ever wonder what transcription factors look like in action? Our study sheds light on the interplay between Oct4, histone tails, and nucleosomal DNA. Thanks @cojocarulab @janhuemar & all authors! #allyouratomsareshowing #multidomainsTFshavemorefun(ctions) doi.org/10.1093/nar/gkac755

Honored to present our unpublished work on enhancing the Yamanaka cocktail to Shinya Yamanaka himself at #GSCN2022, and to win a poster prize 🥂 Thanks to @seemaccarthy for her great contribution to the project and for capturing the moment :) @gscn_office

Nobel laureate Shinya Yamanaka giving a lecture at the 10th @gscn_office and 20 Years @StemCellsNRW meeting. What an honour that he came all the way from Japan! @MKW_NRW @MPI_Muenster #GSCN2022

The #GSCN2022 Conference & 20 years @StemCellsNRW has started! Great opening by Hans Schöler @MPI_Muenster and Fiona Doetsch. Looking forward to exciting 4 days. #stemcells @berlinnovation

A great kick off for the German Stem Cell Network Meeting 2022. @MPI_Muenster #nonPImeeting #GCSN2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. Fine collaboration of @LeXiong @lidschreiber @taras_velychko @LCaizzi with Schöler lab. doi.org/10.7554/eLife.71533 @eLife

After 6 months of work, I'm happy to share a much improved article with lots of new data further strengthening our conclusions. Its great to see the progress from preprint versions. Thanks especially to @seemaccarthy and @janhuemar for this effort. biorxiv.org/content/10.1101/…