Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve Parkinson’s symptoms. "This is an important milestone on the road towards regenerative brain repair," says Dr. Tabar. "It represents more than two decades of collaborative work, based on very rigorous science beginning in our labs." Learn more: bit.ly/3EvfKbB bit.ly/4lxH2yC

Things I wish more people knew about doing science in the US (thread):

Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine science.org/doi/10.1126/scit…. It was exciting to see this story develop from way back.

👏 Congratulations to Dr. Deb Schrag, Chair of the @MSK_DeptOfMed, and Dr. @studerl, Director of the Center for Stem Cell Biology at MSK, who were elected to the @theNAMedicine, one of the highest honors bestowed upon scientists worldwide. Learn more: bit.ly/4fvwkoP

📢 Join us! Developmental and stem cell biologists, checkout our tenure-track faculty position at Sloan Kettering. Apply by October 18. #DevBio #StemCell #hiringnow mskcc.org/research/ski/posit…

Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. @MSKCancerCenter @MSK_CSCB @MSKEducation biorxiv.org/content/10.1101/…

This was a great episode indeed. Congrats to @bigosi and @TabarViviane

Congratulations to Dr. Shuibing Chen (@ChenShuibing) on her lab's new @CellStemCell paper! Her team developed vascularized macrophage-islet #organoids to study damage from infection. Read the article: bit.ly/4gqAcJ1 Learn more about her work 👇 bit.ly/3MuyPex

Exciting opportunity for open tenure track positions in Developmental Biology & Stem Cell Biology @MSKCancerCenter (see Ad - go.nature.com/3yOv8gx). Deadline for applications is October 14, 2024 (facultysearch.ski.edu)

Great postdoc opportunity if you are interested in developing next gen human PSC based cell therapies for brain repair here at MSK

Excited to see the work published @Nature. Excellent summary in thread below. Big collaborative effort with @ShenYingZhang1, @casanova_lab many more. Special thanks to @yihaoo, @ZhiyongLiu7, Paul Bastard and in my lab @NoopurKhobrekar, Param Amin, @gabriele_ciceri & @harschnitz

Excellent thread from @ShenYingZhang1 on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz

Look, it’s the @studerl lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩

Super excited to see this study finally published after many years of work. Congrats to @NatSaurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and @ASAP_Research.

How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA

Excellent thread from @_SoyeonKoo on the paper (and also her thesis work 😊). Congrats!

@CellCellPress @TaeWanKim0 @studerl Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease cell.com/cell/abstract/S0092…

Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. biorxiv.org/content/10.1101/…

Why do most dopamine neurons die shortly after transplantation and how can we fix it? Excited to see our story out at Cell. Congrats to @TaeWanKim0 & SoYeon Koo @MSKCancerCenter and to all the other collaborators who made this work possible. cell.com/cell/fulltext/S0092…

Excellent to hear that the FDA gave RMAT designation to DA-01 (Bemdaneprocel) following the promising 18-month data in 12 patients from the BlueRock-sponsored dopamine neuron cell therapy trial in advanced PD – see also article below and BR press release bit.ly/4c4QsMC