“We are dream builders. We’re not dream killers.” Ben Horowitz on a16z's written culture that forbids publicly attacking founders or startups: “We have a culture that is written culture... You cannot join the firm unless you sign the culture document that says you'll adhere to this culture.” “Our whole point is, if you want to do something larger than yourself and make the world a better place, we are a hundred percent for it.” @bhorowitz @packyM

It all begins with a great idea.

In 1922, a group of scientists went to the Toronto General Hospital where diabetic children were kept in wards, often 50 or more at a time. Most of them were comatose and dying from diabetic ketoacidosis. Others were being treated by being placed on an extremely strict diet, which inevitably led to starvation. This is known as one of medicine's most incredible moments. Imagine a room full of parents sitting at the bedside waiting for the inevitable death of their child. The scientists went from bed to bed and injected the children with a new purified extract: it was called insulin. As they began to inject the last comatose child, the first child injected began to awaken. Then one by one, all the children awoke from their diabetic comas. A room of death and gloom became a place of joy and hope. In the early 1920s Frederick Banting and Charles Best discovered insulin under the directorship of John Macleod at the University of Toronto. With the help of James Collip insulin was purified, making it available for the successful treatment of diabetes. In the same year, Banting, Collip, and Best decided to sell the insulin patent to the University of Toronto for $1. Banting and Macleod earned a Nobel Prize for their work in 1923. Photo Credits: Library and Archives Canada

Some towns threatened 15 days in jail for crossing the street with headphones on: newsletter.pessimistsarchive…

In 1995 a group of NASA scientists studied the effects of various drugs on spiders, specifically on the way they weave their webs. 🤨 The LSD one looks good. The Caffeine seems to be more messed up than the one on Speed 😂 The Marijuana spider got halfway done and gave up.

4. Economic Moat A strong economic moat exists when there's a long-term competitive advantage. Moat protects a company's profitability and growth from competition. Examples: •High switching costs •Economies of scale •Network effects •Regulations •Branding

HALF of all men and a THIRD of all women in the US will develop some form of cancer in their lives. So, what can we do about it? The Hidden "Cure" for Cancer - new episode of Huge If True out now: youtu.be/USmu0scNcSs

'Last Stand' is a sci-fi short film directed by Hashem Al-Ghaili and made with AI using Brightpen.ai with music by Thiago Nugent [HD version read more: buff.ly/3M8JJYd] x.com/notTobi_/status/164206…

Steve Jobs always talked about hiring "the best people” But how do you know if someone is exceptional? Here are 10 non-obvious signals to find high-performing talent: