Asymmetric Synthesis of Noncanonical Prolines via a TrpB-IRED Enzymatic Cascade

Noncanonical amino acids (ncAAs) are valuable building blocks for therapeutic design. Prolines are particularly useful because their cyclic cores can limit the conformational flexibility of a larger...

O-Vinylhydroxylamines for De Novo Pyrrole Synthesis

Regioselective access to electron-deficient and highly substituted pyrroles from simple building blocks remains challenging. Here we show that O-vinylhydroxylamines enable the de novo construction of...

Enzymatic Access to Norstatines by PLP-Dependent Decarboxylative C–C Bond Formation Involved in...

Norstatine (α-hydroxy-β-amino acid) is a valuable scaffold found in bioactive molecules and is particularly important as a peptidase inhibitor. Although several natural products containing norstatine...

Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent...

Triazolopyridines are an important class of heterocycles in the pharmaceutical industry and materials sciences. In particular, [1,2,3]triazolo[1,5a]pyridines have emerged as stable and versatile...

Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape

Reactive aldehyde metabolites are commonly viewed as drivers of nonspecific protein damage and stochastic cross-linking. Here, we show that cooperative aldehyde chemistry can generate multicomponent,...

Chlorination of Amines by a Vanadium-Dependent Chloroperoxidase

Organic chloramines are an important class of compounds containing a covalent nitrogen–chlorine bond. Despite the growing interest in their applications in small molecule synthesis and polymer...

Some Items of Interest to Process R&D Chemists and Engineers