Joined January 2026
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🦋 Strain meets electrochemistry ⚡️🔋: Electrochemical strain-release difunctionalization of azabicyclo[1.1.0]butanes with nitroarenes forges densely functionalized aza-cyclobutanes, transforming latent strain into molecular sophistication 🚀
@J_A_C_S
doi.org/10.1021/jacs.6c06427
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Strained Rings retweeted
Jun 5
Happy😃to share our latest on BCB🦋: (3 3) Annulation with mercaptoCH3CHO to access 2-thiaBCHeps, just out @JOC_OL!
pubs.acs.org/doi/10.1021/acs…
Kudos Anisha, Palash & @123shashankkk 👏
See also the independent work from @Jian_Jun_Feng group: nature.com/articles/s41557-0…
@iiscbangalore
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Strained Rings retweeted
May 29
Ladderanes: Stepping Up as Nonclassical ortho-Substituted Benzene Bioisosteres | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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🦋 Strain-driven radical elegance : NHC catalysis unlocks bicyclo[1.1.0]butanes for radical alkylarylation, forging densely functionalized 3-spirocyclobutyl oxindoles through controlled release of ring strain 🚀
@ChemCommun
doi.org/10.1039/D6CC01634K
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Strained Rings retweeted
May 13
Diastereoselective Synthesis of Difluoromethylene—Bridged Cyclopropane-Cyclobutanes from 2-(Difluoromethylene)-cyclobutyl Sulfonium Salt and Cyclopropenes
doi.org/10.1002/cjoc.70605
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𖣘 Photochemical chloro-sulfoximidation unlocks the extreme strain of [1.1.1]Propellane, enabling radical difunctionalization into densely functionalized BCPs – light-driven access to high-value 3D bioisosteres 💡
@ChemCommun
doi.org/10.1039/D6CC01651K
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🦋 Dihalogenation-triggered strain-release cyclization of BCB carboxamides enables rapid assembly of dihalogenated spiro[cyclobutane-quinolinone] frameworks, extreme BCB strain sculpted into medicinally rich 3D architectures ⚡
@ChemCommun
doi.org/10.1039/D6CC01504B
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🦋 Electrochemical anodic oxidation triggers relay cyclization to forge strained 2-oxa-bicyclo[2.1.1]hexanes, transforming simple precursors into rigid 3D bioisosteres—electrons unlocking strain-built molecular architecture ⚡🔋
@ChemicalScience
doi.org/10.1039/D6SC03129C
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🦋1-Azabicyclo[1.1.0]butanes emerge as “spring-loaded” synthons for azetidine construction, where strain-release drives modular ring opening, skeletal editing & rapid access to sp³-rich N-heterocycles ⚡🔺
@ChemEurJ @Luisi_Lab
doi.org/10.1002/chem.71087
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Strained Rings retweeted
May 7
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🔺Strain rewrites diazo chemistry ⚡! Cyclopropanediazonium intermediates trigger ring-opening rearrangement, enabling fluorinative migration to access difluorinated scaffolds: small rings, bold reactivity 💥🔥
@angew_chem
doi.org/10.1002/anie.7578090
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🔺 Cu-catalyzed chemodivergent ring-opening diborylation of strained vinylcyclopropanes exploits cyclopropane strain to forge distal 1,5-diboronates: ligand-controlled selectivity enables precise C–C cleavage and multifunctionalization ⚡
@ACSCatalysis
doi.org/10.1021/acscatal.6c0…
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🦋 One strained BCB, two fates 🔺⚡! Catalyst choice (Ni vs Cu) directs carbene transfer: cyclopropanation or C–H insertion—harnessing “spring-loaded” strain for divergent, high-precision synthesis 💥🧪🔥
@angew_chem
doi.org/10.1002/anie.9286701
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🦋 Strain-encoded reactivity of bicyclo[1.1.0]butanes exploited in a Yb(OTf)₃-catalyzed Schmidt–semipinacol sequence: controlled C–C bond cleavage/migration delivers architecturally complex N-heterocycles 🔥
@JOC_OL
doi.org/10.1021/acs.orglett.…
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🔺Carbonyls → carbenes → cyclopropanes ⚡ ! Fe catalysis converts simple aldehydes/ketones into strained cyclopropanes—no diazo, just elegant strain-building from everyday feedstocks 💥🔥
@J_A_C_S @MacMillan_Lab @PrincetonChem
doi.org/10.1021/jacs.5c21614
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🦋⚡Electrochemical activation unlocks strain-release of 1-azabicyclo[1.1.0]butanes, generating N-centered radical cations for divergent functionalization: electrons sculpt azetidines with precision and synthetic elegance 🔋
@angew_chem @PB_IITRPR
doi.org/10.1002/anie.5707597
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🦋 BCB strain goes alkyne-active ⚡! Phosphine catalysis drives strain-release alkynylation, converting tiny high-energy rings into richly functionalized cyclobutanes — small rings, massive synthetic power 💥🔥
@AdvSynthCatal
doi.org/10.1002/adsc.70472
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Strained Rings retweeted
Great to see our recent @J_A_C_S paper about the synthesis of 4-members rings from alkenes pubs.acs.org/doi/10.1021/jac… highlighted as Synfacts of the Month thieme-connect.de/products/e… thanks @thiemechemistry for the recognition and well done to the team!
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𖣘 Rh(II) drives cascade annulation to build strained [4.3.1]propellanes—small-ring strain carbene reactivity = explosive access to complex polycycles
@JOC_OL
pubs.acs.org/doi/10.1021/acs…
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🔺Strain forged under light : A photoredox-neutral acridine/Fe dual catalysis enables decarboxylative carbene generation, driving cyclopropanation—transforming simple acids into highly strained rings with elegance & efficiency 🚀
@ACSCatalysis
doi.org/10.1021/acscatal.6c0…
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