m6A RNA Modification in Colorectal Cancer: Regulatory Roles, Oncogenic Signaling, and Metabolic...

N6-methyladenosine (m6A), the most prevalent internal RNA modification in eukaryotic cells, is a dynamic regulator of RNA metabolism and cancer biology. In colorectal cancer (CRC), dysregulated m6A...

Chronotype and Daytime Sleepiness in Women with Hashimoto’s Thyroiditis: A Cross-sectional Pilot...

Hashimoto’s thyroiditis (HT), an autoimmune disease with a prevalence 2–7 times higher in women than in men, is associated with daytime sleepiness. The present study aimed to test the hypothesis that...

Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy...

Immunothrombosis, the interplay between immune activation and coagulation, contributes to disease progression in inflammatory disorders. Its role in hepatitis B virus–related acute-on-chronic liver...

Letter to the Editor: Celiac Disease Diagnosis Pitfalls — Pediatric Pathways, Refractory Stratifi...

Artificial Intelligence in Breast Pathology: Recent Advances in Multimodal Models, Explainability,...

Artificial intelligence (AI) is increasingly reshaping diagnostic pathology, with breast pathology representing one of the most advanced and clinically impactful areas of adoption. Despite rapid...

A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic...

The immunosuppressive tumor microenvironment (TME) limits immunotherapy efficacy in intrahepatic cholangiocarcinoma (ICC). Understanding the molecular drivers of this TME is essential for developing...

Perioperative Anaphylaxis: Etiology, Pathophysiology, Diagnostic Challenges, Immediate Management,...

Perioperative anaphylaxis is a rare, life-threatening, iatrogenic condition that predominantly arises following anesthesia. The unique context of this condition, characterized by the concurrent...

Development and Successful Treatment of Spinal Mixed Histiocytosis in an Elderly Woman following...

Development of mixed histiocytosis (Langerhans cell histiocytosis (LCH))/Erdheim–Chester disease (ECD)) after treatment in patients with an initial skull LCH lesion has not been well recognized. An...

The Future of Artificial Intelligence-driven Personalized Nutrition in Gastroenterology and...

Nutrition plays a pivotal role in the prevention and management of gastrointestinal and hepatic diseases, yet dietary guidance remains generic, limiting its effectiveness. Conditions such as inflam...

Signaling Pathways in Pancreatic Stellate Cell Activation: A Review of Therapeutic Mechanisms by...

Pancreatic fibrosis, a major pathological feature of chronic pancreatitis, is primarily driven by the abnormal activation of pancreatic stellate cells (PSCs) and excessive deposition of extracellular...

Guidelines for the Diagnosis and Treatment of Pediatric Low-Grade Gliomas in China (2024)

Pediatric low-grade gliomas (pLGGs) exhibit distinct biological and clinical characteristics compared to adult gliomas, and their treatment strategies differ substantially from those used in adults....

Associations of Normalization and Regularization with Machine Learning Overfitting in Cross-dataset...

Normalization can standardize and improve machine learning (ML) performance on omics data. However, it is unclear whether normalization is associated with overfitting (i.e., worse cross-dataset...

Inhibition of Bromodomain and Extra-Terminal Domain Proteins in Solid Tumors: Advances, Challenges,...

The bromodomain and extra-terminal domain (BET) protein family, particularly BRD4, is critical for the control of oncogenic transcriptional programs in solid tumors. Although initial-generation BET...

Helicobacter pylori and Gastric Cancer: A Potential New Paradigm of 3R (Remove, Remodel, Repair)...

Helicobacter pylori infection represents a significant modifiable risk factor in the pathogenesis of gastric cancer. Nevertheless, conventional antibiotic treatments have increasingly proven inadeq...

Micro- and Nanoplastics: A Paradigm Shift in the Pathogenesis of Inflammatory Bowel Disease

Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing recognition as potential contributors to human disease. Widespread human exposure occurs primarily through...

Modified Gengnianchun Formula Outperforms Androgens in Treating Chronic Stress-Induced Diminished...

Chronic stress-induced hypercortisolism causes diminished ovarian reserve (DOR), contributing to infertility and miscarriage. Androgen supplementation is an emerging therapeutic approach for DOR. The...

Obstructive Sleep Apnea and Lung Cancer: Epidemiological Insights and Pathophysiological Mechanisms

Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which may contribute to lung cancer development and progression. This review...

Impact of Prolonged Ischemia and Fixation on the Immunohistochemical Expression of PD-L1 in...

Ethanol Extracts of Justicia carnea Leaves Mitigate Pancreatic Oxidative Stress and Preserve Islet...

Chronic pancreatitis is an inflammatory disease and is difficult to manage despite advancements in medical science. This study examined the effect of water/ethanol extracts of Justicia carnea leaves...

Optimizing Bowel Preparation in High-risk Patients Undergoing Colonoscopy: A Narrative Review

Identifying patients at high risk for poor bowel preparation preceding a colonoscopy is critical to successful colorectal cancer screening. High-risk patients, such as those who are obese, diabetic,...