Assistant professor @westlake_uni. Synthetic biology. Pilot (PPL, IR).
Joined June 2009
- Tweets 277
- Following 290
- Followers 1,636
- Likes 630
27 Photos and videos
Zibo Chen retweeted
May 21
Longer thread later, but if you are designing small proteins or want to building a stability predictor using 1.8 million highly diverse experimental measurements… credit to @ChoYehlin and @KotaroTsuboyama !
biorxiv.org/content/10.64898…
3
26
104
8,435
Zibo Chen retweeted
Apr 30
I'm very excited to share that I've started a new position as a Group Leader at CZ Biohub NY! @biohub
17
14
193
14,793
Zibo Chen retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
20
149
560
47,202
Zibo Chen retweeted
17 Nov 2025
Join us next March'26 at
Synthetic biology for Health and Sustainability
Abstracts deadline: December 1st, 2025
Link below 👇
Great lineup of speakers and excellent venue: Kristala Prather (MIT), Luis Serrrano (CRG), Priscilla Briquez (Freiburg), Zibo Chen (Westlake U) @ZiboChen , Tobias Erb (Max Planck), Cleo Kontoravdi (Imperial College), Debora Marks (Harvard), Nicola Patron (U of Cambridge), Sai Reddy (ETH), Anna Rising (Karolinksa), Edda Schulz (Max Planck), Claudia Vickers (Queensland U), Chris Voigt (MIT) @Geneticdesigner, Harris Wang (Columbia)
1
5
18
5,826
Thrilled to share our new paper on MASS (Multivalent Antigen Sensing Simulator)!
We built a fast and accurate simulator to calculate multivalent binding KINETICS from monomeric properties, enabling sensing of cell surface antigen types and densities.
pubs.acs.org/doi/10.1021/jac…
1
2
12
1,663
We also optimized the code to be fast, so you're not waiting hours to simulate higher valency binding kinetics. Code is available here: github.com/BioProgramming-La…
1
327
Huge shoutout to @DamonRunyon for funding this work. And check out this stunning cover art by the unstoppable first author, Xiaoyu, with a Haiku interpretation from Gemini:
Small bots read the stone
Linked by glowing, sensing wire
Many arms see one
1
342
Zibo Chen retweeted
7 Sep 2025
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of @MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be.
13
128
620
106,286
Zibo Chen retweeted
28 Mar 2025
LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.
5 May 2024
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
5
17
105
19,878
Zibo Chen retweeted
2 Jan 2025
🚨NEW PUBLICATION ALERT🚨: In a paper out today in @ScienceMagazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/scie…. 🧵1/n
2
62
251
48,486
Excited to finally share Perceptein, a PERCEPtron made of proTEINs: science.org/doi/10.1126/scie…
9
50
196
38,204
It was tremendous fun brainstorming with @ElowitzLab in the early days of this project, and collaborating with all co-authors on this paper. A nice cover art made by the talented Ehmad Chehre:
1
9
1,077
Finally, thanks to @GallowayLabMIT and Christopher Johnstone for this thoughtful perspective. We are indeed excited about the "learning/training" aspect of the Perceptein network! science.org/doi/10.1126/scie…
2
1
8
746