Director NCI-designated Cancer Genome and Epigenetics Program at SBP, Co-Editor-in-Chief Aging Biology Journal, Road/Gravel/Mtn Cycling, Wolf Pack Cycling.
Joined August 2020
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27 Sep 2023
New road bike. S-WORKS Tarmac SL7, Campy SR wireless and disc, Campy Bora Ultra WTO wheels👍 No excuses now😧
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These studies are very exciting. See also here from Nate Basisty @sennetresearch
x.com/agingbiology/status/20…
A New Path to Preventing Cancer
A Landmark Study Showing the Way Forward
erictopol.substack.com/p/a-n…
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Peter Adams🇪🇺🇺🇳 retweeted
Jun 11
Explore the latest research from the NIH SenNet consortium, working to identify and characterize senescent cells across the human body, lifespan, and states of health and disease. @sennetresearch
View the collection: hubs.li/Q04l1Yd_0
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Congratulations Nate Basisty and @sennetresearch coauthors. I’m excited to see CCND1 in the top 20 unregulated genes in senescence. See here if interested in this apparent paradox biorxiv.org/content/10.1101/… Revised and improved MS coming soon.
Jun 11
Featuring a Commentary on how the SenNet consortium is building acomprehensive human reference framework for senescence
cell.com/cell/fulltext/S0092…
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Just back from the @sennetresearch Consortium meeting in Washington DC. There’s so much great research ongoing! These papers are the tip of the iceberg. Keep watching. Both @CellCellPress and @Nature family journals will have a package of papers.
Jun 11
Circulating senescent proteins and their prognostic value and an atlas of these cells
sciencedirect.com/science/ar…
linkinghub.elsevier.com/retr…
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Peter Adams🇪🇺🇺🇳 retweeted
Jun 11
Circulating senescent proteins and their prognostic value and an atlas of these cells
sciencedirect.com/science/ar…
linkinghub.elsevier.com/retr…
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Peter Adams🇪🇺🇺🇳 retweeted
Jun 4
Identifying an inflection point for Alzheimer's disease from the brains of 80 and 100 year old individuals. Microglia transition is key; initially it is protective vs inflammatory changes triggered by amyloid.
But microglia can turn destructive linked to tau. Resilience in older age, via two divergent pathways, prevents that transition. @NatureMedicine
nature.com/articles/s41591-0…
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@LocasaleLab Jason - I think the excitement over RAS inhibitors is that they are just the beginning. Similar to BRAF inhibitors and checkpoint inhibitors in melanoma 10-20 years ago. Surely melanoma is now in a much better place through these multiple incremental advances?
Jun 1
Another major advance vs cancer! @ASCO #ASCO26
Personalized neoantigen mRNA vaccine 5 year follow-up vs metastatic melanoma reduced recurrence and death by 49% (on top of Keytruda)
ascopubs.org/doi/10.1200/JCO…
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As someone who works primarily on aging and cancer, I take your points about lifestyle, prevention, early detection etc…. But I still think the ability to finally inhibit RAS is an achievement and only the beginning of something with lasting impact.
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Looks like a great meeting!
14 Oct 2025
📅 Save the date – October 22
Join us in Nice for the Workshop “Senescence & Immune Surveillance: Implications in Cancer and Aging”
🎓 Free participation – international speakers – lunch & networking!
#Senescence #Cancer #Aging #Immunology @ircaninstitute
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Super cool experiment. Activated Ras and inactivation of p53 in the heart = no cancer😂. Very interesting study
Apr 23
New @ScienceMagazine
Why is the heart resistant to cancer?
Role of the heart beat!
Mechanical force helps protect the heart from cancer
science.org/doi/10.1126/scie…
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I'm excited to speak at this meeting in Ireland in October this year. Looks like a great meeting! events.faseb.org/event/Chrom…
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Would be nice to have some functional measures to go with the clock data, but even so - seems like an exciting human study. Nice to see it coming from San Diego @UCSDHealth @MolinaLab1 Michael Corley and colleagues
Apr 20
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics
medrxiv.org/content/10.64898…
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This seems similar to @skhosla78 senolytic trial - potential benefits most marked in those with high baseline markers. pubmed.ncbi.nlm.nih.gov/3895… Patient stratification is important.
Revisiting changes in cognitive function and biomarkers of Alzheimer’s disease in REWIND alz-journals.onlinelibrary.w…
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Congratulations @FarzadNegin @RongFan8 and coworkers! Leaders within @sennetresearch. This is a comprehensive documentation of senotypes in the lymph node, important to discern “good” and “bad” senotypes.
Apr 15
Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches
biorxiv.org/content/10.64898…
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This is an excellent conceptualisation of epigenetics of aging. Takes a complicated topic and distills it down. Good to see histone H3.3 featured. For our latest contribution on histone H3.3 and aging see here biorxiv.org/content/10.64898… @NatureAging
Mar 28
This review is one of the most important syntheses in years. It doesn’t just catalog things. It proposes a unifying framework. ie. aging is a breakdown of epigenetic fidelity, the ability of cells to maintain correct gene expression over time...
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Peter Adams🇪🇺🇺🇳 retweeted
Mar 28
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target
nature.com/articles/s41580-0…
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Peter Adams🇪🇺🇺🇳 retweeted
Mar 29
p16High-expressing immune cells control disease tolerance as a defense and health span-extending strategy
cell.com/immunity/fulltext/S…
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Peter Adams🇪🇺🇺🇳 retweeted
🚨 #BSRA2026 is LIVE! Registration now open for our 75th Annual Meeting
📍 Oxford (Keble College)
Great science, great people, and some special 75th year surprises 👀
Tag someone who should be there!
🔗 meetinghand.com/e/75th-asm-o…
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I'm excited to be speaking at the Keystone Symposium on Inflammation Resolution in Whistler, British Columbia, Canada. Looking forward to great discussions! Register & submit abstracts here: keysym.us/KSInflammation26
@KeystoneSymp
#KSInflammation26
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A great meeting organized by Xiangmin Xu and colleagues at UC Irvine Center for Neural Circuit Mapping (CNCM)
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Peter Adams🇪🇺🇺🇳 retweeted
Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease
biorxiv.org/content/10.64898…
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