I've said many times mechanical hypertrophy is harmful for our health because it suppresses metabolic adaptation via JNK. You have more muscle at the expense of your health (mitohondria). link.springer.com/article/10… karger.com/ger/article-abstr… frontiersin.org/articles/10.…

Influence of the adaptation of lactate accumulation rate through physi… sciencedirect.com/science/ar…

Cystatin C is one of the better routine blood biomarkers for predicting longevity

The Role of Hypoxia in Longevity "...Hypoxia, marked by reduced oxygen availability, has emerged as a promising area of study within aging research..." pmc.ncbi.nlm.nih.gov/article…

High-dose vitamin D during pregnancy may lead to better cognitive performance in children. Mothers who supplemented with 2,800 IU/day of vitamin D had children with better verbal memory, visual memory, and cognitive flexibility at age 10 vs. children whose mothers supplemented with a standard dose of 400 IU/day.

Brain Aging and the Pursuit of Longevity: Biological Mechanisms and Clinical Implications aginganddisease.org/EN/10.14…

Effects of Velocity Loss Programming in the Bench Press on Strength Gains and Hypertrophy thieme-connect.com/products/…

This landmark paper from >10y ago prompted the idea that one should avoid screens before bedtime. Reading on a light-emitting eBook before bed doesn’t just delay sleep—it shifts your biology. 📱 Compared with printed books, evening screen reading suppressed melatonin, delayed circadian timing, reduced sleepiness, and impaired next-morning alertness. #Sleep #CircadianRhythm #DigitalHealth pnas.org/doi/abs/10.1073/pna…

Do Captions Affect Listening? Long-Term Effects on Listening Proficiency and Comprehension onlinelibrary.wiley.com/doi/…

Exercise doesn’t just strengthen muscles—it rewires immunity. Acute workouts and long-term training reshape immune cell behavior through exerkines, metabolites, blood flow, and even the gut microbiome, with implications for cancer, autoimmunity, and healthy aging. #ExerciseImmunology #Healthspan #Immunology sciencedirect.com/science/ar…

Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus "The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). In addition, supplementation significantly decreased the severity of insomnia among patients with diabetes by improving sleep duration." frontiersin.org/journals/end…

Deep sleep may be one of the brain’s most powerful anti-anxiety tools. Researchers identified a sleep-active circuit linking the parafacial zone, parabrachial nucleus, and BNST that suppresses stress-related signaling during slow-wave sleep and prevents anxiety-like behavior. #SleepScience #Neuroscience #MentalHealth sciencedirect.com/science/ar…

New preprint! We show that mTORC1 is critical for myofibrillogenesis and the radial growth of myofibrils in response to mechanical overload. biorxiv.org/content/10.64898… We also propose a model that redefines how mTORC1 might actually drive growth. Full breakdown in this thread 👇

New dose-response meta-analysis suggests that 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a more realistic and achievable target for some bit.ly/4uZOiHB

Centenarians show immune function found in younger individuals. Their immune system show reduced inflammatory signaling, enhanced autophagy, and controlled cellular senescence. They have low or no autoimmune disease, robust immunity against cancer and a distinct immune cell profile. Together, these adaptations help maintain immune balance and may offer clues for extending healthspan. nature.com/articles/s41577-0…

Sleep and ageing may follow a U-shaped curve: both short (<6 h) and long (>8 h) sleep were linked to faster biological ageing, higher disease risk, and greater mortality. Across multiple organs and omics measures, the “sweet spot” was ~6.4–7.8 hours/night. 😴 #SleepScience #HealthyAging #Longevity nature.com/articles/s41586-0…

Immunosenescence and human healthspan. Lessons from centenarians sciencedirect.com/science/ar…

Optimal Spacing for Types of Word Knowledge During Word Pair Learning journals.sagepub.com/doi/abs…

Exercise does far more than build strength or endurance—it activates molecular pathways that help regenerate muscle, heart, and brain tissue. Understanding these signals could pave the way for “exercise mimetics” that bring regenerative benefits to those unable to exercise. 🧬🏃 #Exercise #RegenerativeMedicine #HealthyAging @WuTsaiAlliance nature.com/articles/s41392-0…

Unveiling the perfect workout: exercise modalities and dosages to combat visceral adipose tissue in individuals with overweight and obesity - a systematic review with pairwise, network, and dose-response meta-analyses pubmed.ncbi.nlm.nih.gov/4209…

Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies nature.com/articles/s12276-0…