Joined January 2013
- Tweets 2,282
- Following 627
- Followers 2,854
- Likes 7,467
9 Photos and videos
Alexander Stark retweeted
May 30
Just want to give a shout-out to David Kelley @drklly who I think often does not get the credit he deserves (outside our core community).
I want to highlight why I think he is such a fantastic scientist and leader in regulatory genomics. 1/
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Alexander Stark retweeted
Apr 16
Not to mention the ridiculous move to open an "ERC Plus" scheme rather than invest more money into the already well functioning programs to fund more research.
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Alexander Stark retweeted
Apr 17
This gives incredible power to the panelists. They will literally determine if a lab survives or not with the 3 year ban. I don't think a couple of people should have this power. @ERC_Research
I don’t know if you saw the MASSIVE news announced by @ERC_Research today: from now on,if you get a B at step 1 you are eligible to apply at N 3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/ne…
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Alexander Stark retweeted
I don’t know if you saw the MASSIVE news announced by @ERC_Research today: from now on,if you get a B at step 1 you are eligible to apply at N 3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/ne…
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Alexander Stark retweeted
It's always nice to see more people in this space, but "barely touched territory" seems exaggerated. To design these enhancers, they use a model from a paper that also does AI-based enhancer design! And they provided wetlab validation of their sequences.
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Alexander Stark retweeted
The Programmable Genomics Lab at @UMassGCB
just officially launched our site!
We have a "simple" goal: to develop synthetic regulatory elements that target every cell type in every tissue, and control payload dosage/duration
Check it out!
programmable-genomics.github…
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Alexander Stark retweeted
Jan 28
The way to accelerate science is to SLOW it down.
Fewer papers please! We’re drowning in meaningless text.
One GREAT paper per lab per decade is more than enough.
q.e.d 👇
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Alexander Stark retweeted
Jan 28
AlphaGenome is out in @nature today along with model weights! 🧬
📄 Paper: nature.com/articles/s41586-0…
💻 Weights: github.com/google-deepmind/a…
Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: youtu.be/V8lhUqKqzUc
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29 Dec 2025
Join @fiddle, @MoffittLab, @sara_mostafav, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.a…
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Deadline extended to January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @CSHL (March 11-14). Register and submit your abstract here: meetings.cshl.edu/meetings.a…. Please Repost!
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Deadline TODAY January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @CSHL (March 11-14). Register and submit your abstract here: meetings.cshl.edu/meetings.a…. Please Repost!
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Alexander Stark retweeted
24 Dec 2025
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: biorxiv.org/content/10.64898… . Amazing collaboration by @TedChen1999CN, @Loubiere20 (@IMPvienna, @viennabiocenter), ... (1/2)
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Alexander Stark retweeted
30 Dec 2025
Now on bioRxiv: Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @FilipNemcko & Kevin Sabath in collab. with @plaschka_lab (@IMPvienna) biorxiv.org/content/10.64898… (1/2)
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Alexander Stark retweeted
29 Dec 2025
Join @fiddle, @MoffittLab, @sara_mostafav, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.a…
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Alexander Stark retweeted
29 Dec 2025
Read the full story in our preprint! 👇
biorxiv.org/content/10.64898…
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the @AlexanderStark8 and @plaschka_lab labs! 🤝🧪
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Alexander Stark retweeted
29 Dec 2025
Using Hcfc1 as a model, we show it functions as a molecular bridge: it connects CGI-bound TFs directly to TFIID. This recruitment overcomes a rate-limiting step unique to CGI promoters, enabling transcription initiation. 🧬🌉
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Alexander Stark retweeted
29 Dec 2025
Do transcriptional activators work on any promoter? Our data says no. 🙅♂️
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
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30 Dec 2025
Now on bioRxiv: Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @FilipNemcko & Kevin Sabath in collab. with @plaschka_lab (@IMPvienna) biorxiv.org/content/10.64898… (1/2)
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30 Dec 2025
I have always been fascinated by transcriptional activators that display intrinsic specificity towards some but not other promoter types as these imply alternative mechanisms! Hcfc1 directly bridges TFs to TFIID to overcome a rate-limiting step and activate CGI transcription.
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