Scientist in cancer genomics and computational discovery at @FoundationATCG. All opinions are my own. š³ļøāš he/him.
Joined September 2015
- Tweets 206
- Following 190
- Followers 216
- Likes 931
16 Photos and videos
Alexander Fine retweeted
1 Aug 2024
#Research in @TheLancet showcased positive results of CUPISCO, a randomized, precision oncology study designed to prospectively assess the efficacy of molecularly guided therapy in patients w/ unfavorable subsets of cancer-of-unknown-primary. Learn more: bit.ly/3yoGFml
1
2
336
Alexander Fine retweeted
4 Jul 2024
Today in @ScienceMagazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10
science.org/doi/10.1126/scieā¦
17
133
695
288,448
Alexander Fine retweeted
26 Jun 2023
Hot science! Look at the separation of those curves!
Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer academic.oup.com/oncolo/artiā¦
8
9
2,086
Alexander Fine retweeted
24 Jun 2023
5
14
1,807
Alexander Fine retweeted
2 Jun 2023
#Announcing the launch of FoundationOneĀ®Monitor* for research use in retrospective studies - available for biopharma customers, test provides unique access to our ctDNA tumor fraction biomarker: bit.ly/3MPXSsb
*Research Use Only. Not for use in diagnostic procedures
4
7
1,905
Alexander Fine retweeted
27 Mar 2023
A #machinelearning model that utilizes longitudinal #ctDNA metrics robustly predicts survival in two phase 3 trials of patients with metastatic #NSCLC, which may improve therapy selection and risk stratification. @genentech
nature.com/articles/s41591-0ā¦
1
28
68
17,263
Alexander Fine retweeted
17 Mar 2023
I am so glad to see our study published! Exciting science showing the utility of ctDNA monitoring after CH variant exclusion.
16 Mar 2023
Super exciting to work with @genentech on this creative analysis in @NatureMedicine of IMpower150 demonstrating the power of ctDNA monitoring to predict outcome on chemoIO:
nature.com/articles/s41591-0ā¦
5
23
2,124
Alexander Fine retweeted
16 Mar 2023
Super exciting to work with @genentech on this creative analysis in @NatureMedicine of IMpower150 demonstrating the power of ctDNA monitoring to predict outcome on chemoIO:
nature.com/articles/s41591-0ā¦
3
42
125
36,592
Alexander Fine retweeted
12 Dec 2022
"This is probably THE largest KRAS focused mutational database across human cancers I have seen" @Aiims1742
Incredible work @oncoOuLungCA @smruthy90 @VivekSubbiah @EthanSokol @geoff_oxnard @genentech @FoundationATCG
Read in #npjPrecisionOncology š§¬šÆ
nature.com/articles/s41698-0ā¦
16
34
Alexander Fine retweeted
12 Aug 2022
Thank you for involving me in this effort!
#ctDNA pre->on-tx change across multiple platforms & NSCLC #Immunotherapy studies correlate significantly with PFS, OS, tumor response.
@CancerResrch multi-institutional harmonization collab between #academia, #pharma, @FDAOncology
12 Aug 2022
Critical @CancerResrch collaborative effort across #Academia #pharma and @FDAOncology on #ctDNA dynamics for response monitoring during #immunotherapy just published in @JCOPO_ASCO.
Read here: trib.al/e6Fk2Na
#CTMoniTR #WhatFriendsDoes #ctDNAFriends #LCSM @hopkinskimmel
5
17
Alexander Fine retweeted
12 Aug 2022
ITāS HERE! Our #ctMoniTR Step 1 Manuscript was just published in @JCOPO_ASCO . Key takeaway: Our unique consortium demonstrated reductions in ctDNA are strongly associated with better clinical outcomes. What about the details? Aš§µ trib.al/e6Fk2Na
1
5
19
Alexander Fine retweeted
8 Aug 2022
In partnership with @flatironhealth, @genentech and a network of community oncology practices, we are excited to release new research on tumor profiling results from the ongoing Prospective Clinicogenomic (PCG) Study. More on this new data and the study: bit.ly/3d8pWsx
6
14
Alexander Fine retweeted
6 Jul 2022
Proud to share that we have now delivered 1 million reports, generated from our portfolio of CGP tests. Learn more about what this means for patients and the partners we serve in a blog from our CEO, Dr. Brian Alexander (@xelamb): bit.ly/3afPjru
5
11
Alexander Fine retweeted
30 Jun 2022
Itās out! We identify mutual exclusivity between microsatellite instability and HRD. BRCA1/2 mutations in MSI-H tumors are predominantly monoallelic passenger alterations which may not predict PARPi sensitivity. Rather patients may benefit from ICI. ascopubs.org/doi/abs/10.1200ā¦
8
71
181
Alexander Fine retweeted
9 Jun 2022
I am looking for someone to come work with me at @FoundationATCG! We are hiring a Scientist to join the Cancer Genomics Research team. We're a collaborative group investigating a 500,000 tumor sample dataset. Please share & reach out if interested! hcyc.fa.us2.oraclecloud.com/ā¦
4
7
Alexander Fine retweeted
9 Jun 2022
Come work with me!
9 Jun 2022
I am looking for someone to come work with me at @FoundationATCG! We are hiring a Scientist to join the Cancer Genomics Research team. We're a collaborative group investigating a 500,000 tumor sample dataset. Please share & reach out if interested! hcyc.fa.us2.oraclecloud.com/ā¦
4
1
Alexander Fine retweeted
5 Apr 2022
Foundation Medicine and Collaborators to Share Scientific Advances at AACR22 Reinforcing the Power of Genomic Testing in Precision Cancer Care | Foundation Medicine foundationmedicine.com/pressā¦
2
5
Alexander Fine retweeted
4 Apr 2022
Come work with me! You won't regret it!
4 Apr 2022
We are looking for a Scientist to join the Cancer Genomics Research team @FoundationATCG. We are a collaborative group and our 500,000 tumor sample dataset is sure to keep you curious! Please share/DM if interested! Happy to connect at AACR.
5
8