@AlexandreMayran profile picture
@alexandremayran.bsky.social @AlexandreMayran
Joined August 2009
  • Tweets 885
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Happy to present the final version of our Cadherin and gastruloid manuscript, online at @CellReports. in the thread below you'll find some of the key findings. cell.com/cell-reports/fullte… 1/12

Cadherins modulate the self-organizing potential of pseudo-embryos

Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven...

cell.com
@alexandremayran.bsky.social@AlexandreMayran
23 Nov 2023
Excited to share our effort to understand mechanisms underlying the potential for gastruloids self-organisation! #Gastruloids #InNumberWeTrust #EMT biorxiv.org/content/10.1101/… 1/11
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Can Aztekin@CanAztekin
Jun 11
Thrilled to receive the 2026 Schering Young Investigator Award! 🥳🤩 A huge thank you to all students, postdocs, collaborators, and mentors who have been part of this journey. Many thanks to the jury and the Schering Stiftung for this honor. bio.mpg.de/523934/can-azteki…

Can Aztekin erhält den Schering Young Investigator Award 2026  

bio.mpg.de
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Can Aztekin@CanAztekin
Apr 30
🔬 Diverse species. Stem cells. Highly international team. 🐸🐭 We’re looking for a Technical Assistant to join our stem cell–based research. Interested? Apply here 👉 jobs.tue.mpg.de/jobs/276
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Can Aztekin@CanAztekin
Apr 10
🚨Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @ScienceMagazine, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 science.org/doi/10.1126/scie… #EvoDevo

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus...

science.org
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Joshua Frenster@JoshiFrenster
Mar 24
The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @UniFreiburg this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. FrensterLab.com

Frenster Lab | Cell Competition Dynamics

We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells,...

frensterlab.com
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Flora Paldi@flora_paldi
Feb 23
A few days late in sharing, but but thrilled to share that my postdoctoral work on #3Dgenome and #CellularMemory is now published in @NatureGenet: nature.com/articles/s41588-0…

Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome...

Nature Genetics - Acute perturbation of histone acetylation induces changes in chromatin organization that are only partially reversed once the perturbation is removed and are associated with...

nature.com
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Happy to present the final version of our Cadherin and gastruloid manuscript, online at @CellReports. in the thread below you'll find some of the key findings. cell.com/cell-reports/fullte… 1/12

Cadherins modulate the self-organizing potential of pseudo-embryos

Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven...

cell.com
@alexandremayran.bsky.social@AlexandreMayran
23 Nov 2023
Excited to share our effort to understand mechanisms underlying the potential for gastruloids self-organisation! #Gastruloids #InNumberWeTrust #EMT biorxiv.org/content/10.1101/… 1/11
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Major thank to all the funding agencies, @snsf_ch, @nrp_79, @EPFL, @epflSV, @HFSP, and to the three reviewers for their constructive comments helping improve the manuscript. 11/12
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Stay tuned for other announcements to come soon @InstitutCochin 12/12
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Alfonso Martinez Arias@AMartinezArias
23 May 2025
In which we discuss the homologies between amphibian and mammalian #organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers sciencedirect.com/science/ar…
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Development@Dev_journal
21 May 2025
In preprints: exploring developmental robustness and timing with gastruloids Yonit Maroudas-Sacks, @Marc_Trani_ and @jvveenvliet @teamstembryo discuss three #preprints from the groups of @viktri08 @AlexandreMayran and @AMartinezArias: journals.biologists.com/dev/…
In preprints: a new preprint curation initiative from Development

ALT In preprints: a new preprint curation initiative from Development
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André Dias@_andre_Dias_
16 May 2025
We've just updated our manuscript to a more 'publishable' version! biorxiv.org/content/10.1101/… New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates
André Dias@_andre_Dias_
13 Jan 2025
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan. biorxiv.org/content/10.1101/…
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