Interested in cryoEM, cytoskeleton, and mechanosensation at the molecular level.
Joined October 2017
- Tweets 672
- Following 666
- Followers 1,511
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98 Photos and videos
Alushin_Lab retweeted
Jun 3
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
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Alushin_Lab retweeted
May 30
Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!
biorxiv.org/content/10.64898…
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Alushin_Lab retweeted
How do cells convert mechanical information into a molecular process? The @Alushin_Lab has captured the first snapshot of a mechanical signaling complex in action, findings in @Nature that have implications for disorders related to myosin dysfunction.
🔗: bit.ly/41Kshjw
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Apr 22
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature
nature.com/articles/s41586-0…
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Apr 22
After additional work, we believe that it is exclusively axial compression which produces supercoils. Compression can occur on a subset of filament segments even under conditions which globally produce tension, due to the stochastic mechanochemical cycles of uncoupled motors.
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Apr 22
We thank the reviewers for their insightful comments which clarified many additional aspects of the paper beyond this key point. Congrats to co-first authors Ayala Carl, Matt Reynolds @mattabolic_rate , and Xiaoyu Sun @XiaoyuSun_LIM !
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Mar 9
Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.
biorxiv.org/content/10.64898…
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Mar 2
Cytoskeleton enthusiasts: join us for the Cytoskeletal Motors GRC, July 12-17, 2026, in Portland Maine. Abstracts submitted by April 5 will be considered for short talks. Please apply!
bit.ly/4cWxvzj
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Alushin_Lab retweeted
31 Dec 2025
Scientists in the @Alushin_Lab figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview
🔗: bit.ly/3PKErmA
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Alushin_Lab retweeted
16 Dec 2025
DNA nanodevice for analysis of force-activated protein extension and interactions.
A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins.
nature.com/articles/s41565-0…
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Alushin_Lab retweeted
16 Dec 2025
🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici rdcu.be/eUPPl
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Alushin_Lab retweeted
9 Oct 2025
How do cells move, divide, and sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer and birth defects follow. @Alushin_Lab at @RockefellerUniv has developed new tools to probe this tiny, dynamic cell scaffolding.
rockefeller.edu/news/38446-h…
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Alushin_Lab retweeted
26 Aug 2025
nature.com/articles/s41567-0…
The latest research article from the Ti Lab is finally out today in Nature Physics.
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Alushin_Lab retweeted
20 Aug 2025
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
rockefeller.edu/facultysearc…
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Alushin_Lab retweeted
30 Jul 2025
Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab
wsj.com/politics/policy/trum… Trump Administration Puts New Chokehold on Billions in Health-Research
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Alushin_Lab retweeted
5 Jun 2025
Congratulations to Rockefeller’s #classof2025!!! #PhDone 🔬🎉🧬
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Alushin_Lab retweeted
31 Mar 2025
Keith Hamilton from the @Alushin_Lab at Rockefeller University gave a deep dive into the first step of any structural biological workflow: sample preparation. Through test cases he showed the balance of what is easily doable versus preserving biology.
alushinlab.rockefeller.edu/p…
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Alushin_Lab retweeted
27 Feb 2025
New study in @ScienceAdvances: the Alushin lab shows how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex. Dysregulated afadin expression has been associated with carcinogenesis and cancer metastasis.science.org/doi/10.1126/scia…
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Alushin_Lab retweeted
21 Feb 2025
science.org/doi/10.1126/scia… Just published! We uncovered a molecular machine that connects the cell's two major structural networks revealing how cells accomplish precise internal reorganization - a process disrupted in diseases ranging from cancer to multiple sclerosis.
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