Human biology matters. Scientists and AI need human data to understand health and disease. Crownlands is open sourcing Gateway 4M, the largest single-cell tissue dataset ever released from living humans, to advance research on brain aging and neurodegeneration.

A lot of people are already deploying AI into production codebases, but until now we didn’t really have a good eval for whether it writes code that is actually high-quality and maintainable. Pretty cool grading here:

Great write-up! What many in the space seem to over look is that there already exist data sets with *millions* of real-world human outcomes and increasing density of molecular readouts, ex @ourfuturehealth Never understood the reflex / imperative of collecting a niche low N dataset of similar depth when large population cohorts exist

I believe this next wave of Bio is going to be bigger than anyone can imagine. Multiple $10T companies. Maybe even a 100 Trillion dollar company.

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

Today, we're announcing @join_EF's Series D: $200M of fresh capital, at a unicorn valuation. We're in a golden age of entrepreneurship. More individuals than ever before are taking the leap, with the world's most transformative technology at their fingertips. For over a decade, we've backed extraordinary people without asking what idea they're working on. We call this Talent Investing; believing in someone from Day 1 and giving them the peer group, environment, and capital to find their life's work. And it works! Companies built through EF are now worth $16bn, up from $3bn at our last raise in 2021. Thank you to our investors for their continued belief, the EF team for bringing this vision to life, and the founders who rejected the status quo to build globally important companies with us. And, of course, a huge thank you to @matthewclifford, my exceptional cofounder.