World-class AI-powered protein design tools like BindCraft and BoltzGen, no-code UI, and instant GPUs—30% cheaper than AWS. Just pay for compute.
Joined April 2025
- Tweets 38
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7 Photos and videos
Ariax Bio retweeted
Mar 11
Thanks to @NikoMcCarty and the Asimov team for helping me get this out!
Hopefully an interesting view into where we are with AI antibody design today. Featuring @boltz_bio BindCraft @ai4s_protenix @AriaxBio @modal @tamarindbio @diffuse_bio @try_litefold @chaidiscovery @nablabio
Mar 11
A few years ago, designing an antibody on the computer was extremely difficult.
Today, there are several open-source tools which allow anyone to design antibodies from home.
Out today: A step-by-step guide to antibody design. By @btnaughton.
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Ariax Bio retweeted
Jan 5
What happened in the Nipah Protein Design Competition so far?
Plus: Prediction markets for protein design
TLDR:
• We hosted our third installment of the Protein Design Competition on @proteinbase, this time challenging participants to design a binder against the Nipah virus glycoprotein.
• The response was incredible: Over 10’000 designs were submitted, over 5 times the number of designs in the past 2 competitions combined, with more than 650 total participants.
• We’re currently testing all 1’200 selected designs, but, in the meantime, we’re taking a brief detour into what happened during the competition. Which model was the fan favorite? What did the top-ranking designs look like? And how can we select a better ranking metric for future competitions?
• Plus, we opened a prediction market on Manifold for this competition so you can bet on hit rates, best performing models, and more
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Curious how to run BoltzGen?
Our new tutorial walks through the complete workflow using our Adaptyv Nipah Competition submission as a real-world example. Target prep, hotspot selection, and launching parallel VHH/miniprotein campaigns.
Full tutorial: ariax.bio/resources/boltzgen…
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For alpha helical peptides, BindCraft is the SOTA model to beat. See our tutorial and commentary from BindCraft creator Martin Pacesa here:
ariax.bio/resources/bindcraf…
18 Nov 2025
BindCraft is generating high-affinity peptides from structure alone 🧬
MDM2: 47% hit rate (7/15 tested) with nM affinity. For WDR5, structural predictions were so precise they enabled "one-shot" stapling for a 6× potency boost (Kd 39nM).
No phage display. No alanine scanning.
GenAI is accelerating rational chemical design with less wet-lab screening.
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New GPUs on Ariax: Nvidia B300 RTX 6000 Pro now live.
B300 delivers a major performance jump for large/time-critical protein design campaigns. RTX 6000 Pro brings high VRAM for phenomenal value.
BindCraft already runs on B300; BoltzGen support soon.
ariax.bio/resources/new-gpus…
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Open source strikes back!
BoltzGen delivers Chai-2 level antibody design performance under an MIT license. Design nanobodies (VHH), cyclic-peptides, helicons, and miniproteins with an all-atom framework.
Run it now without limits on Ariax.
ariax.bio/resources/boltzgen…
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Ariax Bio retweeted
28 Oct 2025
1/2 We're now living the dream of (almost) fully programmable protein design. Learning about BindCraft is now essential 🧐
x.com/miangoar/status/196079…
Code to complex: AI-driven de novo binder design
pubmed.ncbi.nlm.nih.gov/4089…
Thanks to @MartinPacesa, Lennart N., and @AriaxBio :)
27 Aug 2025
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
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Ariax Bio retweeted
28 Oct 2025
We were so excited to meet and discuss with the protein community in Mexico, it was a great experience and we saw many great BindCraft designs generated in just one day session! Thanks to @aaronmring’s amazing @AriaxBio platform that made running it easier with so many teams
28 Oct 2025
1/2 🧵 We're learning how to use BindCraft at the Center for Genomic Sciences in Mexico 🇲🇽 BindCraft achieves an experimental success rate of 10–100%, compared to the 0.2% for traditional approaches 🔥 When people talk about drug design, they're actually referring to this.
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Waiting days for BindCraft results? Not anymore.
Turbo Mode splits your job across multiple GPUs for up to 8x faster completion. A typical 48-hour campaign now finishes in 6 hours: ariax.bio/resources/turbo-mo…
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👀
6 Oct 2025
I love these and also...they're ludicrous.
(BindCraft designed miniprotein for crystallizable core of NUTM1)
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Preparing PDB files for protein design usually means wrestling with PyMOL or ChimeraX. We're making it easier.
Watch us use our new Prep Inputs feature to go from PDB fetch → structure trimming → hotspot selection → launching a design job in a leisurely 75 seconds.
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Prep Inputs handles the tedious parts:
Load structures from RCSB or local files (PDB or CIF)
Trim chains & residues visually
Auto-detect binding interfaces
Export BindCraft-ready PDBs or start the job at Ariax
Free to use and everything runs locally in your browser.
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Ariax Bio retweeted
1 Oct 2025
pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.1101/…, we developed computational methods to rationally design pH-sensitive binders. 🧵
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Very exciting platform, extending BindCraft-style design to antibodies. Spinning it up for testing now...
24 Sep 2025
The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science.
Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving 4–22% success rates with efficient experimental validation.
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FreeBindCraft brings open-source protein design to everyone. By replacing PyRosetta with MIT/BSD-licensed alternatives, BindCraft has been freed from its licensing constraints. Available now on Ariax!
Read our announcement at ariax.bio/resources/freebind…
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Mosaic is an exciting new open-source protein binder design tool that uses back-propagation across additional models beyond AF2. It performs similarly to BindCraft, which is a big accomplishment- congrats to the team!
2 Sep 2025
Great blogpost by Nick Boyd and Sam Guns from Escalante Bio (posted on the other site!)
blog.escalante.bio/minibinde…
They introduce mosaic for binder design, and show some impressive results, with 7/10 and 8/10 binders working for two targets!
github.com/escalante-bio/mos…
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Ariax Bio retweeted
2 Sep 2025
Great blogpost by Nick Boyd and Sam Guns from Escalante Bio (posted on the other site!)
blog.escalante.bio/minibinde…
They introduce mosaic for binder design, and show some impressive results, with 7/10 and 8/10 binders working for two targets!
github.com/escalante-bio/mos…
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Congratulations, @MartinPacesa et al! BindCraft in Nature is a landmark for open protein design. It’s the reason we built Ariax: to make BindCraft and future open-source tools easy to use and broadly accessible. We're honored to build on the movement you created.
27 Aug 2025
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators.
nature.com/articles/s41586-0…
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