We focus on understanding the molecular mechanisms that regulate the function of the RNA binding protein TDP-43 in health and disease

Joined April 2019
21 Photos and videos
Ayala Lab retweeted
The @NIH announced cuts in grant funding, threatening vital research for neuromuscular diseases like ALS. While the policy is currently tied up in court, research funding remains at risk. @youralsnetwork and partners oppose these cuts and are committed to defending ALS research. Tell your member of Congress to protect lifesaving research! Take Action Now: alsnetwork.quorum.us/campaig…
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Ayala Lab retweeted
Yesterday, Target ALS founder Dan Doctoroff was celebrated with the naming of a street in his honor. From creating Hudson Yards to founding Target ALS, Dan has always led with vision, courage, and an unwavering belief in what’s possible.
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Ayala Lab retweeted
What a weekend — thank you, @PedalTheCause! Our hearts are full thanks to the thousands of riders, spinners, donors, sponsors, volunteers and others who gave their all to support @WashUMedicine cancer research at Siteman Cancer Center and Siteman Kids @STLChildrens Hospital. We can’t thank you enough! Together, we are building a world without cancer!
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Ayala Lab retweeted
15 Aug 2025
Robert F. Kennedy Jr announced that the US federal government is terminating US$500 million worth of grants for mRNA vaccine research. We must never, ever, forget that millions are alive today, or in better health, because of this life-saving technology. go.nature.com/3HDCS9n

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Ayala Lab retweeted
ALS research and care are at risk. Nationwide funding freezes and cuts threaten access to expert care and the breakthroughs people with ALS urgently need. We call on public leaders to protect the funding that fuels hope — for ALS and other neurodegenerative diseases. Lives depend on it. Read the ALS Network’s full statement here: alsnetwork.org/research-fund…
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Ayala Lab retweeted
Drawing the mind, one neuron at a time: A 2022 book walks readers through the life and work of Santiago Ramón y Cajal, the Spaniard whom many consider the founder of modern #neuroscience. Check out the #ScienceBooks Review on #BookLoversDay: scim.ag/41Z3pVU
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Ayala Lab retweeted
25 Jul 2025
In the latest issue! Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates dlvr.it/TM6tR5
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29 Jun 2025
Call your representatives to stop slashing the budget of federal funded research in the BBB. Their numbers can be found @5calls.org. #protect_research #science_saves_lives
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Ayala Lab retweeted
This #LouGehrigDay, we honor a legend whose life was forever changed by ALS—and whose name gives us strength to drive #ALSResearch to end it. Join us at the ballpark this week for #MLB games celebrating Lou's legacy and the ALS community. Get tickets: bit.ly/3Sa3SPx
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Ayala Lab retweeted
31 May 2025
Scientists uncover a combination of liquid-liquid phase separation and oxidation that may drive TDP-43 aggregation in ALS. @HymanLab @Alberti_Lab_TUD ow.ly/bBJ150W20Jk

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Ayala Lab retweeted
"We remember the joy that Pope Francis embodied and the humility with which he led." Today, Saint Louis University joins the world in mourning the loss of Pope Francis, the first Jesuit to serve as pontiff. Read a message by President Fred P. Pestello, Ph.D., as he reflects on the legacy of Pope Francis and his impact on the world. 📷 by Mazur/catholicnews.org.uk Read: loom.ly/IZdbAKk
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Ayala Lab retweeted
1/ 🌍 It’s finally out! Introducing the #AfricaniPSCInitiative, an open-access Somatic & Stem Cell Bank featuring rigorously profiled #iPSC lines from indigenous Africans. Huge thanks to @karchlab, who helped make this possible. See: biortc.com/african-ipsc-init…
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Ayala Lab retweeted
Secretary Kennedy seems to believe that vaccines against respiratory bugs that target a single antigen don't work. People who have studied and designed vaccines beg to differ. With multiple pending #Covid vaccines before #FDA, this may not bode well. statnews.com/2025/04/10/rfk-…
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Ayala Lab retweeted
There is phenomenal work being done on Alzheimer's and dementia at WashU Medicine Neurology and across #WashUMedicine, and we have gathered it all in one place for you. Take a minute to read through some of these groundbreaking stories: medicine.washu.edu/news/cate…
Can WashU Medicine stop Alzheimer’s before it starts? Could an "escape patient"— someone who was destined to develop Alzheimer’s but didn’t — hold the key to a breakthrough? Could our recent clinical trial pave the way for a drug that prevents Alzheimer’s? Learn more.
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Ayala Lab retweeted
Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB biorxiv.org/content/10.1101/… 🧵1/3
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Ayala Lab retweeted
On March 26, @SenatorBaldwin hosted a panel discussion about recent cuts to the @NIH and how they impact progress in developing vital treatments and cures for rare diseases. A special thank you to Jesse Ybarra, a veteran living with ALS, and his son, for advocating for essential funding and support on behalf of the ALS community. You can watch the entire discussion here: youtube.com/live/JofqSdWmhbM
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27 Mar 2025
RT @PeterHotez: NIH cutting coronavirus research oblivious to the realities: SARS-1, Southern China 2002 MERS-1, Arabian Peninsula 2012 SA…
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