Research group of @Ben_Leo_Parker @UniMelb as we lost access to previous account. We love metabolic proteomics and signal transduction.
Joined March 2024
- Tweets 72
- Following 199
- Followers 157
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9 Photos and videos
Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. nature.com/articles/s41467-0…
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Massive effort from @duttmri and thanks to @UniMelbCMR @MattWattUnimelb @garrondodd @GordonSLynch @WEHI_research and many others!
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Thanks for all the support!
Congrats to the CMR's @duttmri, @Ben_Leo_Parker and Team for their new Nature Comms paper "Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator"
@UniMelbMDHS @UniMelb
nature.com/articles/s41467-0…
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Protein:protein interactions are dynamic so how do we quantify and discover changes in native tissues? Our new study uses qXL-MS and PCP-MS to study dynamic remodeling of interactions following skeletal muscle insulin resistance. biorxiv.org/content/10.64898… #myotwitter #proteomics
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24 Dec 2024
An amazing opportunity with such a cool team!
24 Dec 2024
🚨 Join Our Team! 🚨
We’re on the hunt for a brilliant postdoctoral researcher with a passion for neuroscience or metabolic disease. This is your chance to work at the intersection of academia & industry, driving innovation in obesity & T2D research. 🌟
jobs.unimelb.edu.au/caw/en/j…
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20 Dec 2024
Thanks for the leadership @MattWattUnimelb! Couldn’t have done it without you.
19 Dec 2024
Thrilled that the metabolism theme in Dept of Anatomy & Physiology were awarded NHMRC and ARC grants in #obesity #MASLD, #fibrosis and #aging. Go @garrondodd @Ben_Leo_Parker @MagdaMontg64866 @MattWattUnimelb 🎉💯🙂 @UniMelbMDHS
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Benjamin Parker retweeted
7 Nov 2024
Abstract submissions are closing in a few weeks! Register now for the free WEHI Proteomics Symposium co-hosted by PMV.
eventbrite.com.au/e/proteomi…
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31 Oct 2024
UFMylation is a ubiquitin like modification of UFM1 applied to substrate lysine residues. <15 substrates have been identified (a nice summary: doi.org/10.1016/j.molcel.202…). RPL26 has been most extensively characterised and suggested to be the major substrate: doi.org/10.1073/pnas.1816202…
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31 Oct 2024
Why do we care? Because we have previously shown that UFC1 levels are negatively correlated with lean mass in various mouse strains, and knockdown of UFC1/UFMylation can increase muscle function. Maybe myosin UFMylation is a key link?
doi.org/10.7554/eLife.82951
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31 Oct 2024
A big thanks to @UniMelbMDHS and @CellSignal for supporting this research, and several collaborators @UniMelbCMR @JamesMc2327 @CraigAGoodman1 @OchDr @NgoShyuan and many others!
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31 Oct 2024
Check out our new #proteomic method to site-specifically quantify UFMylation! We applied the approach to look at human skeletal muscle biopsies from #ALS. A great collaboration with @CellSignal and many others...
A little summary below...
biorxiv.org/content/10.1101/…
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30 Oct 2024
Extremely proud of Kits PhD journey and amazing Oration. Thanks @MattWattUnimelb and @GordonSLynch for all the support throughout the years.
30 Oct 2024
Kit Ng presenting his final PhD oration on exercise phosphoproteomics and skeletal muscle at Dept of Anatomy and Physiology. Awesome to see the journey. @BenParkerLab @UniMelbMDHS
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Benjamin Parker retweeted
18 Oct 2024
Introducing our new study @ Tissue-PPT, an Extensive Atlas of Proteome and Phosphoproteome Turnover across mouse tissues and brain regions. biorxiv.org/content/10.1101/… @Yanshen73854711 @JunminPengLab @euforna #Proteomics #TeamMassSpec #Proteinturnover
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Benjamin Parker retweeted
14 Oct 2024
Registrations and abstracts are now open for the free WEHI Proteomics Symposium (Feb 6th 2025), co-hosted by PMV. Details below
eventbrite.com.au/e/proteomi…
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Benjamin Parker retweeted
9 Oct 2024
Congratulations to colleagues Gary Churchill (@jacksonlab) & Andrea Di Francesco (Calico) on this landmark publication. We were fortunate to phenotype these mice to extend our visual frailty index to genetically diverse mice (preprint on way). nature.com/articles/s41586-0…
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28 Sep 2024
A fantastic opportunity!
27 Sep 2024
Our lab is looking for a postdoc @uwgenome/@UW/@UWISCRM!
We tackle a wide range of biological Qs from cell-specific responses to perturbation to molecular consequences of aging.
We also work hard on new #TeamMassSpec methods to scale the # of proteomics samples we can analyze.
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