Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!

@Gandhar_Datar joined the lab when the world was shutting down, having just gotten started with guidance from @therealDrGundry and @BrunettiLab, who then moved on in their careers. Tough work in isolation until @RibackLab joined @bcmhouston, when informal chats got us thinking about the project in a whole new way. We considered how the aberrant function of NPM1c was related (or not) to its nucleolar WT function. A great collaboration grew, with Gandhar deeply learning both hematology and biophysics! Many ppl world-wide contributed and @sciencyelmira was the closer, getting the in vivo models working. Thanks to all, including the reviewers and editors for feedback.

Calorie restriction aerobic/resistance #exercise is the winning combo in older adults with #frailty & #obesity: it improves body composition & insulin secretion. CNTF & IGF-1 might play a role! Grateful to @ESPENorg & @EASDnews Rising Star grants clinicalnutritionjournal.com…

Excited for our session on critical trial appraisal here at #EHA2025 in Amber 7&8 - @Capt__Kirkwood on randomisation - @ComeBommier on surrogate endpoints - me on postprogression care & overall survival - Fabio Efficace on patient reported outcomes #lymsm

A/Prof @Capt__Kirkwood give us some great examples from within haematology of the importance of randomization & types of bias that can crop up in its absence (and occasionally in its presence!) #EHA2025 @young_eha

Before you go on Xmas holidays remember 👇👇👇 Deadline for abstract submission to join us at #EHAReCon2025 in Malaga on March 17-20 is January 8th !! I will be chairing the session on Transcripitional control with this fab lineup of speakers 🤩 @young_eha

1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! nature.com/articles/s41556-0…. 🧵 below:

Our team @SCICambridge is expanding and we have now a very exciting opening for a Laboratory Research Technician/Assistant!!! More positions to be announced very soon. Help us spread the word 👇👇🔬🔬 jobs.cam.ac.uk/job/47567/

Today, at TLH, we summarise a decade of hard work. We wish to thank all colleagues, patients and relatives, who helped us during this amazing journey. thelancet.com/journals/lanha…

"We are convinced that #academic CAR T-cell therapy will play an increasingly important role in cancer therapeutics... It would be unfair to leave our patients to their own devices when there is so much we can do for them" In Focus #CARtx @hospitalclinic thelancet.com/journals/lanha…

Lots of #MRD studies presented at #EHA2024 Many investigators consider MRD as a surrogate endpoint, although not validated in many indications. Please read/share this review. Might help understand concept and current evidence. Agree @VPrasadMDMPH ? ashpublications.org/blood/ar…

It really is so incredible! #palliativecare #bloodcancers #EHA2024

Just got a coffee at #EHA2024 (thanks @sanofi ) and I was told I was the first person to ask for a coffee in a reusable cup. So come on everyone, bring your own cups next year to reduce waste and create a more sustainable congress ! @young_eha @EHA_Hematology

An entire session dedicated to #palliativecare at #EHA2024. Proud of what we have achieved with the @young_eha committee! 🌱@EHA_Hematology