The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Chair, Dept of Mol Cell Biology at Baylor College of Medicine. Tweets my own.
Joined March 2012
- Tweets 831
- Following 546
- Followers 4,764
- Likes 3,322
172 Photos and videos
Jun 5
Two Presidents of @BCMhouston! Excited to welcome Jakub Tolar as our new President and CEO! He brings enormous energy and enthusiasm to take BCM into the next era, bringing deep experience leading a learning health system and his own interests in clinical translation of basic discoveries. Also grateful for the 16-year leadership of Paul E Klotman, who brought us through financial challenges, the pandemic, and a changing academic landscape with calm and humor. He modernized medical education, our infrastructure, and bolstered our finances; we grew and evolved. We are in a fantastic position for the future. Hope to be recruiting soon- watch this space!
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Apr 22
Amazing paper showing somatic mutations and massive clonal selection for lymphocytes that drive autoimmune disease.
Autoimmune diseases are varied and individually relatively uncommon but as a group highly prevalent. These cause lots of morbidity to very many people, with huge personal, societal, and economic impact. If these findings are extended to other autoimmune conditions, they will have huge implications for treatment.
Lots in this paper - somatic evolution, new tech, old theories, mutations in your favorite genes... The thread is a great TL;DR for the paper.
Go deep and read the cited 2007 Goodnow paper (post#6) - amazingly detailed and prescient- from ~20 years ago!
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
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Apr 3
Data on factors impacting time-to-acceptance could be crowd-sourced.
Major factors:
- time before first editor desk decision (varies a lot by editor and journal)
- review time (huge variation; also heavily influenced by the editors)
- editor decision time after reviews come in (can be longer than one would think)
– revision time (authors chasing very time-consuming experiments for the win; heavily influenced by (lack of) editor guidance, but also topic, model system...)
- second round (all same variables)
- possible appeal time (appeals are high at top journals and take even more time and can add to total time)
Journals track all this data. Authors should have it too.
Decent crowd-sourced data could be in ~real-time, and would help authors make informed decisions. I think many ppl would contribute data from their experience.
Monthly median Received to Accepted time (days) at Nature Genetics
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Apr 2
Great visit with an inspiring group of hematologists! 🙏
👉👉👉Wonderful Visiting Professor Day today with Dr Peggy Goodell .@Goodell_Lab 🙏 for spending time with us at @UTMDAnderson Hematology Grand Rounds hosted by Dr @garciamanero & @doctorpemm | #leusm #endcancer | @sanamloghavi @DrKTakahashi @NitinJainMD @Daver_Leukemia |
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Mar 31
Exciting new study demonstrating durable DNA methylation reprogramming (editing) in hematopoiesis!
Mar 30
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: biorxiv.org/content/10.64898…
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Peggy Goodell retweeted
Mar 30
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety exphem.org/article/S0301-472…
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Mar 18
Remarkable new study showing that many individuals with genetic variants that disrupt the function of myostatin (a protein that normally inhibits muscle growth) have ⬆️muscle mass,⬇️ body fat, and ⬆️strength.
Increased muscle mass is clinically desirable for #healthyaging and for countering muscle loss in various contexts (including use of #GLP1 agonists). Below, MRI images of a subject with above-average muscle mass (left) and average muscle mass (right) from the study. Congrats @davidjglassMD and colleagues! Link ⬇️
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Mar 18
It’s also a testament to the incredible societal value of these huge biobanks, the careful genotyping, thoughtful phenotyping, and mechanisms to make these available for analysis. THANK YOU to everyone who participates as a subject, to all the researchers who have worked so hard on these incredibly valuable resources, and to the funding bodies with foresight to invest in these. UKB and similar are truly transformative IMO.
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Mar 18
An interesting question not addressed is the lifestyle differences of people with inactivating myostatin variants. You might guess that people with more muscle will excel in activities where those traits are valuable (e.g., athletics or certain jobs). Those activities might be self-reinforcing, further enhancing muscle growth and amplifying the apparent genetic effect over time. Lots more to learn, but a great investigation that will move the field forward. #aging #muscle #health
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Mar 12
Important work w real translational potential for cancer patients. Built on foundational science developed over years. Congrats to all!
Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432
nature.com/articles/s41588-0…
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Peggy Goodell retweeted
Somatic genomics as a discovery engine for biomedicine - a Perspective in Cell
sciencedirect.com/science/ar…
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Feb 24
Amazing new findings on clonal evolution by @jrblundell and team. #dnamethylation barcode for clonal collapse.
Feb 24
The methylation patterns at this locus are highly diverse, but once established they are faithfully inherited through cell division. Every clone has its own epigenetic signature. In polyclonal tissue you see a rich, stable rainbow of diversity. When a clone expands, it takes over
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Peggy Goodell retweeted
📢 Our review on clonal hematopoiesis evolutionary dynamics using mathematics is now available online @NatureGenet Check it out! #CHIPsm
Feb 16
Modeling the evolutionary dynamics of clonal hematopoiesis -- @S_Marzban et al, Nature Genetics
rdcu.be/e4cP1
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Peggy Goodell retweeted
Feb 5
#FromSketchToCover ✨
For the cover of @MolSystBiol Molecular Systems Biology (Vol. 19, Issue 3), we adapted Hope II by Gustav Klimt into a scientific visual language.
The goal: preserve the themes of pregnancy, vulnerability, and protection, while translating them into a story about placental immune modulation by Group B Streptococcus.
Art history meets molecular systems biology!
🔗 link.springer.com/article/10…
#SciArt #ScientificIllustration #SciComm #JournalCover #DrawImpacts
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Feb 2
Great study on resilience and survival of stem cells in aging muscle! #aging
Excited to share a recent publication from the lab. Daniel Benjamin & Jengmin Kang led the study of the allocation of resources to survival over reproduction in stem cells during aging. #EvolutionaryTradeOffs #SurvivorshipBias
science.org/doi/10.1126/scie…
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Feb 1
Excited to be speaking at the upcoming @KeystoneSymp on 🩸Hematopoiesis 🩸Feb 23-26 organized by @BeaudinLab and Esther Obeng. Poster abstracts due Feb 3. All-star cast w/ great science and networking!
Doubleheader 2-for-1 with Myeloid Cells mtg!
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