Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!
(1/10) How do diverse leukemia mutations converge on the same molecular program?
In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).đź«§
7
16
87
10,424
Riback Lab - Cellular Physical Chemistry Group retweeted
Excited to share @RibackLab’s first paper in @CellCellPress. Together with @Goodell_Lab, we show that diverse leukemia mutations converge on a biophysically indistinguishable nuclear condensate—the C-body. Huge thanks to @Gandhar_Datar, @sciencyelmira, and co-authors!
(1/10) How do diverse leukemia mutations converge on the same molecular program?
In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).đź«§
1
4
18
2,102
Riback Lab - Cellular Physical Chemistry Group retweeted
(1/10) How do diverse leukemia mutations converge on the same molecular program?
In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).đź«§
3
27
65
23,777
Riback Lab - Cellular Physical Chemistry Group retweeted
In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Happy TWO YEAR anniversary to the lab 🎉🎉 thanks to our fearless team leader @BoeynaemsSteven & friends of the lab for celebrating with us a few weeks ago!! @JLeeLab & @RibackLab
1
4
827
Riback Lab - Cellular Physical Chemistry Group retweeted
Joint lab meeting with @RibackLab & @JLeeLab was such a blast and huge success!! Looking forward to many more condensate meetings 🎉🎉@BoeynaemsSteven
1
4
15
3,019
Riback Lab - Cellular Physical Chemistry Group retweeted
New @RibackLab swag is here to keep everyone caffeinated and hydrated in the Houston heat! Disclaimer: No microscopes were harmed in the making of this photo.
1
15
1,033
Riback Lab - Cellular Physical Chemistry Group retweeted
Congrats to @RibackLab members @Gandhar_Datar (co-advised with @Goodell_Lab) for winning the 3rd place talk award on AML condensate form and function and Kris for her @VisiTech_UK #iSIM microscopy image of nucleoli being chosen for the MCB retreat cover!
It’s the end of the day at the MCB retreat and we’re celebrating all the poster and talk awardees! Amazing job by the organizers and participants! Plus we got to see some animals at the Houston zoo :)
@BCMFromtheLabs@bcmhouston@Goodell_Lab
Congrats to @Gandhar_Datar , co-mentored student with @Goodell_Lab , for his awe-inspiring talk demonstrating that NPM1 mutant driven nuclear phase separation sustains HOX in models of leukemia, incomparably combining both rigorous cancer and biophysics research #BPS2023
Additionally, Archish concluded #BPS2023 with his poster with some budding quantitative microscopy methods and the representing @RibackLab took a selfie to demark the occasion!
Congrats Kris on her #BPS2023 talk today on our new method to measure condensate liquid structure in live cells! Great job co-chair of the session, @Gandhar_Datar !
1
13
1,371
Riback Lab - Cellular Physical Chemistry Group retweeted
Hey everyone, the @RibackLab is at #BPS2023! Unfortunately, I was not able to attend the @BiophysicalSoc Annual Meeting this year as planned due to getting COVID. I'll miss seeing you all and learning about the latest research! 1/5
The iSIM impresses us with super-resolution (without decon!) without sacrificing speed or field of view. Here are images from @Gandhar_Datar (phase separation preacher to the @Goodell_Lab) and amazing roton @CalebRosenblad! Both taken with help of microscope master Archish! 2/3
We are indebted to @JLeeLab for his critical role in this process from brainstorming to testing! Additionally to @CPRITTexas, without which the purchase of this jaw-dropping microscope would not be possible! 3/3