🔥💉 High-dose IV vitamin C for severe burns?
Our large intern. RCT says:
❌ no survival benefit
❌ no shorter hospital stay
❌ no less organ failure
📉 Another null result. Physiology ≠ clinical benefit.
🧵 Read the thread & trial 👇
ja.ma/49RpUzX#CCR26#VitaminC
Day1 at #CCR26#LOGICALtrial: conservative O₂ after cardiac arrest
#MARCHtrial: carbocisteine /or HTS for airway secretions
#VICTORYtrial: high-dose IV vitaminC in burns
None improved outcomes; MARCH and VICTORY➡️possible harm!
✅#TeleRehabTrial: in AHRF pts, ⬆️QoL ⬇️mortality
➡️ Severe burns trigger profound inflammation, capillary leak & organ dysfunction
➡️ Could high-dose vitamin C modify this?
➡️ Join us at #CCR26 for the VICTORY trial results, presented by @CStoppe
Full, free livestream — but it’s better in person
criticalcarereviews.com/meet…
🕒 48h is the sweet spot.
…- More isn't better!
👉🏽 another reminder in critical care: knowing when to stop is as important as knowing when to start!
#AKi#health#protein
👉 Nutrition in the ICU is not a checkbox — it is a dynamic, physiology-driven intervent. that requires contin. reassessment. Further key messages @ISICEM :
🔹 Micronutrients: more ≠ better
🔹 Protein: we underdeliver, but pls. stay <1.3g!
🔹 Timing matters
🔹 Calories = a drug
Day -1 of #ISICEM2026 is off to a great start with the pre-courses! Deep dives into measuring metabolic tolerance & GI function to better guide enteral & parenteral feeding. Great discussions on optimizing icu nutrition 🏥💉📊 #ICU#CriticalCare#Nutrition
Is nutrition just "supportive care" for the injured brain? 🧠 We argue it's a modifiable therapy that can influence recovery.
🥄 Why early low-dose EN is preferred
⚡ The role of ketogenic diets & lactate
📊 Urgent need for trials rdcu.be/e7NLv#NeuroICU#MedTwitter
As 2025 comes to a close, the ERAS Cardiac Society thanks the global community advancing enhanced recovery after cardiac surgery.
Grounded in evidence and collaboration, we remain focused on improving patient recovery and expanding education and implementation in 2026.
On the 8th day of Christmas, my true love gave to me…
🎄 8 ventilators humming
🎅 7 nurses charting
🫁 6 lungs oxygenating
💉 5 infusions avoided
📊 4 outcomes hierarchised
📞 3-month follow-up
🌬️ 2 sedation strategies
🐦 And a partridge asleep in a pear tree
#CCR26
🎄 On the sixth day of Christmas my true love gave to me
🍊 five juicy oranges
🍏 four green apples
🐦 three burnt partridges
🏆 And finally a vitamin C trial ending in VICTORY....
#CCR26criticalcarereviews.com/meet…
For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality.
ja.ma/48uJPnZ
Original Article: A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia (SONIA trial) nej.md/47glh02
Editorial: Glucocorticoids for Pneumonia in Africa — Old Therapy, New Context nej.md/4qgjdxH#Pulmonology#CriticalCare
ALT A graph of the cumulative risk of death from any cause.
Presented at CCR Down Under 2025:
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB@CritCareReviews
ALT CCR Down Under 2025
Original Article | Dec. 9, 2025 | NEJM.org
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults
Figure 1. In-Hospital Death, According to Trial Group.
The NEJM identity sits at the bottom.
Today's Paper of the Day is:
Pulmonary artery catheterisation
criticalcarereviews.com/late…
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
NATA26 I 29 Apr-02 May I Bilbao🇪🇸
Abstract submission for #NATA26 is open — and Bilbao is calling.
Whether you’re advancing PBM, redefining haemostasis & thrombosis practice, or improving transfusion safety, we want to hear from you.
Submit here 👉 nataonline.com/annual-sympos…
🚨Does parenteral Omega-3 fatty acid administration increase the risk of... sciencedirect.com/science/ar… While the risk is established for long-term oral use, short-term admin of intravenous fish oil lipid emulsions (FO-ILEs) is unlikely to induce AF. A must read 👇 #ICU#Fishoil