Structural basis of human Nav1.5 gating mechanisms | PNAS pnas.org/doi/10.1073/pnas.24…

What the industry is hiding about nicotine pouches: ☠️ Addictive: designed to hook you fast 🧪 Toxic: unregulated levels of nicotine ❤️ Increased risk of cardiovascular disease 🧠 Damages brain development No smoke. No smell. No warning. Around 160 countries have NO specific regulations for nicotine pouches. The industry is exploiting every gap. It's time to expose them. #TobaccoExposed

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature nature.com/articles/s41586-0…

A new study from @Heissler_Lab titled MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypes published in Cellular and Molecular Life Sciences link.springer.com/article/10… @OhioStateDHLRI @OhioStateMed

Exciting study from Deschenes and Chinthalapudi @CellAdhesion labs. Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5. nature.com/articles/s41467-0… @NatureComms @OSUWexMed @OhioStateDHLRI @OhioStateMed

Basic Experimental Studies in Humans (BESH) Will No Longer Be Considered Clinical Trials by the NIH grants.nih.gov/grants/guide/…

A new collaborative paper from @Heissler_Lab and @CellAdhesion lab. Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation rupress.org/jcb/article/225/… @OhioStateDHLRI @OSUWexMed

Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab wsj.com/politics/policy/trum… Trump Administration Puts New Chokehold on Billions in Health-Research

We are walking the Ullswater Way with @OscarsCharity in May. Learn more and donate here: justgiving.com/team/thalia #braintumours #childhoodcancer #cancer

NIH has stopped considering new grant applications, delaying decisions about how to spend millions of dollars. The freeze occurred because the Trump administration has blocked the NIH… npr.org/sections/shots-healt…

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.

I’m looking for a motivated postdoc to join my lab with a structural biology background. Reach out to me if you are interested in the structure-function studies of actin cytoskeleton and membrane repair processes.

@CellAdhesion @Heissler_Lab report the structure of dysferlin, offering insights into its molecular mechanisms and how mutations impair its function #dysferlin #membrane_repair nature.com/articles/s41467-0…

Our latest research on dysferlin has just been published. @Heissler_Lab. nature.com/articles/s41467-0… #membrane_repair #dysferlin #dysferlinopathy

Our work on membrane repair protein dysferlin is published in Nature Communications. Very proud of the team. rdcu.be/dZuag

Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P g... sciencedirect.com/science/ar… Our work on cardiac actin mutants A331P and M305L is now published. Great collaboration with @Heissler_Lab @SPOREMOHAN labs.

Another beautiful collaboration with @Heissler_Lab and @CellAdhesion Structure and analysis of HCM causing actin mutations ACTC1 M305L and A331P sciencedirect.com/science/ar…

Structural insights into the regulation of RyR1 by S100A1 | PNAS pnas.org/doi/10.1073/pnas.24…

Excited to share our latest preprint on the Mical1 activation mechanism. Many thanks to Petra Janning, Ingrid Vetter, and especially @GoodyRoger for their excellent collaboration. @mpimoph biorxiv.org/content/10.1101/…