Understanding the role and regulation of all the post-translational modifications on molecular chaperones. See chaperonecode.com
Joined October 2020
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15 Nov 2021
A reminder to join the seminar by Professor Kalodimos on “Atomic View of Molecular Chaperones in Complex with Unfolded Clients” tomorrow (11/16) at 11am EST. To register please go to chaperonecode.com/registrati…. #hsp90 #chaperonecode.
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1 Nov 2021
We are excited to announce a seminar by Professor Kalodimos’s “Atomic View of Molecular Chaperones in Complex with Unfolded Clients” on 11/16 at 11am EST. To register please go to chaperonecode.com/registrati…. #hsp90 #chaperonecode.
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The Chaperone Code retweeted
24 Oct 2021
There ist still time to sign up for our upcoming online symposium, starting Oct 27, registration is free!
We have great speakers and chairs including @TrumanLab @shouval @lundpa @MedMol @gclab1 John Lis @HawleLab @GestwickiLab @sistonheat and many more: cellstressresponses.org/upco…
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1 Oct 2021
1/ Our PI of the week is Dr. Dalia Barsyte-Lovejoy (@BarsyteDalia). After obtaining a PhD in molecular cell biology and toxicology from the @OfficialUoM, she studied kinase-transcription factor signaling during her postdoctoral training at @OICR_news.
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1 Oct 2021
3/ She appeared on our #chaperonecode radar after publishing an outstanding article in @NatureComms on monomethylation of #Hsp70 by PRMT7. Inhibition of Hsp70 methylation via the small molecule SGC3027 leads to a compromised cellular stress response: ncbi.nlm.nih.gov/pmc/article…
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1 Oct 2021
4/ Dr. Dalia Barsyte-Lovejoy continues to push the boundaries of chemical biology and proteomics to understand the global role of protein methylation, publishing an excellent review in @NatRevDrugDisc on this topic: nature.com/articles/s41573-0… #methylation #chaperonecode #hsp70
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24 Sep 2021
1/ Our PI of the week is Dr. Seema Mattoo (@MattooLab), Associate Professor at Purdue University in Indiana (@LifeAtPurdue). After obtaining a PhD in Microbiology & Immunology @UCLA, she pursued a post-doctoral fellow @ucsd and went on to work as a research scientist at HHMI.
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24 Sep 2021
5/ Of course, we are especially excited by her studies on PTMs on chaperones! Her 2015 paper in @jbiolchem demonstrated the ability of HYPE, a human Fic protein to localize to the ER and adenylate BiP, the ER-resident Hsp70: sciencedirect.com/science/ar…
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24 Sep 2021
6/ Dr. Mattoo has continued to be one of our favorite chaperone code researchers and her most recent work shows that the HYPE-BiP interaction maintains ER homeostasis. link.springer.com/article/10… We look forward to seeing what will come next for the Mattoo Lab!
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17 Sep 2021
1/ Our PI of the week is Dr. Stephanie Diezmann (@diezmannlab). She has published over 20 high profile papers and her work has been cited nearly 1500 times! Dr. Diezmann obtained a degree in Biology from @HumboldtUni and a PhD from @DukeU.
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17 Sep 2021
4/ Although previous studies have observed connections between #Hsp70 phosphorylation candida pathogenesis (sciencedirect.com/science/ar…), the role of Hsp90 PTMs in candida has remained unclear.
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17 Sep 2021
5/ Dr. Diezmann’s recent excellent studies cement the #chaperoneode as key for candida virulence. Please see: biorxiv.org/content/10.1101/… and ncbi.nlm.nih.gov/pmc/article…
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13 Sep 2021
Our Chaperone Code Club meetings resume with a seminar by Professor Laurence Pearl’s @laurencepearl “Chaperone Targeted Degradation of Hsp90 Client Proteins” on 09/15 at 11am EST. To register please go chaperonecode.com/registrati…. #hsp90 #chaperonecode
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10 Sep 2021
1/ Our PI of the week is Dr. Mehdi Mollapour (@MedMol), Professor and Vice Chair for Translational Research at SUNY Upstate Medical University. Having published more than 80-scientific papers, reviews and book chapters, he has received a number of awards and recognitions
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10 Sep 2021
5/ Only a few weeks old, truly beautiful work demonstrating a connection between metabolism and the FLCN oncoprotein in @NatureSMB: nature.com/articles/s41594-0…
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10 Sep 2021
6/ Finally to get a real insight into Dr. Mollapour’s thoughts on the Hsp90 chaperone code, please check out this review in @jbiolchem: pubmed.ncbi.nlm.nih.gov/3252…
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