Registration is now open for our Workshop. Please apply here: sites.google.com/view/crete-…. Deadline November 30th.

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @_TheTransmitter thetransmitter.org/drug-deve…

Some great papers in here! Good primers on this emerging area

New essay in @CurrentBiology special brain-body issue!🧠↔️🫀 Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino J. Oliveira-Maia showing @ChampalimaudF discovery science↔️ clinic at its best. cell.com/current-biology/ful…

The ancient dialogue between brain and body sciencedirect.com/science/ar…

100% agree with @DavidAMarkowitz 's vision. But I would be much more specific in the lesson learned from the fly connectome revolution: we need to generate a *dense axonal projectome of the primate brain* NOW. This will give us the key sine qua non puzzle pieces to figure out primate intelligence, and is a project that doesn't rely on any vagaries. Money in = Knowledge that will utterly transform our understanding of intelligence out. NIH is funding smaller scale efforts to reach this milestone, but private philanthropy could leapfrog us to the revolution much faster. Without this map, we students of primate intelligence are like wanderers trying to make sense of the world with blindfolds on. @rclayreid @SebastianSeung

Fantastic time with students and postdocs of the @Cajal_Training #Brain Prize Motor School, @LoraBSweeney @GattoGraziana recording and modeling motor activity from locusts, frogs, mice, zebrafish... what a fun crew !

Time for science! This is a paper I loved for a couple reasons. 1) It gives a clear explanation for how noisy and antagonist neuropeptide signals ultimately determine satiety. 2) I think the tools and approach might be the future of systems neuro nature.com/articles/s41586-0…

Thank you to everyone who joined us this week @HHMIJanelia for a unique and multidisciplinary meeting on the sensory biology of ingestion!

I'll be talking with Mala Murthy and Sebastian Seung (@SebastianSeung) next week about flywire. You can register below. It's 30 min discussion followed by Q&A. Mala and Sebastian are brilliant and I hope you tune in. I am there just to ask questions :) workcast.com/register?cpak=3…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

SfN has too many best moments: Cori and Gerry received Gruber prize. “Each circuit is many circuits” “These colleagues also taught me about leadership, which is important for science”. ❤️❤️❤️❤️❤️@betenoire1

The 2024 #NobelPrize in Physiology or Medicine focuses on the discovery of a vital regulatory mechanism used in cells to control gene activity. Genetic information flows from DNA to messenger RNA (mRNA), via a process called transcription, and then on to the cellular machinery for protein production. There, mRNAs are translated so that proteins are made according to the genetic instructions stored in DNA. Since the mid-20th century, several of the most fundamental scientific discoveries have explained how these processes work. In 1993, this year's Nobel Prize laureates published unexpected findings describing a new level of gene regulation, which turned out to be highly significant and conserved throughout evolution. They discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Read more: bit.ly/4dlPE6f

Finally the official arrival of the SEZ into the connectome world with some additional fly neurons around it. Congratulation to everybody who participated. This has been a lot of fun. And so much more to come! #collaborationsmovescienceforward

Its finally out @Nature ! So grateful to have been part of this beautiful work and the dream team that made it happen! nature.com/articles/s41586-0… @NehaSapakal @NinoMancini_

📢 Applications are open! Join colleagues @HHMIJanelia to explore analysis and modeling of #connectomes to derive insights and solve biological problems. Learn more apply by Dec. 3 @ janelia.news/NCR25 @HHMINews @srinituraga @GjorJulijana #computationalbiology #computationalneuroscience #theoreticalneuroscience #connectomics

Sex or survival—what’s more important? Excited to share our @Nature paper on how flies resolve this conflict. We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating. nature.com/articles/s41586-0…