Student-run twitter account for the Chenoweth Lab at University of Pennsylvannia. Chemical Tools, Fluorophores, Nucleic Acid Binding Molecules, Collagen.
Yesterday I successfully defended my PhD @PennChemistry. Eternally grateful for the people who made these last 5 years a little easier, many of whom tuned in both virtually and IRL. I dreamed of this day so many times, never knowing how full my heart would feel.
ALT A lecture hall with people looking at a slide entitled "The Art of Chemistry: Tools for Chemical Biology and Conservation Science."
ALT A woman in a white shirt and blue pants stands and smiles, holding a mug that says "Dr. Rachel Lackner"
Congratulations to Matthew Good, PhD (@buenoscience) on his promotion to Associate Professor of Cell and Developmental Biology with tenure, an amazing achievement and milestone in his academic career!
Today was my last lab day before I move to NYC. I’ll be back to defend my thesis but until then I’ll miss my friends in the @DMChenowethLab and in @PennChemistry. I won’t miss the vagelos mice tho….
Check out the latest paper from the group! In collaboration with @lab_zhang, we developed an assay to study the "linkerology" of chemical dimerizers and applied a new tool to control phase separation.
If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized the linker for our TMP-Halo system for fast dimerization and applied it to control phase separation in cells. chemistry-europe.onlinelibra…
If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized the linker for our TMP-Halo system for fast dimerization and applied it to control phase separation in cells. chemistry-europe.onlinelibra…
Thrilled to share this work! We engineered a heme enzyme to activate diazirines, giving us access to donor-subsitituted carbenes in biocatalysis. Many thanks to @francesarnold and our collaborators Emma Danelius and @gonenlab.
doi.org/10.26434/chemrxiv-20…
Congratulations to Sam, @MicelleYoucelle, and Pengfei on their recent paper “Rules for Aza-Glycine Incorporation in Collagen Peptides” @ChemicalScience Also, we love Sam’s clever homage to The Price is Right in the outside cover art! pubs.rsc.org/en/content/arti…
Big congratulations to @danielwuhoo as he passed his dissertation defense and will be an alumnus from @PennChemistry! Dr. Daniel Wu will be joining @GSKUS as an Investigator in Chem Bio. We’re all excited for you and your future endeavors! 👏🙌
Hello! Rising third year @PennChemistry in the @DMChenowethLab here. I synthesize photoconvertible fluorescent molecules for spatiotemporal imaging and tracking of cells and cellular cargo. I’m an aspiring Chemical Biology P.I. and entrepreneur. #BlackinChem#BlackinChemRollCall
ALT Can't forget about my always supportive and empowering mother!
Rules for the Design of Aza-Glycine Stabilized Triple-Helical Collagen Peptides - A tour de force effort synthesizing ~46 peptides with 2 high res collagen xstal structures to complete the design rules for azGly incorporation by Sam Melton and colleagues pubs.rsc.org/en/content/arti…
Your synthesis of that many azGly containing collagen peptides better be pretty good if you’re making that many! See our optimized SPPS methods (link here) pubs.acs.org/doi/abs/10.1021…
.@angew_chem the Chemistry field will remember how you handled this. You published a paper that literally had “diversity of workforce” labeled as a negative influence on our field. This is not a moment to respond with the equivalent of “oops, we need to fix some typos.”
This paper contains opinions that don't reflect our values and has been removed. It wasn't the final version and is pending further editing and final review. Something went very wrong here and we're committed to do better. This isn't who we are and action will be taken.
Congrats to group alumnus Yang Hai @yanghaiBioChem - our 2016 paper describing the crystal structure of HDAC6 was highlighted as one of the Greatest Hits in the past five years of @nchembio! See "Best Partnership": nature.com/articles/s41589-0…
Have you read 'Rosetta custom score functions accurately predict ΔΔG of mutations at protein–protein interfaces using machine learning'?
It's the latest Comm from John J. Ferrie & E. James Petersson et al. @PennChemistry
👉🔗 ow.ly/GINV50zSmID