Joined June 2014
- Tweets 91
- Following 11
- Followers 553
- Likes 9
6 Photos and videos
26 Nov 2024
SIMBA, a novel quantitative intracellular peptide binding assay, is now on BioRxiv. It excels at saturation mutagenesis studies to define SLiM-binding determinants. This collaboration with the Pryciak group at UMass is the first of many, so keep a look out biorxiv.org/content/10.1101/…
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26 Nov 2024
Congratulations to @IfigeniaT42 and Iza on the publication of CompariPSSM - a PSSM–PSSM comparison tool for motif-binding determinant analysis. This part of Ifigenia's her recently completed PhD work and her first first author paper. Check it out here: academic.oup.com/bioinformat…
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12 Sep 2024
Have you ever wondered how many of the human SLiMs are required for cell viability? We mutated them all to find out in another extremely fun collaboration with the @NilssonLabCph group. The results are now on bioRxiv biorxiv.org/content/10.1101/…. Check it out!
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Short Linear Motif team retweeted
12 Sep 2024
Great collaboration with the @DaveyLab on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore!
A proteome-wide dependency map of protein interaction motifs biorxiv.org/content/10.1101/…
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6 Sep 2024
Excited to present a new docking motif for IKK (Inhibitor of κB (IκB) kinase)! A great collaboration with the Zanier lab at the ESBS showed a YDDΦxΦ motif in IκBα, IκBβ and p100 recruits IKK.
nature.com/articles/s41467-0…
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30 Aug 2024
Hazem's FaSTPACE paper is out, a novel tool for rapid peptide alignment and motif extraction! It's fast enough to tackle 1000s of peptides - just what's needed to tackle the recent explosion in high-throughput peptide discovery methods. Read here: academic.oup.com/nargab/arti…
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16 Jul 2024
Our new paper with the @Ivarssonlab &
@NilssonLabCph teams
characterising mutations in intrinsically disordered regions on a proteome-wide scale! We show numerous examples of disease-causing SNVs making and breaking SLiMs in work driven by Johanna Kliche. embopress.org/doi/full/10.10…
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24 Jun 2024
Our work on protein/phosphorylation abundance changes through the cell cycle is on bioRxiv. Very much an ICR Division of Cancer Biology project (Thanks to @jc4_jyoti @MansfeldLab @PinesLab teams). All pushed to completion by Camilla, Ifigenia and Theo. tinyurl.com/ccprofiles
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24 Jun 2024
There's an associated database to make it easier to explore the data. Check it out here slim.icr.ac.uk/cell_cycle/
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Short Linear Motif team retweeted
8 Nov 2023
Cool work from @duxin_lab on Pol Kappa. Happy that my lab together with @DaveyLab could contribute with base editing screening in cells.
Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis biorxiv.org/content/10.1101/…
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23 Oct 2023
We have an open PhD position applying mass spectrometry-based approaches to peptide interactomics for motif discovery. It's an exciting interdisciplinary project with the Choudhary lab for someone with a strong computational background. Details here: icr.ac.uk/studying-and-train…
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19 Sep 2023
Latest screen exploring how #disease-associated #SNVs in IDRs affect SLiM-based #protein-protein #interactions is now up on bioRxiv. Another fun collaboration with the @Ivarssonlab/@NilssonLabCph labs driven by the amazing team of Johanna and Leandro. disq.us/t/4j32bsx
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5 Sep 2023
The servers are all back online after their little summer holiday. Everything has been upgraded and there may be a few issues so let us know if you see anything odd.
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18 Aug 2023
Our resources (ProViz, PSSMSearch, SLiMSearch, xProtCAS, etc) will be down for a couple of days for updates to the server. Sorry if anyone is in need of some summer motif hunting. But hopefully most of you are on holidays.
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Short Linear Motif team retweeted
6 Jul 2023
Minimum Information About Disorder Experiments (MIADE) guidelines provide community recommendations on the minimum information that should be reported with experiments that structurally characterize intrinsically disordered proteins or regions.
@DaveyLab
nature.com/articles/s41592-0…
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Short Linear Motif team retweeted
4 Jul 2023
Time to get the disordered protein field a bit more ordered! We propose guidelines on how to describe IDP experiments to better serve experimental researchers, computational biologists, and database/method developers. This was a fun community wide effort led by @DaveyLab
A third of all known proteins are either completely or partially unstructured.
EMBL scientists contributed to MIADE, a new set of guidelines that will help researchers share data on such proteins in a more useful way & enable machine learning analyses.
embl.org/news/science/bringi…
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3 Jul 2023
The MIADE paper defining minimum information guidelines for the structural IDP field is out today in @naturemethods. I'm so thankful to the MIADE team, @_BalintMeszaros, Kim, @NPalopoli, Fede, Andras and Eduardo, for helping push the project to completion. rdcu.be/dfWJw
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3 Jul 2023
The idea is simple. The growing understanding of the significance of IDRs by researchers outside the IDP field has increased the importance of making high quality, unambiguous and understandable IDP data accessible to the wider community.
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3 Jul 2023
There has been a revolution in the complexity of the experiments characterising the structural properties of IDRs. This revolution has not been reflected by advances in the data standardisation of the field. Now is the time to put those foundational concepts in place.
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