Using whole-body cell-level imaging to improve disease understanding and therapy development.

Joined May 2022
3 Photos and videos
For decades, we've asked where therapeutics go in the body. Now we can ask which cells they reach. Our new SCP-Nano platform combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations. A new way to accelerate the development of safer and more precise therapies. Read our paper published at @NatureBiotech nature.com/articles/s41587-0…
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Deep Piction retweeted
Great to see @VirusesImmunity last paper highlighted at @NatRevImmunol. One of the strongest pieces of evidence yet for autoimmunity in #LongCOVID. Not proof that autoimmunity explains all neurological Long COVID, but it's getting harder to dismiss as one important mechanism.
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Amazing work by the entire @DeepPiction team! Proud to see this level of spatial biology pushing boundaries with wildDISCO — whole-body immunolabeling that delivers cellular-resolution 3D atlases while preserving full anatomical context in situ. 🧠🔬 Spatial biology has the power to show us real insights exactly where they matter most. At @neurosimplicity, we believe research teams should focus on biology and discovery, not data processing. That’s why we’ve built the Neurosimplicity Imaging Suite to automatically extract key insights and compare them against available or custom cohort atlases. More than that, though, the Imaging Suite is purposely built as a next-generation platform for seamless collaboration with terabyte-scale data. This is exactly the kind of breakthrough that deserves frictionless analysis and sharing. Congrats on the Nature Protocools paper! 🚀 #SpatialBiology #TissueClearing #Imaging #wildDISCO
Proud to be part of this team! 💪🧠🔬
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We developed wildDISCO, a whole-body immunolabeling method that makes entire mice transparent and maps cells in 3D using standard antibodies. We are now using this technology to develop powerful cell-level targeting therapeutics.
How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology. Check more at: nature.com/articles/s41596-0… #SpatialBiology #Imaging #TissueClearing
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We are working with Roger Luo who is now @LifeAtPurdue to visually map polyorganic sensory neurons. This work is absolutely powerhouse in terms of the technology!
How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology. Check more at: nature.com/articles/s41596-0… #SpatialBiology #Imaging #TissueClearing
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🚀 Meet Deep Piction at #BIOCAP26 in Berlin this week (June 9–11)! The biggest challenge in drug delivery isn't getting a payload into the body, it's knowing where it actually ends up. Our platform maps therapeutic biodistribution across entire organs at single-cell resolution, providing insights that conventional approaches miss. Stop by Booth 8B and chat with our Head of nanotechnology & drug delivery, @cerenkimna, about how we're accelerating the development of in vivo therapies for different diseases. #Biotech #DrugDevelopment #GeneTherapy #CellTherapy #PrecisionMedicine
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How do you map every cell in an entire mouse without slicing it into thousands of sections? Our recently published paper in @NatureProtocols describes wildDISCO: a whole-body immunolabeling approach that makes the mouse transparent and labels cells throughout the body using standard antibodies. The result? Cellular-resolution 3D atlases of entire organisms, preserving the anatomical context that is often lost in traditional histology. Check more at: nature.com/articles/s41596-0… #SpatialBiology #Imaging #TissueClearing
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Deep Piction retweeted
Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend @HarsharanBhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys. biorxiv.org/content/10.64898…
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We are excited to share our recent study describing DISCO-seq, a new technique that combines RNA-preserving tissue clearing with whole-organ 3D imaging to enable unbiased single-cell transcriptomics. Read here: biorxiv.org/content/10.64898…

Single-cell RNA-seq transformed biology, but we still sample <0.001% of an organism. 2D sections lose 3D context. What if we image the whole body first? We Introduce DISCO-seq🤩: full 3D imaging then scRNAseq👇🏻biorxiv.org/content/10.64898… by @HarsharanBhatia, Laurent Simons et al.
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From Whole Body to Single Cell. At DeepPiction.com we can see where disease begins and identify ways to make therapies safer & more effective. We’re excited to share our new paper at @Nature! Our goal is to advance drug discovery for #Cancer, #LongCovid & #Inflammation

May 22
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/4dD02sq
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If you missed the video for our recent @Nature study, check it out 👇🏼 Turn on the sound! We added some art to it 😊
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733
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