The Fallopian Tube’s Secret Bodyguards 🛡️ I am thrilled to share our lab’s latest study which flips the script on how we think about the origins of ovarian cancer. For a long time, ciliated cells in the fallopian tube were seen as "passive bystanders" in tumor development. Our research reveals they are actually active guardians of genomic integrity. We found that these cells use a STING-driven surveillance mechanism to act as a biological "cleanup crew," clearing away damaged cells before they can turn into high-grade serous carcinoma (HGSC). When these "gatekeepers" are lost, the door swings wide open for cancer to initiate. This discovery shifts our understanding of the epithelial microenvironment and points toward new strategies for early prevention. aacrjournals.org/cancerres/a… @UMich @UMRogelCancer @CR_AACR @UMichPath

Congratulations to Jose Colina, Analisa DiFeo, and colleagues on their simultaneous publication—Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium—presented earlier today at #AACR26. Read the article: brnw.ch/21x1Qiw @Difeolab

Excited to share the Ovarian Cancer Research Syndicate line-up for the fall. Please share. We have amazing trainees presenting and the latest from leaders in the field. @bitlerlabucd @DiFeoLab @WAGO_org @ocrahope @BasserBRCA @TheWistar @airdlab @OvCaAcademy @DNasioudis @achuthz

Watch our interview with Analisa DiFeo, PhD, recipient of the 2025 Molecular Cancer Therapeutics Award for Outstanding Journal Article, to learn more about her research: brnw.ch/21wUtYK @DiFeoLab @umichmedicine @UMichPath @UMRogelCancer

It takes a village, I can truly say I love my job b/c I enjoy the people I work with @ronny_drapkin @delapuente_lab @castro2355_mg @gouthamnarla @UMRogelCancer @UMich @umichmedicine @UMichResearch @umich @LyssiotisLab @uppals @DNagrathLab

Harini Ram, undergraduate @umichLSA student in the @DiFeoLab, was recently awarded the 2025 Astronaut Scholarship from the @AstroScholarFdn, an award presented to students pursuing a STEM field to conduct research upon completion of their degree. Ram, the only student from @UMich to receive the award, is currently working on ovarian cancer research where she is studying miR-181a and MYC-mediated metabolic reprogramming in the tumor microenvironments of high-grade serous carcinomas. Her goal is to obtain her medical degree and PhD in a Medical Scientist Training program after graduation. #GoBlue #UMichPath Read more👉 michmed.org/RBMPy

Congratulations to Analisa DiFeo, PhD, and colleagues, recipients of the 2025 Molecular Cancer Therapeutics Award for Outstanding Journal Article. Learn more and read the article: brnw.ch/21wTivI @DiFeoLab @umichmedicine @UMichPath @UMRogelCancer

Congratulations Grace this is a well-deserved recognition of your hard work, scientific curiosity, and dedication to advancing cancer research. We're especially grateful to the Rogel Cancer Center for their continued investment in young scientists—support like this makes transformative research possible.

Feeling incredibly honored and deeply grateful to MCT for this recognition, and to all my amazing collaborators and co-authors who made this work possible. Congratulations to @DiFeoLab @umichmedicine @UMichPath @UMRogelCancer Learn more: brnw.ch/21wSfdk #AACR25

Congratulations to Analisa DiFeo, PhD, and colleagues, recipients of the 2025 Molecular Cancer Therapeutics Award for Outstanding Journal Article. Learn more: brnw.ch/21wSfdk #AACR25 @DiFeoLab @umichmedicine @UMichPath @UMRogelCancer @AACR

📢JOIN US LIVE Wednesday, April 9, 4 PM ET! We're co-hosting the @RNASociety RNA Collaborative Seminar Series with @UR_Med, featuring talks by Ph.D. candidate Grace McIntyre @DiFeoLab and @NilsWalterLab Senior Scientist @AdrienChauvier Zoom registration 👉us02web.zoom.us/webinar/regi…

Learn about the collaborative research happening in our lab to discover innovative RNA therapies for cancer.@UMRogelCancer @UMichPath

Congratulations Dr. Puleo ⁦@Noah_Puleo⁩ on successfully defending your PhD thesis. It was a pleasure mentoring you and seeing you evolve into an accomplished scientist and leader. Good luck on your next endeavor and I’m excited to see your many future successes.

Read our latest review on miR-181a, the oncogenic miRNA shaping tumor pathways and immune defenses. Uncover its potential to revolutionize precision medicine and RNA therapeutics! #RNAtherapeutics #noncodingRNAs tandfonline.com/doi/full/10.…

What a crew!! Happy Holidays from our team to yours!! @TeitelJessica @Noah_Puleo @amandapearrl

Small but mighty…excited for the future of miRNA in cancer and therapeutics!@umichrna thanks for highlighting my thoughts on the impact of this years Nobel Price!

PP2A emerges as a master regulator of the integrated stress response pathway, controlling TFE3, ATF4, & CHOP. Paving the way for PP2A-modulating drugs that selectively target cancer cells. Big potential for safer cancer treatments! nature.com/articles/s41418-0…

What a group of passionate, intelligent, and dedicated scientists!! #cancerbio @UMRogelCancer @umichmedicine

What an amazing Ovarian Cancer conference @RivkinCenter @AACR It is remarkable to see so many passionate scientists, physicians, and patient advocates coming together to work on finding a cure!