Happy to see this collaboration led by
@DumonceauxTim , with key contributions from
@TPellegrinetti during his time in the lab! 🎉
What makes this study especially exciting for me is that Tim and I first started discussing the hypothesis that ‘Candidatus Phytoplasma pruni’ lacked cpn60 (GroEL) back in 2016, while we were developing diagnostic tools based on this molecular marker. At the time, it was an intriguing observation, but the available genomes were too fragmented to provide a definitive answer.
Almost a decade later, thanks to new high-quality genome assemblies, comparative genomics, and extensive work, we now have compelling evidence that this phytoplasma lineage has indeed lost a functional GroE chaperonin system. This work provides fascinating insights into genome reduction, gene loss, and the evolutionary trajectories of phytoplasmas.
Congratulations to everyone involved! 👏🧬🌱
Open access manuscript in Microbial Genomics:
doi.org/10.1099/mgen.0.00174…