Our latest work on #phaseseparation! We know changing environments can alter protein phase separation in cells, but can genetic changes do so as well? We addressed this by analyzing the phase-separation of a synthetic system in the yeast KO library 👇 biorxiv.org/content/10.1101/…
Our new AI model CLSS that can co-embed protein sequences and structures is out at tinyurl.com/4wsvswut.
We use a CLIP-like lean contrastive model (~35M million trained parameters!) and have super-exciting results.
With Guy Yanai, Gaby Axel, @LiamLongo, and Nir Ben-Tal.
Years ago, we discovered that missense mutations in homomeric proteins can induce their supramolecular assembly, as in the 📽️👇 - Question: how are such aberrant assemblies of *folded* proteins handled in a eukaryotic cell? The answer here: biorxiv.org/content/10.1101/… 🧵 below
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators.
nature.com/articles/s41586-0…
March 19 deadline - don't forget to submit your abstract for $500/$1000 Travel Awards and Open Talks for our 39th Annual Symposium in San Francisco. Abstract submission fee is $15 for student members and $30 for all other students. The Protein Society is committed to awarding 100 travel awards to support students world-wide.
Foldseek-Multimer is a strategy for complex-to-complex protein structure alignment to quickly perform large-scale structural comparisons between complexes. @thesteinegger @ElevyLabnature.com/articles/s41592-0…
I am thrilled to say that our work is now online @CellCellPress ! I've analysed protein structures for quite some time, but @Robb_Mallik, who co-led this work, took these analyses to yet another level - 🧵👇
sciencedirect.com/science/ar…
Super cool simulations from the HarmonLab model a synthetic system from our lab that exhibits phase-boundaries measurable in cells. The simulations relate PS behavior to protein shape/conformation. Now I want to design conformation-regulated PS! biorxiv.org/content/10.1101/…
CellWalk is now available on the @AppStore for iPhone and iPad! The future of biology education is interactive and immersive.
apps.apple.com/ca/app/cellwa…
Accelerated computing is revolutionizing protein structure prediction, starting with lightning-fast multiple sequence alignments.
Read more about #AlphaFold and #MMseqs2GPU:
developer.nvidia.com/blog/bo…
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Our latest work on #phaseseparation! We know changing environments can alter protein phase separation in cells, but can genetic changes do so as well? We addressed this by analyzing the phase-separation of a synthetic system in the yeast KO library 👇 biorxiv.org/content/10.1101/…
Anecdotally, we identified an ORF of unknown function (YLR402W) as an influencer of phase separation and cell size - it could be called AIS1 for "Altered Intracellular phase Separation 1"