Cardio-Immunologist, Macrophages. Associate Prof, Univ of Toronto. UHN. Research Director Peter Munk Cardiac Center. Loretta Rogers Chair
Joined October 2013
- Tweets 2,382
- Following 581
- Followers 1,448
- Likes 2,797
37 Photos and videos
Pinned Tweet
7 May 2024
Our latest study, led by @Homaira_H. Hard to study #macrophages (MFs) in early human heart development (no tissue). Homaira integrated human ES-derived-MFs into beating cardiac microtissues & improvedđź«€function. rdcu.be/dHbj0. #cardioimmunology #regeneration.
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Jun 12
Senescence is often viewed as a uniform pathological state @lexi_rindone found SnCs form distinct "senotypes" that organize-specialized tissue niches regulating fibrosis, immune signaling, vascular remodeling biorxiv.org/content/10.64898… #Senescence #Fibrosis #Aging @sennetresearch
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Jun 10
Chronic air pollution exposure (even moderate) and more advanced coronary artery disease
pubs.rsna.org/doi/10.1148/ra…
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placental NAD gates onset of labor!
science.org/doi/10.1126/scie…
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Excited to share another review article. This paper focuses on the spatial localization of cardiac macrophages in uninjured and infarcted hearts. Please give it a read!
Also thanks to my supervisor @SarahADick for all the support.
doi.org/10.1016/j.cjca.2026.…
#macrophages #heart
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Jun 11
A damage accumulation model identifies distinct aging regimes across species
nature.com/articles/s43587-0…
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Jun 11
We're learning a lot about cellular senescence, how to track it, and its role in aging and disease. Cover and commentary @CellCellPress
cell.com/cell/fulltext/S0092…
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Jun 11
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS:
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…
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Jun 10
We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis.
nature.com/articles/s41586-0…
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Jun 9
Excited to share our new paper, accepted by Cardiovascular Research! To build on our previous paper on CD8 T cells in anthracycline toxicity we show distinct cellular roles for STING in T cell recruitment and fibrosis! academic.oup.com/cardiovascr… @CVR_TomaszGuzik @PilarAlcaidePhD
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Jun 10
Persistent and transient senescent cells contribute to brain-barrier development: @CellCellPress cell.com/cell/fulltext/S0092…
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Prolonged Inflammation Associates With Greater Infarct Size and Poor Outcome After ST-Segment Elevation Myocardial Infarction | JACC: Basic to Translational Science jacc.org/doi/10.1016/j.jacbt…
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Jun 5
Happy to share new study from the lab!
We developed Effero-seq to explore dynamic changes in single-macrophage gene expression and function following efferocytosis in the TME. Proud of @RoiBalaban and @OriMoskowitz for leading the study published in @SciImmunology
Jun 5
We are thrilled to share the newest publication from our lab! In this work, @RoiBalaban & @OriMoskowitz investigated the effect of #efferocytosis on #macrophage state and function in the #TME.
science.org/doi/10.1126/scii…
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Jun 6
The next frontier for prevention of heart and vascular disease isn't targeting lipids. It's about blocking inflammation. These are some of the ongoing clinical trials @NatureMedicine
nature.com/articles/d41591-0…
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Congratulations to @jeremiahfaith1, @grinsa01, and @sinaiimmunology on a big milestone in microbiome therapeutics: nature.com/articles/s41591-0… (1/2)
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100s labs ordered the wrong "p16" antibody.
They wanted to study p16-INK4a, but bought p16-ARC antibodies.
312 papers got it wrong.
Now the literature is polluted with false mechanistic pathways.
Validate your reagents. But also read the datasheet and use your brain.
Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a completely wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins 🧵
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Very excited to share our latest paper, published as a Research Letter in Circulation. We show a significant role for adaptive immunity in arrhythmogenic right ventricular cardiomyopathy.
ahajournals.org/doi/10.1161/…
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Jun 3
Sepsis is a balancing act: too little immunity fails to control infection, too much causes tissue damage. Our @ScienceMagazine paper reveals one mechanism behind this tradeoff.
science.org/doi/10.1126/scie…
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Jun 1
Using smartphone facial video clips with AI to passively and accurately get heart rate, across all skin pigmentation groups @nature
"This is the first demonstration that smartphones
can be used to monitor both HR and daily RHR passively during normal personal phone use in the real world."
nature.com/articles/s41586-0…
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May 31
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
nejm.org/doi/full/10.1056/NE…
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May 29
1/ Can we predict who will develop #cardiotoxicity from #cancer therapy before starting treatment?
We built a deep learning model that does that, using #CMR images alone. A thread on how 👇
📝link: authors.elsevier.com/a/1nArx…
#cardioonc @dineshpmcc1 @CmcintoshAi @ICOSociety
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