Assistant Professor @Stanford University Genetics. Synthetic Biologist // Real Human 🧬 🔬 💻 🏳️🌈 🏊🏾♂️
Joined January 2022
- Tweets 1,092
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- Followers 2,523
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May 14
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
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Jun 7
In SF briefly next week and wanna try something new.
I'm reserving time to meet new folks working on AIxBio: new therapeutic and measurement modalities, harness design, boring-but-critical problems beyond discovery, etc. DM me.
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Jun 4
A holy grail for our lab has been tracking myeloid cells in human tumors in the same way that we track T and B cells with TCR/BCR.
@vincentzliu and @CalebLareau solved it!
We developed Mitotrek using scATAC-seq mitochondrial DNA to do exactly this. Using Mitotrek, we find that new myeloid cells clones constantly infiltrate the tumor via circulating monocytes — and that their macrophage or dendritic cell fate is epigenetically programmed before tumor entry.
@10xGenomics @parkerici @CancerResearch @TheMarkFdn
cell.com/cancer-cell/fulltex…
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🌟 In a month, the Hegde Laboratory opens at @EinsteinMed. While this marks the culmination of more than a decade of research with exceptional mentorship, it also represents an exciting new chapter in our collective quest for the development of next-gen myeloid drugs. 🧵👇
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Kyle G Daniels retweeted
🚨3rd paper in our PI3Ka public neoantigen trilogy is out in @PNASNews! We show that HLA micropolymorphisms govern whether a neoantigen is visible to T cells by tuning neopeptide dynamics, not presentation or static structure. @MSKCancerCenter @parkerici
pnas.org/doi/10.1073/pnas.26…
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Jun 2
🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!👇
biorxiv.org/content/10.64898…
Jun 2
The preprint from my work @MoKhalilLab and @DunlopLab at BU is out on bioRxiv! As new tools come online to engineer multicellularity, we asked: how does sticking cells together into larger groups affect their fitness and function?
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Kyle G Daniels retweeted
Jun 3
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
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Jun 1
Outstanding new work by my colleague @Barnabas_Daru at Stanford University!Biogeographic processes underlying global patterns of plant diversity | Science science.org/doi/10.1126/scie…
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May 25
Genuinely envious of all the cool people doing cool projects here 🥳
May 24
Excited to announce that the @stanleyqilab & Dr. Wing Wong are partnering with the Biohub network to reprogram the body's defenders!
Honored to be part of this incredible cohort of teams pushing the boundaries of synthetic immunology. biohub.org/blog/immune-cell-…
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Kyle G Daniels retweeted
May 22
Thrilled to share our new paper out today in @NatureCancer:
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases.
A single dose of radiotherapy makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues.
nature.com/articles/s43018-0…
🧵 (1/14)
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May 21
Had a fantastic retreat and inspiring scientific discussions with our collaborators! So great to exchange ideas with the Ryann Fame lab and Sarah Bowling lab @Stanford. Looking forward to where our science takes us! #ScienceTwitter @LabFame @SarahBowling15
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Kyle G Daniels retweeted
Charissa Chau’s glioblastoma battle inspired her husband, Antoine d’Haussy, to raise $50K for GBM research—split between two labs, including the lab of @MichaelLimMD 🧠. A micro-effort showing small acts add up ⚡ Read the full story here: stan.md/gbmresearch-gift.
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Kyle G Daniels retweeted
Protein/enzyme engineering has a severe bottleneck — and it's not in AI modeling or compute time.
It's in actually building and testing protein variants.
Proud to introduce our latest work, MIDAS: a way to go from primers to protein assays in mammalian cells in one day. 🧵
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Kyle G Daniels retweeted
When linear models and deep learning give the same results, orders of magnitude more training data are needed nature.com/articles/s41592-0… ;
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Kyle G Daniels retweeted
May 16
Our latest study of the scavenger receptor CD163, led by @RichardZhou_. This follows our previous study of how CD163 uses its remarkable molecular architecture to bind haptoglobin-haemoglobin. We now show how its flexible arms allow haemoglobin binding and ligand promiscuity.
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Kyle G Daniels retweeted
DNA-guided CRISPR–Cas12 for cellular RNA targeting go.nature.com/49SP29d
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Kyle G Daniels retweeted
May 14
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
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Kyle G Daniels retweeted
Officially Dr. Sanjeev Herr, MD, MS!
Looking forward to a productive post-doc year and then reapplying and matching into neurosurgery next cycle!
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May 16
HONORED to receive the Kuwait Prize! A testament to the achievements and hard work of Khalil lab members past and present. It’s an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian 🙏
tinyurl.com/2jvrjszb
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May 15
High-throughput biochemistry enables quantitative characterization of proteins at scale -- but now synthesis of isolated, sequence-validated libraries has become a bottleneck. Check out @MicahOlivas1 & @patrickalmhjell's new preprint to solve this! @Stanford_ChEMH @czbiohub
May 11
Many experiments in biology happen one protein at a time, which means synthesizing DNA one gene at a time. This is fine for tens of genes. For thousands, the cost is unsustainable.
Introducing uSort-M: a method to isolate and sequence-verify thousands of genes at low cost
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Kyle G Daniels retweeted
May 14
Want the precision and control of RNA devices but not sure how to engineer your lenti to deliver them?
🚨new pre-print from @kaseyslove🚨
hint: syntax matters! 👇
Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits biorxiv.org/content/10.64898… #biorxiv_synbio
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