New preprint on bioRvix! We show how cortical sensory-modality identity is instructed by a combinatorial cell-adhesion and activity codes using #snRNAseq #spatialtranscriptomics #functional imaging. Led by @T_Guillamon & @lpuche_1 from @GLB_Lab. Congrats @GuilleLBendito @NeuroAlc

The NIH has additional opportunities available for exceptional senior-level candidates to lead Institutes and the Intramural Research Program within the NIH. These leadership roles provide overall executive direction and scientific leadership for the Institutes mission and vision and the Intramural Research Program and serve as a principal advisor to the NIH Director concerning matters related to their institute's research oversight. For more information, including specific qualification requirements and application procedures, visit: lnkd.in/eaekg5_U

@E11BIO is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵

Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702

2. @AdamMarblestone & @Andrew_C_Payne on how to map the mammalian brain’s connectome to solve fundamental problems in neuroscience, psychology, and AI robustness: ifp.org/mapping-the-brain-fo…

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in @ScienceAdvances Collaborators Berenice Benayoun, @BBParis1984 Kaitlin Casaletto @YokoyamaLabUCSF @SimonsFdn @NIH science.org/doi/10.1126/scia…

We will be hosting 3rd Full Circle Symposium for Native Biologists hosted at UCSF in April 2025! We aim to build community and provide opportunities for Native biologists. If you are a Native biologist who is interested fill this out to stay up to date: forms.gle/AN7nfkhdB3Fvdkkm7

Check out our work, where we discover how receptor GPCR senses pH! We develop foundational GPCR DMS tech dev structural bio that will have impact across historically intractable receptor systems! Led by brilliant PhD student @matthewkhoward and Nick Hoppe w/ @AashishManglik!

Our latest work in collaboration with the Bourhy Lab (Pasteur Inst.) in which we use scRNA-seq to characterize host-rabies molecular interactions across diverse human brain cell types. Recommended if you're interested in "system virology" or glial biology: tinyurl.com/3a7e9vwp

We are looking for a postdoctoral fellow to join us to study somatosensation development and function! I’m committed to the training and success of my trainees. Please help me spread the words!

4/14 We used human hippocampus from patients who had brain surgery for refractory epilepsy. We sliced samples and transduced them on day 0, and our custom tissue-prep pipeline allowed for our high-density MEA recording experiments after up to 8 days in tissue culture.

Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: nature.com/articles/s41593-0… @JohnPAndrews_MD @UCSFstemcell