Medical Oncologist | Clinical Investigator | Cancer Drug Developer | Associate Chair IRB | HPB Cancers | Phase 1 | MSKCC

Joined June 2023
Photos and videos
James J. Harding, MD retweeted
New findings presented at #ASCO26 suggest a new approach could help slow the growth of intermediate-stage liver cancer. An international phase 3 clinical trial led by MSK's Dr. Ghassan K. Abou-Alfa (@GABOUALFA) found that adding dual immunotherapy to TACE significantly increased progression-free survival for people with hepatocellular carcinoma (HCC). “By combining dual immunotherapy with TACE, we give patients a better chance of living longer while preserving a healthy, working liver.” Learn more: bit.ly/4x7vt7o
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#ASCO2026 @MSKCancerCenter Advanced Fellow @OrlaFitz10 2 fantastic posters, #HER2 #RAS #BTC! Advanced Fellow Aruj Dhyani #YIA #ADC #BTC Assistant Attending @rohit_thum #MTAP #NET #BTC #PDAC. Glad to mentor, but grateful for what you teach me too!
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James J. Harding, MD retweeted
Proud to see 18 MSK staff recognized as 2026 Conquer Cancer Grants & Awards recipients ahead of #ASCO26. Congratulations to this outstanding group helping advance the future of cancer research and care. 👏
We're thrilled to officially announce the 2026 class of Conquer Cancer Grants and Awards recipients! 🔬 These grants empower the next generation of physician-scientists to turn innovative ideas into clinical breakthroughs. Congratulations to the new class—see you in Chicago for #ASCO26! Full list of recipients here: bit.ly/4x0qpBF #ResearchConquersCancer #ConquerCancer @ASCO
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Looking forward to joining faculty of this year #cancer #phase1 #HPB @myESMO @MSKCancerCenter
⏳ Still time to join #ESMOTATAsia26 Be part of ESMO Targeted Anticancer Therapies Asia 2026, a key Asia Pacific forum for cancer drug development. 👉 Register by 3 June and save: ow.ly/Xn2u50Z4Gzc #ESMOMeetings
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James J. Harding, MD retweeted
⚠️ New MSK research presented at #AACR26: A drug given “breakthrough designation” by @US_FDA may offer the best new option in many years for people facing #pancreaticcancer. #Daraxonrasib targets mutations in the RAS gene, which helps control cell growth — these mutations send signals that fuel cancer cells. #KRAS is the most common of these mutations and drives over 90% of pancreatic cancer, which is projected to be the second most deadly cancer in the U.S. by 2030. MSK gastrointestinal medical oncologist @EileenMOReilly led a phase 1/2 clinical trial of daraxonsarib as part of a larger multidisease trial led by thoracic medical oncologist Dr. @KCArbourMD. In Dr. O’Reilly’s trial, the patients with pancreatic cancer had not yet received any form of treatment. “This drug is potentially going to be a landmark shift in how we treat pancreatic cancer,” says Dr. O'Reilly. “The ability to target RAS mutations that drive so much of pancreatic cancer is huge and has been missing from our treatments.” Learn more about this research: bit.ly/4trr1xK @AACR
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James J. Harding, MD retweeted
Great to present phase 1b data for DLL3 ADC ZL-1310 (zoci) in platinum-refractory neuroendocrine carcinomas at #AACR26. Phase 2 is ongoing and we are excited to develop this drug further for these difficult to treat populations. @ZaiLab_Global @MSKCancerCenter @MSK_DeptOfMed
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James J. Harding, MD retweeted
🔥off the press: EMERALD-3 Phase III trial positive. 👉Significant PFS benefit for STRIDE/Lenva TACE, trend of OS benefit 👉Trend for PFS benefit for STRIDE TACE 🧐Looking forward to see more details @myESMO @EASLedu @ILCAnews
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Thank you @GABOUALFA, @MSK_DeptOfMed for many years of mentorship/support in #HPB cancers. Amazing to win this @theNCI #R01 award. @EileenMOReilly , @YJanjigianMD @DSolit @OlcaBasturk @MskccCMO @MSKBiostats @MSKCancerCenter
Congratulations @HardingJJMD on your #R01. @MSKCancerCenter @MSK_DeptOfMed and all colleagues are happy for you!
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James J. Harding, MD retweeted
Congratulations @HardingJJMD on your #R01. @MSKCancerCenter @MSK_DeptOfMed and all colleagues are happy for you!
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James J. Harding, MD retweeted
It was a great honor and delight for @MSKCancerCenter @MSK_DeptOfMed @GABOUALFA and @HardingJJMD to join this superb teaching effort. Thanks @oncodaily for the opportunity
𝗛𝗼𝘄 𝗜 𝗧𝗿𝗲𝗮𝘁 𝗚𝗮𝗹𝗹𝗯𝗹𝗮𝗱𝗱𝗲𝗿 𝗮𝗻𝗱 𝗕𝗶𝗹𝗲 𝗗𝘂𝗰𝘁 𝗖𝗮𝗻𝗰𝗲𝗿 𝗶𝗻 𝟮𝟬𝟮𝟲 | 𝗢𝗻𝗰𝗼𝗗𝗮𝗶𝗹𝘆 𝗩𝗶𝗿𝘁𝘂𝗮𝗹 𝗦𝘂𝗺𝗺𝗶𝘁 The Gallbladder and Bile Duct Cancer Summit 2026, organized by OncoDaily, brought together international experts to examine evolving clinical strategies and innovation shaping the management of gallbladder and biliary tract cancers. During this session, Ghassan Abou-Alfa (@GABOUALFA), James J Harding (@HardingJJMD), Vinay Kumar Kapoor (@vkkapoor_india) and Thatcher Heumann (@HeumannThatcher) shared expert perspectives on contemporary systemic therapy for biliary tract cancers, the fundamental “Ten Commandments” guiding gallbladder cancer management, practical approaches to treating gallbladder cancer in clinical practice, and emerging HER2- and RAS-targeted therapies shaping the future of hepatobiliary oncology.💡 Join the live conversation: x.com/i/broadcasts/1nKOLELlk… #OncologySummit #GlobalOncology #CancerTreatment #OncoDaily #Oncology #Cancer #Health #Medicine #GallbladderCancer
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Great Ride for #Liver #bileduct #cancer! Thank Chris Crane and Matt McMillan for joining The LIVE Riders! @Cycle4Survival @MSK_DeptOfMed @MSKCancerCenter.
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James J. Harding, MD retweeted
Fantastic panel discussion on the future of #HCC therapy with @MarkYarchoan @DrElkhoueiry @HardingJJMD @DJPinato @JosephFranses #richardfinn The near future is a “plateau” while we await the next breakthrough @AnjanaPillaiMD @docamitgs @laurakulik1 #livertwitter
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James J. Harding, MD retweeted
Radiologists play a critical role in assessing systemic therapy response in liver cancers; this requires a comprehensive approach beyond size changes to support personalized management. @VChernyakMD @taehyung_rad @DrRichardDo @MishalLala @HardingJJMD bit.ly/45YVCcB
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James J. Harding, MD retweeted
20 Dec 2025
NRG1 fusion-positive solid tumors: clinical detection, genomic landscape, and real-world data in #PDAC @JNCI_Now doi.org/10.1093/jnci/djaf361 🔎NRG1 pts at Memorial Sloan Kettering 👉76,531 pts > 48 NRG1 cases 👉Young pts, enriched in RAS WT PDAC 👉RNA testing is key @myESMO
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James J. Harding, MD retweeted
Final Results from a First-in-Human Phase I Study of the Dual IDH 1/2 Inhibitor, LY3410738, in Solid Tumors Harboring IDH1 or IDH2 Mutations @CCR_AACR doi.org/10.1158/1078-0432.CC… 🔎119 pts mono, 19 pts with CISGEM 👉ORR 5.2% & 11.1% 👉LY3410738 CISGEM in BTC: ORR 42%, mPFS 8mo 🧐Could be interesting in BTC @myESMO @EASLedu
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Fantastic international conference @GABOUALFA. Always great learning opportunities. @MSKCancerCenter @MSK_DeptOfMed
Congrats @AUB_Lebanon Kassem Salam & thanks for @MSKCancerCenter @MSK_DeptOfMed Monthly GI Oncology International Fellowship Videolink Conference, superb #cholangiocarcinoma review. Thanks @HardingJJMD for your #her2 valuable input . See you all 1/14/16 with @ILSONDavid
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James J. Harding, MD retweeted
22 Nov 2025
For adults with metastatic HER2-positive #BiliaryTractCancer, zanidatamab led to longer overall survival and reduced pain, supporting its role as a precision therapy option. ja.ma/3LX1GuL
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Agree, reflex HER2 IHC for all patients with biliary tract cancer. @MSKCancerCenter @MSK_DeptOfMed
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