Excited to share our new @TheLancet Perspective with @EricTopol . For decades, the thymus was considered largely irrelevant after childhood. Emerging evidence now suggests this “forgotten organ” may play an important role throughout life.

Thank you, @EricTopol! It has been a true pleasure collaborating on this perspective. Amazing to see how rapidly our understanding of this long-overlooked organ is evolving, and how AI and imaging may help make immune system health measurable at scale.

Grateful for the collaborations and support from: @TheLancet @scrippsresearch @MassGenBrigham @MGBResearchNews @Harvard @harvardmed @MaastrichtUMC

I wrote about this 6 weeks ago at Ground Truths when the 2 @Nature papers by @HugoAerts and colleagues came out. Today it's a "Health Alert"! wapo.st/4dmGMQU

📊 New key findings on the thymus: ☑️ Better thymic health ➡️ lower cancer & cardiovascular mortality ☑️ Linked to improved immunotherapy outcomes ☑️ Influenced by lifestyle factors like smoking & obesity 👨‍⚕️ @HugoAerts of @MassGenBrigham | @Nature 🔗 ascopost.com/news/march-2026…

The medical dogma has been that the adult thymus is involuted, fatty tissue, and not functional. Was that ever wrong! erictopol.substack.com/p/you…

Don't take the time to read about the new landmark studies that put our thymus gland at center stage for healthy aging erictopol.substack.com/p/you…

Loved this deep dive into our recent @Nature papers on thymic health. Insightful take and great breakdown of the key ideas. @EricTopol, thank you for taking the time to explore it in detail!

Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness @Nature @Simon_Bernatz @aim_harvard @nbirkbak @AarhusUni @HugoAerts nature.com/articles/s41586-0… nature.com/articles/s41586-0… nature.com/articles/d41586-0…

Beyond all of this, in a 2nd @Nature paper by the same team thymus, health associated with improved response to cancer immunotherapy @HugoAerts @simonbernatz and colleagues nature.com/articles/s41586-0…

Using AI on CT data from 30,000 people, we found that the health of the thymus varies strongly between people – and is linked to longevity, disease risk, and response to immunotherapy.

Did you know your face can reveal your biological age? Researchers at @MassGenBrigham developed FaceAge, an #AI algorithm that predicts biological age and survival outcomes for patients with cancer using a single photo. Patients with cancer appeared five years older than their actual age, and higher FaceAge predictions were linked to worse survival outcomes. Read more: massgeneralbrigham.org/en/ab… #AI #CancerResearch #HealthTech

Did you know your face can reveal your biological age? @MGBResearchNews has developed FaceAge, an #AI algorithm that predicts biological age survival outcomes for patients with cancer using a single photo. Patients with cancer appeared five years older than their actual age, and higher FaceAge predictions were linked to worse survival outcomes. Learn more: spklr.io/6019CPed #CancerResearch #HealthTech

Cross-Care is our new #LLM benchmark for measuring safety/bias in the #healthcare domain. We find misalignments between real biomedical facts, pretraining data, and LLM knowledge representation. Read more (arxiv.org/abs/2405.05506) and explore our website (crosscare.net/)

#TransferLearning self-supervision to characterize glioma doi.org/10.1148/ryai.230333 @HugoAerts @BrighamWomens @TYPoussaintMD #NeuroRad #ML #MachineLearning