Institute of Molecular Chemistry @CNRS UMR6302 @dijon @univbourgeurope
Joined February 2011
- Tweets 570
- Following 173
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64 Photos and videos
How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
Now in Nucleic Acids Res.: doi.org/10.1093/nar/gkaf1288
With @NJU1902 & @Polytechnique
@CNRS
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An ICMUB team has simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s
The TASQs story @ACSPublications: doi.org/10.1021/acs.accounts…
This new article @ChemEurJ: doi.org/10.1002/chem.2025030…
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A novel biotechnological application for DNA G-quadruplex #G4, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem.: pubs.acs.org/doi/10.1021/acs…
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The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
Now in ACS Bio & Med Chem Au: pubs.acs.org/doi/10.1021/acs…
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An interview of D. Monchaud, @CNRS researcher @icmub now published @PourlaScience to discuss about the results of Simon Elsässer and @PKnipscheer recently published in Science
👉science.org/doi/10.1126/scie…
👉pourlascience.fr/sd/genetiqu…
(sorry, in French only)
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A fruitful collaboration between @icmub (FR) and @iitgn (IN) supported by @EMBOFellows led to a novel strategy to fight against colorectal cancer, which relies on the pharmacomodulation of G-quadruplex #G4 found in miRNA.
Now published in @BMCBiology doi.org/10.1186/s12915-025-0…
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ICMUB is proud to have been associated with the very 1st meeting on DNA/RNA junctions IMAJ#1 organized by @dmonchaud.bsky.social and funded by @CNRSchimie (IRN). The meeting took place in Paris from 12 to 14 May, 2025 and was a real success! Great talks and enriching discussions!
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@icmub was associated to a consortium steered by @crctoncopole to decipher how G-quadruplex #G4 RNA can be leveraged for mitochondrial translation-targeted therapy to fight against cancers
Now in @NatureComms👍
@CNRSchimie @CNRS_Centre_Est @univbourgogne
doi.org/10.1038/s41467-025-5…
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In this new @J_A_C_S article, a collaboration between @ICMUB, @NanjingUnivers1, @Polytechnique and @univ_spn report on CoRP-seq, a technique that allows for mapping RNA G-quadruplex #G4 transcriptome-wide in a faster, cheaper and simpler manner!
👉 doi.org/10.1021/jacs.5c01172
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In this @STARProtocols article, J. Mitteaux & D. Monchaud from @icmub describe in a step-by-step manner how to fish RNA G-quadruplex #G4 out from human cells using commercially available TASQs, either BioCyTASQ (sigmaaldrich.com/FR/en/produ…) or MultiTASQ (sigmaaldrich.com/FR/en/produ…)
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Another beautiful collaboration between @ICMUB and @UTHealthHouston @McGovernMed which aims at deciphering the roles that G-quadruplex #G4 DNA and RNA play in human cells using chemical biology means.
@CNRS @CNRSchimie @univbourgogne
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A free-flowing and spirited discussion on @icmub research related to DNA structure oddities (G-quadruplex, #G4) that may have a profound impact on our daily lives (aging and age-related diseases).
Thanks to the CNRS (@CNRS @CNRSchimie @CNRS_Centre_Est) for this opportunity
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ICMUB retweeted
18 Oct 2024
#chimie ⚗️ #ResultatScientifique 📕 🔎 l Une nouvelle cible #thérapeutique prometteuse sur l’ADN de cellules #cancéreuses et des molécules capables de s'y attaquer de manière sélective.
🤝 @univbourgogne @CNRS_Centre_Est @dmonchaud
➡️inc.cnrs.fr/fr/cnrsinfo/cibl…
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‼️highlight alert‼️
Thanks @CNRSchimie for highlighting this @icmub work done in collaboration with @agranzhan @institut_curie @SebBritton1 @IpbsToulouse Nicolas Chéron @Chimie__ENS and Lukas Trantirek @CEITEC_Brno
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An @icmub contribution aiming at deciphering the roles that a peculiar DNA structure known as G-quadruplex #G4 plays in a neurodegenerative disease (XDP) published in @NAR_Open 👍👍👍
@CNRS @CNRSchimie @CNRS_Centre_Est @univbourgogne
19 Sep 2024
We are so proud to share our latest work on G-quadruplexes in the XDP neurodegenerative disorder, led by our postdoc @GiuliaNicolez, in collaboration with @ccxdp @dmonchaud and @GSchotta
👉academic.oup.com/nar/advance…
@SaraNRichter_ @DMM_Unipd @LMU_Muenchen @ICMUB @MassGenBrigham
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ICMUB retweeted
2 Aug 2024
Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions (David Monchaud and co-workers) @agranzhan @institut_curie @dmonchaud @icmub @CNRSchimie #openaccess onlinelibrary.wiley.com/doi/…
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An historical perspective on DNA interacting compounds used as anticancer agents, written by an @icmub @univbourgogne @CNRSchimie member in honour of Prof. Stephen Neidle @ucl @School_Pharmacy @ucllifesciences
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Targeting DNA junctions for fighting against cancers!
An @icmub work in collaboration with Paris, Toulouse and Brno (CZ). Congrats to all authors!
@univbourgogne @CNRSchimie
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