Joined November 2020
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Puck Knipscheer retweeted
Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.… Don’t miss this outstanding meeting!
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Puck Knipscheer retweeted
The Supervisory Board appoints Thijn Brummelkamp as a Member of the Executive Board/Scientific Director of the NKI as of Dec 1, 2024, succeeding Ton Schumacher who served as an ad interim scientific director following RenƩ Medema's departure in April 2024: bit.ly/4fg0ZGm
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Puck Knipscheer retweeted
Thrilled to share our new finding that the DUB USP37 suppresses rogue ubiquitylation and disassembly of stressed replisomes by TRAIP. Fantastic collaboration between Olga Kochenova in my lab and Giusi D’Alessandro in Steve Jackson’s lab! Read all about it: biorxiv.org/content/10.1101/…
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Are you interested in DNA replication, DNA repair or chromatin? Do you have a passion to find out how proteins function in these processes? Are you collaborative and ambitious? Check out these open positions in my lab (and @FMattiroli lab): hubrecht.eu/about-us/working…

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Only one more week to apply! Come and join us at our amazing institute @_Hubrecht in the charming and centrally located city of Utrecht.
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Puck Knipscheer retweeted
Are you interested in DNA replication, DNA repair or chromatin? Do you have a passion to find out how proteins function in these processes? Are you collaborative and ambitious? Check out these open positions in my lab (and @FMattiroli lab): hubrecht.eu/about-us/working…

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Puck Knipscheer retweeted
Afscheidsbijdrage van ⁦@Jorrit_Kelder⁩: ā€œUniversitair beleid vloeit niet voort uit de wensen en behoeften van wetenschappers, maar beantwoordt steeds vaker verzoeken uit Den Haag. (..) Laat onderzoekers het bepalen, die weten waarover ze het hebben.ā€œ mareonline.nl/opinie/den-haa…
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Puck Knipscheer retweeted
The Hubrecht Institute has openings for junior and senior group leaders. It's open to any discipline in life sciences. The Hubrecht is truly one of the best places in the world to start your lab, so apply! hubrecht.eu/job/tenure-track…

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If you are interested in an update on G-quadruplex (G4) structure resolution @QuadruplexPape1, check out our review in the special issue of DNA repair on genome maintenance @DNArepair. Many thanks to Koichi Sato @KoichiS0813 who did most of the work. authors.elsevier.com/sd/arti…

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Ever wondered whether there is a function for colocalization of #Gquadruplex (G4) structures and #Rloops? In this pre-print we show how DNA:RNA hybrid formation promotes G4 suppression to maintain genome integrity (biorxiv.org/content/10.1101/…). 1/7

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This mechanism suppresses G4 structures and thereby prevents G4-replisome collisions to maintain genome integrity. While here the RNA is supplied in trans, part of this mechanism could also remove G-loops during transcription. Why are incisions and re-synthesis required? 6/7
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We envision that the replacement of the displaced strand opposite the G4 ensures genome fidelity because this strand is vulnerable to damage and deamination. Alternatively, it could regulate the epigenetic state at promotors. More to be learnt in future studies! 7/7
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Puck Knipscheer retweeted
Only one week left to apply for a junior/senior group leader position at our institute! The vacancy and information on how to apply can be found here: hubrecht.eu/job/group-leader… šŸ“ø: Jeroen Korving
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Puck Knipscheer retweeted
Great vibes at the first ever joint retreat of the @duxin_lab and @PKnipscheer lab! Amazing talks and discussions 🐸🧬 #xenopus #dnarepair
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Puck Knipscheer retweeted
NWO, our Dutch national science funder, has signed the new ā€œAgreement on Reforming Research Assessmentā€ (ARRA). This is bad news. See our letter: Europe should maintain measurable criteria for assessing scientists. @RecogRewards @ScienceEurope @NWONieuws 1/n
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Puck Knipscheer retweeted
Come experience what it is like to be a scientist by doing experiments yourself, learning about the work of researchers and by visiting the pop-up laboratory! @UMCUtrecht @_Westerdijk_ @Wetenschap_NL #WvdW22
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