Oncogenic function and transcriptional dynamics of MYCN in liver tumorigenesis | PNAS

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. It is often diagnosed at advanced stages and characterized by high r...

A cohort study of sustainable cultivation methods in mandarin orange orchards across Japan

Variability in environmental conditions and farming practices often leads to discrepancies between experimental results and outcomes in farmers’ field …

The First Star-by-star $N$-body/Hydrodynamics Simulation of Our Galaxy Coupling with a Surrogate...

Systematic discovery and engineering of synthetic immune receptors in plants

Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase...

Predictive grid coding in the medial entorhinal cortex

The entorhinal cortex represents allocentric spatial geometry and egocentric speed and heading information required for spatial navigation. However, it remains unclear whether it contributes to the...

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Levodopa stimulates an enzyme in the brain to break down amyloid-β and restore cognition in mice.

An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases

Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type and connect specific cell types to diseases. Using a 5′ single-cell RNA sequencing approach, we defined transcr...