Protein Engineering and Evolution. Views my own.
Joined August 2013
- Tweets 1,697
- Following 1,030
- Followers 2,037
- Likes 5,379
108 Photos and videos
Colin Jackson retweeted
Our review on AI for protein engineering is out now, about this too-fast-moving field full of hype and overclaim, yet one that is having a real impact on the world and can be described in a coherent manner without histrionics
science.org/eprint/666XRGRCV…
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Colin Jackson retweeted
Our new ICLR paper on leveraging “soft decomposability” of design spaces (eg protein sequence) wrt a target property (eg enzymatic activity) in order to more efficiently search through the design space. Active site vs. scaffold, for eg. @jamesbowden_ joint with @svlevine
Mar 21
I'm excited to share our ICLR paper on how leveraging decomposability can enable more efficient scientific design, with @jlistgarten and @svlevine. We were motivated by protein design in particular. Check out the blog post: james-bowden.github.io/dado/.
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Colin Jackson retweeted
Our new paper on leveraging ML to characterize the fitness landscape of two proteins binding through evolution, wrt geometry, epistasis, etc. The super hard work of Hanlun Jiang, Stephan Allenspach and @jamesbowden_ on our end. science.org/doi/10.1126/scie…
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Colin Jackson retweeted
New, full length ProteinGuide manuscript, now spanning interpolative, extrapolative and multi-property (extending Pareto optimality) settings; comparisons to fine-tuning; and beating 7 rounds of directed evolution with just one round of ProteinGuide.
arxiv.org/abs/2505.04823
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Delighted to share our publication in @NatureComms on the computational design of generalist carbene transferases with tailored, stereodivergent selectivity! Great collab with Sagar Khare! Kudos to Zhuofan, Mary, and Xinkun and all other coauthors!
nature.com/articles/s41467-0…
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Colin Jackson retweeted
New Preprint!! We show that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! biorxiv.org/content/10.64898…
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Jan 20
biorxiv.org/content/10.6... most proteins are multi domain but our understanding of how architectures evolve is limited - we mapped 40K chitinases and show a stepwise grammar of domain gain/loss and localisation changes that predicts ecological strategy and physiological function
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Jan 20
Protein design mostly targets single domains; but bio builds function by recombining domains into larger multi domain proteins. Understanding the evolutionary rules of domain assembly will be important if we want to design the level of functionality seen in many native proteins
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Colin Jackson retweeted
Jan 11
"We propose that the p-value be demoted from its threshold screening role and instead, treated continuously."
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Excited to share our latest work: Continuous Serial Electron Diffraction for High Quality Protein Structures biorxiv.org/content/10.1101/…
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Colin Jackson retweeted
16 Sep 2025
Deeply honored to be part of the 2025 @schmidtsciences Polymath cohort! 🥳
16 Sep 2025
Congratulations to Nozomi Ando, @CornellChem professor! She's been named a @schmidtsciences Polymath, part of a global cohort of 8 scientists & engineers with “remarkable track records, promising futures and a desire to expand their research portfolios."
as.cornell.edu/news/nozomi-a…
ALT Person posing in a lab
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Colin Jackson retweeted
18 Aug 2025
‘Protein evolution as a complex system’ – A new Comment discusses protein evolution in terms of complex systems theory and machine learning approaches to model the dynamics of protein evolution
nature.com/articles/s41589-0…
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Colin Jackson retweeted
22 Jul 2025
Really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with a little help from #directedevolution to do #chemistry not known in nature (and not easily done by humans).
22 Jul 2025
#Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes by Jennifer L. Kennemur, Yueming Long, Catherine J. Ko, Anuvab Das, and @francesarnold at @CaltechCCE in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Colin Jackson retweeted
22 Jul 2025
Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses & enables rational phage design. Fun collab with Charlie Mo, exceptional work by Jackie Chen!
📝 Cell Host & Microbe: doi.org/10.1016/j.chom.2025.…
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Applications for this position close tomorrow. Don't miss out!
🌟We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids🌟
Join us at @ourANU with amazing collaborators and great working conditions!
Apply: tiny.cc/corry. Us: karri.anu.edu.au
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Colin Jackson retweeted
13 Jul 2025
Stepping into Substack, starting with (baby) thoughts on LLMs & Scientists. Inspired by great work coming out of ICML, new endeavors like @FutureHouseSF, and self reflections on my use of LLMs. stephaniewankowicz.substack.…
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Colin Jackson retweeted
2 Jul 2025
Our recent paper looking at history of flagellar motility now online in final form @ISMEJournal
We looked at 10,000 species to map the diversity and history of the bacterial #flagellar motor across the tree of life.
@UNSWBABS
@UNSWScience
academic.oup.com/ismej/artic…
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