Husband, Dad, Professor/Director. Chemical Biology, Drug Discovery, TPD, PROTACs, Molecular Glues, ADCs, Proteomics, & AI/ML. We do 💻🧪🧬 🐁 Views are my own.
Joined February 2011
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9 Photos and videos
Jin Wang 王津 retweeted
The @JinWangLab, H Lin et al developed a new analytical tool to optimize the potency and selectivity of drugs. #drugDesign @NatureComms @GENbio genengnews.com/topics/drug-d…
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18 Mar 2025
Congratulations to Xiangyu Deng and Yang Gao at @RiceUniversity for their outstanding work unraveling the complexities of RNA editing! Biochemical profiling and structural basis of ADAR1-mediated RNA editing: Molecular Cell cell.com/molecular-cell/full…
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18 Mar 2025
Interestingly, using the biochemical assays developed in this publication, we tested ZYS-1 (which I noted last week is not a genuine ADAR1 inhibitor) and confirmed it fails to inhibit ADAR1 even at concentrations as high as 1 mM.
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18 Mar 2025
Congrats again to Yang Gao and the entire team for their pioneering research! Stay tuned for more of our work on this exciting target.
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9 Mar 2025
Excited to share our new preprint on @biorxivpreprint , where we challenge the claim that ZYS-1 is a potent ADAR1 inhibitor, as reported by Wang et al. in @NatureCancer. Re: Concerns Regarding the Validation of ZYS-1 as a Bona Fide ADAR1 Inhibitor biorxiv.org/content/10.1101/…
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9 Mar 2025
Our results revealed that ZYS-1 does not inhibit ADAR1 activity at concentrations up to 1 mM, challenging previous conclusions based solely on binding data.
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9 Mar 2025
This underscores the need for target-specific assay validation in drug discovery. Join the conversation and read our full preprint for a detailed discussion. #ADAR1 #DrugDiscovery #RNAEditing #CancerResearch #AssayValidation
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Jin Wang 王津 retweeted
20 Feb 2025
We just releasd our new docking tool: ProteniX-Dock ! Welcome everyone to try out~
GNU GPL3 so allows commercial use, and has a nice Python interface and CLI😁
Let's dive into it! 🧵
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Jin Wang 王津 retweeted
19 Feb 2025
The NIH funds 4,400 active projects totaling $2.5 billion in Texas, much of it in Houston.
These cuts violate the law, hurt people, and undermine the very system of scientific research & groundbreaking advancements that we are so proud happen in #TX07.
houstonchronicle.com/politic…
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Jin Wang 王津 retweeted
3 Feb 2025
Today, we at OpenAI launched Deep Researcher and I wanted to share a deeply personal story about how amazing this tool is and how it will change the world. Trigger warning, related to cancer....1/9
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Jin Wang 王津 retweeted
11 Nov 2024
Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmind/a… 1/2
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Jin Wang 王津 retweeted
28 Oct 2024
This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov/
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Jin Wang 王津 retweeted
16 Oct 2024
Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. @CellCellPress @MDAndersonNews cell.com/cell/abstract/S0092…
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Jin Wang 王津 retweeted
22 Sep 2024
Recruiting faculty to the Dept of Molecular and Cellular Biology at Baylor College of Medicine in Houston, TX! Recruiting broadly in cancer and cell biology. Submit by October 1, 2024, for full review. #cellbio @BCMhouston
bcm.edu/departments/molecula…
jobs.sciencecareers.org/job/…
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