Twitter for the Jon Brown Lab, located in the division of cardiovascular medicine at Vanderbilt University Medical Center. @VUMChealth 🧬 āš“ļø

Joined April 2020
2 Photos and videos
Jon Brown Lab retweeted
Happy Thanksgiving šŸ¦ƒšŸšŸ½ from this rockstar ⁦@VUMCMedicineRes⁩ ⁦@VUMC_Medicine⁩ team! Grateful to get to work alongside these amazing doctors. #WomenInMedicine Thx to all #healthcareworkers serving today!
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Jon Brown Lab retweeted
Congrats to Ronan Bracken graduate student in @JonBrownLab. Advancing to PhD candidacy in @VandyBiochem. #donewithquals!!! šŸ™ŒšŸ§¬šŸ§¬šŸ§¬
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Jon Brown Lab retweeted
Join us in welcoming our new #TechnicalEditor @CircRes Dr. Amanda Doran MD PhD from the Division of Cardiology @VUMC_heart. Her research focuses on the role of innate immunity and #inflammation resolution in #atherosclerosis. Congratulations! @AmandaDoranLab
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Jon Brown Lab retweeted
Big congrats to outstanding colleague & "Cardio-Immunologist" extraordinaire! & fellow PRB3 "neighbor" (well...until a few months ago)! @VUMChealth @VUMC_heart @AmandaDoranLab @JonathanBrownMD @JonBrownLab @JaneFreedmanMD @CircRes @AHA_Research @annetkiraboc1 @nhpetunia
Join us in welcoming our new #TechnicalEditor @CircRes Dr. Amanda Doran MD PhD from the Division of Cardiology @VUMC_heart. Her research focuses on the role of innate immunity and #inflammation resolution in #atherosclerosis. Congratulations! @AmandaDoranLab
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Jon Brown Lab retweeted
Excited to have Dr. Mac Linton present at @VUMChealth CV Research Series. Terrific colleague, scientist & even better hogfish cook & host! @JaneFreedmanMD @KathrynMooreLab @merrymanlab @alan_daugherty @JoshuaBeckmanMD @VAgrawalMDPhD
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Jon Brown Lab retweeted
The findings of a study in Nature demonstrate the potential of in vivo base editing as a possible treatment for Hutchinson–Gilford progeria syndrome and other genetic diseases by directly correcting their root cause. go.nature.com/38ktlQ1
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Jon Brown Lab retweeted
News & Views: No cure exists for the lethal premature-ageing condition Hutchinson–Gilford progeria. A gene-editing tool offers a way to treat the condition in mice, according to a Nature paper. Could this approach lead to an effective therapy? go.nature.com/3oom0EJ

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Jon Brown Lab retweeted
In vivo base editing shows promise in treating the genetic accelerated-aging disorder Hutchinson–Gilford progeria syndrome in mice - find out more in our latest highlight of research by @jonbrownlabVUMC @davidrliu @LiuGroup et al. go.nature.com/3igjwpJ
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Jon Brown Lab retweeted
Congratulations to @SarnoffCardio & @BrighamFellows alumnus/current @VUMChealth cardiologist Dr. John Brown. Really nice story & demonstrating power of teamwork. Can studying progeria provide insights into CV aging? @JonBrownLabVUMC @saptarsi_haldar @tmmichelangelo @Progeria
So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team @davidrliu @NIHDirector @LukeKoblan & Mike Erdos at NIH and my @VUMCResearch team @lindsaymdavison & Sean Doherty rdcu.be/cc90j
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Jon Brown Lab retweeted
7 Jan 2021
Great science marches on. A rare incurable disease—progeria—tackled by #CRISPR genome editing with striking results in mouse model nature.com/articles/s41586-0… @nature @davidrliu @NIHDirector @LukeKoblan @JonBrownLabVUMC David's ā˜…šŸ§µšŸ‘‡ x.com/davidrliu/status/13468…
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4…
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Jon Brown Lab retweeted
Full text here: rdcu.be/cc90j
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Jon Brown Lab retweeted
So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team @davidrliu @NIHDirector @LukeKoblan & Mike Erdos at NIH and my @VUMCResearch team @lindsaymdavison & Sean Doherty rdcu.be/cc90j

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Jon Brown Lab retweeted
Here is a really great article about our progeria work that mentions the early days where we only had DNA editing data from only a single LMNA c.1824 C>T mouse– @davidrliu, @JonBrownLabVUMC, and @NIHDirector may remember fondly! Check it out here: statnews.com/2021/01/06/cris…

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Jon Brown Lab retweeted
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4…
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Jon Brown Lab retweeted
I am incredibly thankful to have worked with such an amazing team led by @davidrliu, @JonBrownLabVUMC, and @NIHDirector with amazing contributions from Leslie Gordon at the PRF (@progeria) and all of our co-authors (especially my co-first author Mike Erdos)
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Light at the end of the tunnel! So thankful that #frontlineworkers and #HealthcareHeros are able to get the vaccine.
Got Covid vaccine shot 1 of 2 today! Feels Historic. #CovidVaccine #COVID19 @VUMChealth @VUMC_heart
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