The findings of a study in Nature demonstrate the potential of in vivo base editing as a possible treatment for HutchinsonāGilford progeria syndrome and other genetic diseases by directly correcting their root cause. go.nature.com/38ktlQ1
News & Views: No cure exists for the lethal premature-ageing condition HutchinsonāGilford progeria. A gene-editing tool offers a way to treat the condition in mice, according to a Nature paper. Could this approach lead to an effective therapy? go.nature.com/3oom0EJ
In vivo base editing shows promise in treating the genetic accelerated-aging disorder HutchinsonāGilford progeria syndrome in mice - find out more in our latest highlight of research by @jonbrownlabVUMC
@davidrliu@LiuGroup et al. go.nature.com/3igjwpJ
Research from the @JonBrownLabVUMC and collaborators have rescued mice afflicted with progeriaāaccelerated agingāwhich could lead to a cure for Hutchinson-Gilford progeria syndrome in humans.
news.vumc.org/2021/01/06/genā¦
Congratulations to @SarnoffCardio & @BrighamFellows alumnus/current @VUMChealth cardiologist Dr. John Brown. Really nice story & demonstrating power of teamwork. Can studying progeria provide insights into CV aging? @JonBrownLabVUMC @saptarsi_haldar @tmmichelangelo @Progeria
So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team @davidrliu @NIHDirector @LukeKoblan & Mike Erdos at NIH and my @VUMCResearch team @lindsaymdavison & Sean Doherty
rdcu.be/cc90j
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative Cā¢G-to-Tā¢A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4ā¦
So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team @davidrliu @NIHDirector @LukeKoblan & Mike Erdos at NIH and my @VUMCResearch team @lindsaymdavison & Sean Doherty
rdcu.be/cc90j
Here is a really great article about our progeria work that mentions the early days where we only had DNA editing data from only a single LMNA c.1824 C>T mouseā @davidrliu, @JonBrownLabVUMC, and @NIHDirector may remember fondly! Check it out here: statnews.com/2021/01/06/crisā¦
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative Cā¢G-to-Tā¢A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4ā¦
I am incredibly thankful to have worked with such an amazing team led by @davidrliu, @JonBrownLabVUMC, and @NIHDirector with amazing contributions from Leslie Gordon at the PRF (@progeria) and all of our co-authors (especially my co-first author Mike Erdos)