Cancer Metastasis | Cell Motility | Bioengineering @ JHU
Joined October 2019
- Tweets 200
- Following 273
- Followers 842
- Likes 1,147
59 Photos and videos
Konstantopoulos Lab retweeted
Jun 12
Two recent new publications from our laboratory, led by the amazing Jacob Odell and @ElpersMaggie, respectively, shed new insights into the role of nuclear #lamins and nuclear #mechanobiology in two different contexts.
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Konstantopoulos Lab retweeted
May 27
Congrats to @nicoleleejw (and other @ConfinementLab co-authors) on her main story coming out this month in @CellReports! Check out this thread if you’re interested in what Nicole discovered on the role #MechanicalMemory plays in facilitating cell migration in #confinement
9 Sep 2025
#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: biorxiv.org/content/10.1101/…
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May 11
So proud of our lab alumnus, @KaustavBera11 (PhD ’22), on joining @PurdueChemE as an Assistant Professor! Excited to see him launch his lab and continue advancing the frontiers of mechanobiology, biomaterials and tissue engineering. Wishing him every success in this new chapter!
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Congratulations to our PhD student @NitishSriv24401 on winning first place for poster presentation at the @INBT_JHU 19th Nano-Bio Symposium! He presented work on how our microfluidic devices can be used to predict GBM patient survival and advance precision medicine approaches.
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Konstantopoulos Lab retweeted
Our researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors. The strategy extended survival in preclinical models of glioblastoma and was led by @DoctorQMd and published in @NatureComms. Read the findings.
newsnetwork.mayoclinic.org/d…
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Pleased to share our collaborative work with the Kontrogianni group, now out in Advanced Science @AdvPortfolio. Led by Matthew & @Anindya_SenJHU , we show how delivery of PH domains suppress PI3K/Akt signaling and breast cancer metastasis. Read more:
advanced.onlinelibrary.wiley… [1/4]
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Furthermore, Kalirin and PLCγ1 PH-domains also suppress PI3K/Akt Activity, cell migration, and dissemination. [3/4]
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Finally, we identified the “p85 Inhibitory And Metastasis Suppressor” (PIMS) Motif within a subfamily of PH-Domains with anti-metastatic Potential. [4/4]
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Proud of our brilliant PhD student @nath_sanjiban2 for receiving the @HopkinsEngineer Teaching Assistant Excellence Award. Sanjiban served as TA for the graduate-level Transport Phenomena course. He is an excellent teacher and amazing researcher. Stay tuned for what’s next!
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1/4 Excited to share that 3 of my doctoral students have successfully defended their theses! Congratulations to @Anindya_SenJHU, @YQinling and @alice_amitrano on this major milestone. They are outstanding researchers and people. Looking forward to seeing all they accomplish next.
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3/4 Proud of Dr. @YQinling for her work on the function of membrane transporters in cell migration. Qinling, our cell biology expert, has first-author papers in Science Advances and Cell Reports, and work in journals such as NatComm and PNAS. Looking forward to her future success
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4/4 Proud of Dr. @alice_amitrano for her work on how mechanochemical cues control cell behavior. Alice has first-author papers in Science Advances, Cell Reports, and COCB, with another in review, plus work in journals such as Nano Letters, and NatMaterials. Exciting work ahead!
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Huge congratulations to our brilliant PhD student @BhawanaAg12 for winning the WSE @HopkinsEngineer Excellence in Research Trainee Award and being selected as 1 of only 7 presenters (out of 186 abstracts) at the @JohnsHopkins DOM/WSE Research Retreat. Incredible achievement! 🔬👏
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Feb 12
Pleased to share our work on how hypoxia restores acidosis-induced inhibition of cancer cell dissemination- now out in Cell Reports! Led by Se Jong Lee, @alice_amitrano , @YQinling & @debanikch. Many thanks to our lab members and our collaborators!
cell.com/cell-reports/fullte…
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Feb 12
💡Hypoxia restores motility under acidosis by upregulating NHE1/ILK signaling and glycolytic metabolism.
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Feb 12
💡Chronic adaptation to acidosis is not universal and relies on the cancer cell ability to restrain reactive oxygen species via fatty acid oxidation.
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28 Oct 2025
The Konstantopoulos Lab is heading to #AIChE2025 in Boston to share our latest discoveries in cell mechanobiology and microenvironmental cues. Stay tuned for exciting talks! #AIChEAnnual🧪
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