GPCRs in neural circuit function
Joined May 2019
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Kirill Martemyanov Lab retweeted
Feb 27
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 @scisignal study solved the structure of this extracellular protein that plays an essential role in vision.
In the retina, light is perceived by photoreceptor cells that transmit signals to neurons called bipolar cells, which in turn relay the signal to the retinal ganglion cells that form the optic nerve. The activation of bipolar cells by photoreceptor cells depends on the precise positioning of multiprotein complexes on the surfaces of both cell types.
Pikachurin is an extracellular matrix protein that bridges these complexes by making contacts with the membrane protein dystroglycan on the photoreceptor cell and the receptor GPR179 on the bipolar cell, thus ensuring that photoreceptor cells are properly aligned with the bipolar cells.
Learn more: scim.ag/41dTWIP
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29 Nov 2025
From the one and only Jacob Rowe. An Editorial Pick which highlights top papers at the greatest @jbiolchem ! Check it out- this is molecular engineering at its best.
29 Nov 2025
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
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21 Oct 2025
Awesome work!!!
21 Oct 2025
New in JBC press: "Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways."
Learn more:
jbc.org/article/S0021-9258(2…
#jbiolchem
ALT Figure 1. Cellular stability of pathogenic BTB domain mutations in KCTD1.
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23 Jul 2025
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
nature.com/articles/s41467-0…
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31 May 2025
Wow!!!
31 May 2025
Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxiv/…
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23 Apr 2025
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao.
nature.com/articles/s41467-0…
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Kirill Martemyanov Lab retweeted
21 Apr 2025
The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
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Kirill Martemyanov Lab retweeted
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20 Mar 2025
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward.
pnas.org/doi/epub/10.1073/pn…
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13 Jan 2025
A popular FDA-approved drug to treat hypertension, hydralazine works, at least in part, by modulating RGS proteins! Honored to be a part of a collaborative team led by @MegaMatthewsLab!
biorxiv.org/content/10.1101/…
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7 Jan 2025
Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of @GPCRHenry. #GPCR , #Elfn1, @jbiolchem
sciencedirect.com/science/ar…
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Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it.
biorxiv.org/content/10.1101/…
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18 Oct 2024
An amazing paper- a treat to read! Can't be more proud of former postdocs doing awesome science! Go Brian Muntean!
pnas.org/doi/10.1073/pnas.24…
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Kirill Martemyanov Lab retweeted
4 Oct 2024
As shown recently a single point mutation in G protein alpha subunit yields a stable complex without the use of stabilizing nanobodies!
nature.com/articles/s41467-0…
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28 Sep 2024
Spot on!
27 Sep 2024
A few postdocs asked me to read over their job applications. Here’s a few bits of advice: 🧵 /10
1. If any advice doesn’t ring true for you, discard it (including this!)
2. People on the search committee are keen to welcome a colleague, they aren’t looking to take you down
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20 Jun 2024
Soluble GPCRs! Check it out! Congrats @befcorreia !
nature.com/articles/s41586-0…
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4 May 2024
This is a must read masterclass in sensory circuit dissection and really cool behavioral adaptation!
2 May 2024
In a new study led by @mike_fitz23, we describe a pupillary contrast response in mice and humans, which senses temporal contrast to enhance spatial contrast in the retinal image and increase visual acuity. We decipher the underlying neural mechanisms. bit.ly/3w8ieIV
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8 Apr 2024
Frizzled receptors are so cool. Consolidated model of GPCR realm with scaffolding signalosome.
8 Apr 2024
Check out our new review in TiPS "Frizzleds act as dynamic pharmacological entities" written with the postdocs in the team: @GraetzLukas @PKozielewicz @MagdalenaScharf @JanVo12 and twitterless Julien Bous.
authors.elsevier.com/sd/arti…
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8 Apr 2024
This is an amazing progress! Breathtaking structure and a cool model!
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